Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice

Shimada, Takashi; Cai, Yuanqing; Cheng, Long; Motonaga, Chie; Fukada, Kazutake; Kitamura, Yoshihisa; Wu, Jieshu

doi:10.1016/s1007-4376(09)60050-2

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Also at 12 th day post 2 nd vaccination in group (3), receiving 400mg pure β glucan /kg diet (high concentration). These results agree with previous findings (Schiffrin et al, 1997;Panigrahi et al, 2014;Diaz-Rosales et al, 2016) which recorded that probiotic including β glucan increases the activities of phagocytes, also with (Shimada et al, 2009) who reported that β glucan act on macrophages activity in a dose dependent manner. The activities of phagocyte may be explained as, the bacterial cell or bioactive peptide released during fermentation by lactic acid bacteria activate the immune response through a dynamic interaction with specific Toll-like receptors on the surface of macrophage (it was known that the phagocytosis by macrophages is Toll-like receptors dependent) this interaction between host cells and pathogens or their structural components may play a critical role in the early innate immune response.…”

Section: Discussionsupporting

confidence: 93%

The impact of β glucan on the Immune Response of Broiler Chickens Vaccinated with NDV and AI H9V Vaccines

lTawab

Elnaggar

El-Sissi³

2019

Benha Veterinary Medical Journal

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To evaluate the effects of β glucan on innate and adaptive immune responses of broilers vaccinated for routine vaccination with Newcastle disease virus (NDV) and Avian Influenza H9N2 (AIV) vaccines. A total of 180 chicks of one-day old Hubbard local breedThey were divided into three groups (sixty chicks for each group). The first group fed with normal broiler diet without any additives and served as control group, while the other two groups consumed diets contained (200mg , 400mg pure β glucan /kg diet respectively for 42 days of the experimental period. We noticed that, the administration of β glucan to broiler chickens early in life increased significantly (p<0.05) the nitric oxide levels, lysozyme activity, phagocytic activity, and phagocytic index , inaddition improved the oxidative state by decreasing malondialdehyde (MDA) and increasing glutathione (GSH) and. High concentration of β glucan improves immune response to NDV and AIV vaccines.

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Section: Discussionsupporting

confidence: 93%

The impact of β glucan on the Immune Response of Broiler Chickens Vaccinated with NDV and AI H9V Vaccines

lTawab

Elnaggar

El-Sissi³

2019

Benha Veterinary Medical Journal

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“…In addition to commonly used probiotic species, an animal experiment included in this review reported that heat-killed E. faecalis had an immunostimulatory effect in a murine model of oral candidiasis, which is beneficial for the treatment of oral candidiasis [36]. Heat-treated E. faecalis has been reported to have immunoenhancing effects that include increasing cell-mediated immunity, humoral immunity, monocyte/macrophage function, and natural killer cell activity in nonsensitized mice [43]. In 2012, an animal study aimed at the lysed E. faecalis in the murine model of allergic rhinitis suggested that E. faecalis has an immunoregulatory activity [44].…”

Section: Discussionmentioning

confidence: 99%

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

Zhou

Young

et al. 2019

BMC Oral Health

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Background To systematically review and assess the in vivo effectiveness and safety of probiotics for prophylaxis and treating oral candidiasis. Methods A literature search for studies published in English until August 1, 2018 was conducted in the following databases: PubMed, EMBASE, Cochrane Library, and Web of Science. Randomized controlled clinical trials and experimental mouse animal model studies comparing probiotics (at any dosage and in any form) with control groups (placebo, blank control or other agents) and reporting outcomes of the prophylactic and therapeutic effects were considered for inclusion. A descriptive study and, potentially, a meta-analysis were planned. Results Six randomized controlled clinical trials and 5 controlled experiments of mouse animal models were included in the systematic review. Four randomized controlled clinical trials comparing a probiotics group with a placebo/blank control group in 480 elderly and denture wearers were included in the meta-analysis. The overall combined odds ratio of the (random effects) meta-analysis was 0.24 (95% CI =0.09–0.63, P < 0.01). The overall combined odds ratio of the (fixed effects) sensitivity analysis was 0.39 (95% CI =0.25–0.60, P < 0.01) by excluding a study with the smallest sample size. These analyses showed that there was a statistically significant difference in the effect of probiotics compared with the control groups in elderly and denture wearers. The remaining 2 studies compared probiotics with other agents in a population aged 18–75 years and children aged 6–14 years respectively, and were analyzed descriptively. Meta-analysis and descriptive analyses indicated that probiotics were potentially effective in reducing morbidity, improving clinical symptoms and reducing oral Candida counts in oral candidiasis. The biases of the included studies were low or uncertain. The relatively common complaints reported were gastrointestinal discomfort and unpleasant taste, and no severe adverse events were reported. Conclusions Probiotics were superior to the placebo and blank control in preventing and treating oral candidiasis in the elderly and denture wearers. Although probiotics showed a favorable effect in treating oral candidiasis, more evidence is required to warrant their effectiveness when compared with conventional antifungal treatments. Moreover, data on the safety of probiotics are still insufficient, and further research is needed.

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“…The results of this study indicated that additives of microbial origin exerted a positive effect on growth performance and immune system function in Rainbow Trout. The biological response to Ef was previously evaluated by examining immunomodulation and immune-adjuvant effects in animal husbandry (Kotani et al 2008;Shimada et al 2009). Likewise, the immuno-nutritional aspects of cultured fish diets supplemented with MOS were evaluated by examining growth performance, immune stimulation, and disease resistance against pathogens (Sang et al 2009;Dimitroglou et al 2010;Sang and Fotedar 2010;Gu et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of Inactivated Enterococcus faecalis and Mannan Oligosaccharide and Their Combination on Growth, Immunity, and Disease Protection in Rainbow Trout

Rodriguez-Estrada¹,

Satoh²,

Haga³

et al. 2013

N American J Aquac

111

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We examined the effects of the following seven experimental diets that varied in the concentration of inactivated cells of Enterococcus faecalis (Ef) and mannan oligosaccharides (MOS), on Rainbow Trout Oncorhynchus mykiss: control (C) diet (no Ef and no MOS), diet E0.25% (2.5 g/kg Ef), diet E0.5% (5 g/kg Ef), diet M0.25% (2.5 g/kg MOS), diet M0.5% (5 g/kg MOS), diet EM0.25% (2.5 g/kg Ef + 2.5 g/kg MOS) and diet EM0.5% (5 g/kg Ef + 5 g/kg MOS). Rainbow Trout, initially weighing 36.27 ± 0.42 g (mean ± SD) were distributed into fourteen 60‐L glass tanks at a stocking density of 35 fish per tank. Each diet was hand‐fed to duplicate groups of fish twice daily for a 12‐week period. After the feeding test, an intraperitoneal injection challenge test of Aeromonas salmonicida was conducted over 14 d. Resulting data were submitted to a multivariate analysis of variance. Weight gain increased significantly (P < 0.05) in E0.25%, M0.25%, and EM0.5% experimental groups compared with the control. Specific growth rate was significantly higher (P < 0.05) in fish fed E0.25%, M0.25%, and EM0.5% diets compared with fish fed the C diet. Feed gain ratio and protein efficiency ratio were significantly improved (P < 0.05) in fish fed the EM0.5% diet compared with fish fed the C diet. Feed intake, protein efficiency ratio, protein retention, and the apparent digestibility coefficient recorded slight differences within experimental groups. Hematocrit value and phagocytic activity were significantly higher (P < 0.05) in fish fed E0.25%, E0.5%, M0.5%, EM0.25%, and EM0.5% diets compared with fish fed the C diet. Except for fish in the E0.25% group, fish in all other experimental groups showed a significantly higher (P < 0.05) mucus weight compared with those in the C group. After the challenge test, cumulative mortality and frequency of A. salmonicida were significantly decreased (P < 0.05) in all experimental groups compared with the C group. In conclusion, dosage and single or combined supplementation of Ef and MOS are factors that significantly affect fish performance.

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Immunomodulation effects of heat-treated Enterococcus faecalis FK-23(FK-23) in mice

Cited by 6 publications

References 19 publications

The impact of β glucan on the Immune Response of Broiler Chickens Vaccinated with NDV and AI H9V Vaccines

The impact of β glucan on the Immune Response of Broiler Chickens Vaccinated with NDV and AI H9V Vaccines

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

Effects of Inactivated Enterococcus faecalis and Mannan Oligosaccharide and Their Combination on Growth, Immunity, and Disease Protection in Rainbow Trout

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