Immunomodulation by tramadol combined with acetaminophen or dexketoprofen: In vivo animal study

Filipczak-Bryniarska, Iwona; Nazimek, Katarzyna; Nowak, Bernadeta; Skalska, Paulina; Cieślik, Martyna; Fedor, Angelika; Gębicka, Magdalena; Kruk, Gabriela; Pełka-Zakielarz, Joanna; Kozlowski, Michael; Bryniarski, Krzysztof

doi:10.1016/j.intimp.2023.110985

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Additionally, another study has shown that IL-6 as a proinflammatory cytokine is produced immediately after injury; thus, a single dose of TRA was able to decrease its levels [ 28 ], but in our study, animals received repetitive doses of TRA for a long period of two months. After repetitive administration, it was demonstrated that the immune modulatory effect of TRA disappeared, and it is no longer considered as immunosuppressive as other opioids [ 29 ]. Our study has shown that long-term TRA administration to rats did not change even IL-10.…”

Section: Discussionmentioning

confidence: 99%

“…Considering eight weeks of continuous TRA administration in our study, the apparent decrease of IL-10 and IL-6 was probably due to TRA metabolites and not TRA itself. This suggests that chronic use of TRA might have a positive impact on the immune system, probably through suppressing the production of pro-inflammatory cytokines [ 28 , 29 , 31 ]. Furthermore, our findings have indicated that EXE significantly increased both IL-6 and IL-10 compared to the TRA group.…”

Section: Discussionmentioning

confidence: 99%

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High-Intensity Interval Training Ameliorates Tramadol-Induced Nephrotoxicity and Oxidative Stress in Experimental Rats

Sadat Hosseini,

Shirazpour,

Zangiabadizadeh

et al. 2024

Cureus

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Introduction: Tramadol (TRA) is an opioid analgesic widely prescribed for moderate-to-severe pain; however, its abuse and chronic use have been associated with kidney damage. Considering the protective role of exercise training in reducing organ damage, this study aimed to assess the influence of high-intensity interval training (HIIT) on a male rat's kidney following chronic TRA administration. Methods: In this experimental study, 30 male Wistar rats were assigned to the following groups: control (CON; animals received normal saline five days a week in the first month and three days a week in the second month), exercise (EXE; animals conducted HIIT training according to exercise protocol five days a week for two months), TRA (animals received TRA 50 mg/kg (i.p.) as described for the CON group), EXE-TRA (animals received TRA and conducted exercise protocol), and EXE-SL (animals received normal saline and conducted exercise protocol). Then, serum IL-6 and IL-10 levels, tissue malondialdehyde (MDA), total antioxidant capacity (TAC), glutathione peroxidase (GPx), superoxide dismutase (SOD), and levels of albumin, urea, and creatinine (CR), along with pathological changes in the kidney, were measured. A p-value of <0.05 was considered significant using GraphPad Prism v.9 (GraphPad Software, La Jolla, California, USA). Results: The inflammatory cytokines IL-6 and IL-10 were significantly increased in the EXE and EXE-TRA groups compared to the TRA group. Chronic administration of TRA in the TRA group decreased antioxidant indicators TAC, GPx, and SOD in kidney tissue while increasing oxidative stress MDA compared to the CON group (p<0.05). In contrast, the EXE-TRA group showed higher levels of TAC, GPx, and SOD, while MDA decreased compared to the TRA group. Additionally, serum levels of urea and CR were increased in the TRA group compared to the CON group, whereas these levels were decreased in the EXE-TRA group compared to the TRA group. The inflammatory effect of HIIT training, due to severe hyperemia and mild inflammatory cell infiltration, was seen in all EXE groups. Pathological findings confirmed TRA-induced kidney damage through moderate hyaline cast presence and severe apoptosis in the TRA group. Other findings were in line with the above results. Conclusion: These findings confirm the nephrotoxicity of chronic use of TRA through biochemical and oxidative markers and pathological outcomes. In addition, the result suggests that HIIT has the potential to mitigate the detrimental effects of TRA through reversing biochemical and oxidative markers, including TRA-induced apoptosis. Consequently, considering its restorative properties, HIIT could be explored as a prospective nephroprotective approach for long-term TRA treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High-Intensity Interval Training Ameliorates Tramadol-Induced Nephrotoxicity and Oxidative Stress in Experimental Rats

Sadat Hosseini,

Shirazpour,

Zangiabadizadeh

et al. 2024

Cureus

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Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo

Cieślik,

Strobel,

Bryniarski

et al. 2024

Biomedicine & Pharmacotherapy

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Opioid-free strategies for patient-controlled intravenous postoperative analgesia: a review of recent studies

Luo,

Rao,

Lei

et al. 2024

Front. Pharmacol.

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Postoperative pain management has consistently been a critical topic in the medical field, with patient-controlled intravenous analgesia (PCIA) being one of the most commonly utilized methods for postoperative analgesia. Currently, opioids remain the primary choice for PCIA in clinical practice. However, in recent years, an increasing number of studies have explored analgesic strategies aimed at reducing or eliminating the use of opioids in PCIA to mitigate the associated side effects and dependence. This article systematically reviews the progress of research on opioid-free analgesic strategies in PCIA through a comprehensive analysis of relevant literature.

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Immunomodulation by tramadol combined with acetaminophen or dexketoprofen: In vivo animal study

Cited by 3 publications

References 40 publications

High-Intensity Interval Training Ameliorates Tramadol-Induced Nephrotoxicity and Oxidative Stress in Experimental Rats

High-Intensity Interval Training Ameliorates Tramadol-Induced Nephrotoxicity and Oxidative Stress in Experimental Rats

Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo

Opioid-free strategies for patient-controlled intravenous postoperative analgesia: a review of recent studies

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