Immunomodulation by behavioural conditioning

Kusnecov, Alex; King, Maurice G.; Husband, Alan J.

doi:10.1016/0301-0511(89)90109-9

Cited by 20 publications

(7 citation statements)

References 55 publications

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“…In 1975, R. Ader and N. Cohen advanced PNI with their demonstration of classic conditioning of immune function, and coined the term "psychoneuroimmunology" [5]. H. Besedovsky and co-workers demonstrated that classic hormones and newly described cytokines are involved in functionally relevant cross-talk between the brain and the immune system [6].…”

Section: Historical Review Of Pni Developmentmentioning

confidence: 98%

Psychoneuroimmunology - Psyche and Autoimmunity

Ziemssen

2012

CPD

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Psychoneuroimmunology is a relatively young field of research that investigates interactions between central nervous and immune system. The brain modulates the immune system by the endocrine and autonomic nervous system. Vice versa, the immune system modulates brain activity including sleep and body temperature. Based on a close functional and anatomical link, the immune and nervous systems act in a highly reciprocal manner. From fever to stress, the influence of one system on the other has evolved in an intricate manner to help sense danger and to mount an appropriate adaptive response. Over recent decades, reasonable evidence has emerged that these brain-to-immune interactions are highly modulated by psychological factors which influence immunity and autoimmune disease. For several diseases, the relevance of psychoneuroimmunological findings has already been demonstrated.

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Section: Historical Review Of Pni Developmentmentioning

confidence: 98%

Psychoneuroimmunology - Psyche and Autoimmunity

Ziemssen

2012

CPD

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“…The central nervous system and the immunological processes are strictly and bidirectionally interconnected through neurotransmitters, hormones and cytokines, as demonstrated by psychoneuroimmunology (Kusnecov, King, &Husband, 1989). Recent studies have suggested that significant immune disturbances in the periphery may concomitantly influence the immune state of the brain, which in turn could modify the immune modulation peripheral pathways, contributing to the susceptibility of the subject to autoimmune disorders, particularly in genetically predisposed individuals (Theofilopoulos, Kono, &Baccala, 2017;Dantzer, 2018).…”

Section: Accepted Articlementioning

confidence: 99%

Psychological profile and unexpected pain in oral lichen planus: A case–control multicenter SIPMO study^a

et al. 2021

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Objectives:To analyze psychological profiles, pain and oral symptoms in patients with oral lichen planus (OLP).Materials and methods: 300 patients with keratotic OLP (K-OLP; reticular, papular, plaque-like subtypes), 300 patients with predominant non-keratotic OLP (nK-OLP; erythematosus atrophic, erosive, ulcerative, bullous subtypes) and 300 controls were recruited in 15 universities. The number of oral sites involved and oral symptoms were recorded. The Numeric Rating Scale

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“…Ader and Cohen (1975) provided one of the earliest demonstrations of conditioned immunomodulation by showing that a gustatory stimulus which has been paired with the immunosuppressive drug cyclophosphamide can acquire immunosuppressive properties in mice. Subsequent investigations have demonstrated that many immune functions are susceptible to Pavlovian conditioning, including both innate and adaptive responses (for reviews see Ader and Cohen, 2001;Kusnecov et al, 1989). Furthermore, conditioned immune alterations have been shown to modify disease progression in numerous models of clinical diseases, indicating that conditioned effects on the immune system are biologically significant (Ader and Cohen, 1982;Exton et al, 1998;Klosterhalfen and Klosterhalfen, 1983;Lysle et al, 1992b).…”

Section: Introductionmentioning

confidence: 99%

Neuroimmune mechanisms of opioid-mediated conditioned immunomodulation

Saurer¹,

Ijames²,

Carrigan³

et al. 2008

Brain, Behavior, and Immunity

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Morphine administration elicits pronounced effects on the immune system, including decreases in natural killer (NK) cell activity and lymphocyte mitogenic responsiveness. These immune alterations can become conditioned to environmental stimuli that predict morphine as a result of Pavlovian conditioning processes. Prior work in our laboratory has shown that acute morphine exposure produces dopamine-dependent reductions of NK cell activity that are mediated peripherally by neuropeptide Y Y1 receptors. The present study examined the involvement of dopamine D1 and neuropeptide Y Y1 receptors in the conditioned immunomodulatory effects of morphine. Rats received two conditioning sessions during which an injection of morphine was paired with a distinctive environment which served as the conditioned stimulus (CS). The results show that systemic administration of the D1 antagonist SCH-23390 prior to CS re-exposure prevented the conditioned suppression of splenic NK activity but did not alter conditioned decreases in mitogen-induced lymphocyte proliferation. Furthermore, bilateral microinjections of SCH-23390 directly into the nucleus accumbens shell fully blocked conditioned changes in NK activity. In a subsequent manipulation, subcutaneous injection of the Y1 receptor antagonist BIBP3226 prior to CS re-exposure was also shown to prevent conditioned effects on NK activity. Collectively, these findings provide evidence that the nucleus accumbens shell plays an important role in conditioned immunomodulation and further suggest that the conditioned and unconditioned immunomodulatory effects of opioids involve similar receptor mechanisms.

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Immunomodulation by behavioural conditioning

Cited by 20 publications

References 55 publications

Psychoneuroimmunology - Psyche and Autoimmunity

Psychoneuroimmunology - Psyche and Autoimmunity

Psychological profile and unexpected pain in oral lichen planus: A case–control multicenter SIPMO study^a

Neuroimmune mechanisms of opioid-mediated conditioned immunomodulation

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Immunomodulation by behavioural conditioning

Cited by 20 publications

References 55 publications

Psychoneuroimmunology - Psyche and Autoimmunity

Psychoneuroimmunology - Psyche and Autoimmunity

Psychological profile and unexpected pain in oral lichen planus: A case–control multicenter SIPMO studya

Neuroimmune mechanisms of opioid-mediated conditioned immunomodulation

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Psychological profile and unexpected pain in oral lichen planus: A case–control multicenter SIPMO study^a