Immunomodulation by dimethyl fumarate treatment improves mouse sciatic nerve regeneration

Bombeiro, André Luís; Pereira, Bruna Toledo Nunes; Bonfanti, Amanda Pires; Oliveira, Alexandre Leite Rodrigues de

doi:10.1016/j.brainresbull.2020.04.005

Cited by 18 publications

(12 citation statements)

References 36 publications

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“…Kapur and Marwaha (2011) showed that there was remarkable reduction in common signs of inflammation such as edema, erythema, and drastic increase of granulation and fibrin formation in patients with different types of wounds treated with EOW demonstrating an immunomodulatory effect [46]. In this regard, immunotherapy with the EOW could provide a survival advantage by reducing the clinical signs of infection and ameliorating the cardiac damage of Chagas disease by avoiding disease progression as seen with other immunotherapeutic agents against various pathologies, such as allergies, injury to the peripheral nervous system, Chagas disease, leishmaniosis, and other intracellular pathogens [47][48][49][50][51]. In this study, high parasitaemia, general physical condition (adynamia, arched back and piloerection), lethality and tissue parasite load considered to be typical clinical manifestations of ChD were ameliorated in mice treated with EOW.…”

Section: Discussionmentioning

confidence: 99%

Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected with Trypanosoma cruzi

et al. 2020

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Chagas disease is a major public health problem in Latin America. The mixed Th1/Th2 immune response is required against Trypanosoma cruzi. Electrolyzed oxidizing water (EOW) has been shown to have germicidal efficacy. The objective of this study was to evaluate the EOW effectiveness in T. cruzi-infected BALB/c mice clinically, immunologically, and histologically. The severity of the infection was assessed by parasitaemia, general health condition, mortality, mega syndromes, and histological lesions. IgG, TNF-alpha, IFN-gamma, and IL-1 beta levels were quantified. The EOW administration showed a beneficial effect on parasitaemia, general physical condition, and mortality. High levels of IgG1 at 50 days postinfection were observed. Prophylactic EOW treatment was able to induce a predominantly TH1 immune response based on an IgG2a levels increase at the late acute phase, and a 10-fold increase of IFN-gamma in whole acute phase. EOW was able to control the acute phase infection as effectively as benznidazole. Splenomegaly was caused by EOW treatment and lymphadenopathy was stimulated by T. cruzi infection in all groups. Severe tissue damage was not prevented by EOW treatments. Moderate efficacy may be due to immunomodulatory properties and not to a direct toxic effect on the parasite.

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Section: Discussionmentioning

confidence: 99%

Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected with Trypanosoma cruzi

et al. 2020

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“…In line with these pro-neuronal findings, DMF diminished the phosphorylated Tau (pTau) protein levels in vivo [131] and reduced the mitochondrial respiratory deficits [143] and membrane potential disruption [132] in microglia-medium-treated rodent neuronal cultures. Moreover, the levels of the neuronal differentiation markers neurofilament (NF) and growth associated protein 43 (GAP-43) increased following DMF treatment in a mouse sciatic nerve model [153]. Finally, even though DMF did not affect axonal refractoriness in hypoperfused mice, the evoked compound action potentials (CAPs) improved after treatment [123] and DMF reduced the intracellular Ca 2+ -levels in transgenic mice carrying the calcium-sensing fluorescent protein TN-XXL [105], again supporting a protective role of DMF towards neurons.…”

Section: Neuronsmentioning

confidence: 99%

Molecular Effects of FDA-Approved Multiple Sclerosis Drugs on Glial Cells and Neurons of the Central Nervous System

Kleijn

Martens

2020

IJMS

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Multiple sclerosis (MS) is characterized by peripheral and central inflammatory features, as well as demyelination and neurodegeneration. The available Food and Drug Administration (FDA)-approved drugs for MS have been designed to suppress the peripheral immune system. In addition, however, the effects of these drugs may be partially attributed to their influence on glial cells and neurons of the central nervous system (CNS). We here describe the molecular effects of the traditional and more recent FDA-approved MS drugs Fingolimod, Dimethyl Fumarate, Glatiramer Acetate, Interferon-β, Teriflunomide, Laquinimod, Natalizumab, Alemtuzumab and Ocrelizumab on microglia, astrocytes, neurons and oligodendrocytes. Furthermore, we point to a possible common molecular effect of these drugs, namely a key role for NFκB signaling, causing a switch from pro-inflammatory microglia and astrocytes to anti-inflammatory phenotypes of these CNS cell types that recently emerged as central players in MS pathogenesis. This notion argues for the need to further explore the molecular mechanisms underlying MS drug action.

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“…This may be due to the incomplete destruction of nerve fibers and regeneration of nerve fibers after RF-TC. Although neurons cannot be regenerated or their growth is slow, nerve fibers can be regenerated ( 31 ). Therefore, some patients may still relapse after RF-TC treatment.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of sympathetic radiofrequency thermocoagulation in the treatment of cold hypersensitivity

Liao

Xu²,

Xia³

et al. 2022

Front. Neurol.

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BackgroundCold hypersensitivity (CH) is a sensation of cold in the limbs and (or) body of a patient in an environment that is not considered cold by unaffected people, or a strong feeling of cold at a relatively low temperature. However, the currently available treatments are limited and often unsatisfactory. This study aimed to evaluate the clinical efficacy and safety of the sympathetic radiofrequency thermocoagulation (RF-TC) technique in patients with CH disorder.MethodsThe study is a retrospective analysis. A total of 71 were entered into the final analysis and all patients underwent computed tomography-guided thoracic (lumbar) sympathetic nerve RF-TC on an elective basis. The values of terminal temperature (T) and perfusion index (PI) of patients before and after treatment were recorded. Patients were followed up clinically at regular intervals and their Visual Analog Scale (VAS) and Pittsburgh Sleep Quality Index (PSQI) scores were recorded to detect postoperative complications and assess patient satisfaction with the treatment.ResultsAll patients completed the radiofrequency treatment. Compared with the preoperative period, VAS and PSQI scores were significantly lower at all postoperative time periods (P < 0.001). Patients had significantly higher postoperative terminal temperatures and perfusion indices on the right and left sides than before surgery (P < 0.001). The overall patient satisfaction score was 4 (3–5) at 3 years of postoperative follow-up. There were 20 recurrences (28.2%). The main postoperative complications were postoperative local pain and compensatory hyperhidrosis. No other adverse events or deaths were observed.ConclusionRF-TC for CH could be a feasible, effective, and safe treatment option to improve patients' symptoms of cold sensation. Yet, more researches are needed to verify this potentially efficient and standardized treatment.

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Immunomodulation by dimethyl fumarate treatment improves mouse sciatic nerve regeneration

Cited by 18 publications

References 36 publications

Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected with Trypanosoma cruzi

Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected with Trypanosoma cruzi

Molecular Effects of FDA-Approved Multiple Sclerosis Drugs on Glial Cells and Neurons of the Central Nervous System

Efficacy and safety of sympathetic radiofrequency thermocoagulation in the treatment of cold hypersensitivity

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