Immunomodulation médiée par les agents antibactériens

Labro, M. T.

doi:10.1016/j.reaurg.2006.06.004

Cited by 2 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the advent of neomacrolides has made macrolides one of the effective antibiotics both in the hospital and in outpatients. Moreover, they are reputed to have non-antibacterial activities, in particular immunomodulatory and anti-inflammatory properties [7] [8]. Such properties are used in particular in the symptomatic treatment of pain caused by inflammatory cytokines released at the sites of infection [7] [8].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, they are reputed to have non-antibacterial activities, in particular immunomodulatory and anti-inflammatory properties [7] [8]. Such properties are used in particular in the symptomatic treatment of pain caused by inflammatory cytokines released at the sites of infection [7] [8]. However, in the fight against emergence of new resistant bacterial strains [2] [9] [10], Erythromycin A and neomacrolides have proved to be ineffective.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacochemical Aspects of the Evolution from Erythromycin to Neomacrolides, Ketolides and Neoketolides

Ouattara¹,

Songuigama²,

Jean-Paul³

2020

OJMC

View full text Add to dashboard Cite

Antibiotic macrolides are experiencing renewed interest in anti-infective therapy since the advent of ketolides. This therapeutic class was introduced in order to broaden the narrow antibacterial spectrum of macrolides and to cope with the emergence of germs resistant to Erythromycin A and its hemisynthetic derivatives or neomacrolides (Clarithromycin, Roxithromycin, Azithromycin, Dirithromycin). From a pharmacochemical point of view, ketolides were first of all obtained by operating chemical modulations on Erythromycin A to obtain the neomacrolides, then, by replacing the neutral sugar (L-cladinose) in C3 by a ketone function coupled with the creation of an oxazolidinone like heterocycle in C11 and C12 in place of the hydroxyls present in these positions (Telithromycin, Cethromycin, Solithromycin). These modulations have enabled the improvement of the chemical stability of ketolides in gastric acid medium and increase their affinity for the ribosomal target, hence the broadening of their spectrum of action towards Gram positive germs including strains resistant to other macrolides and to neomacrolides. Therefore, the objective of this systematic review is to report the various pharmacochemical aspects undertaken since 1952 in the macrolide series based on the structure of Erythromycin A. These aspects will focus on the pharmacomodulations that have led, year after year, to the optimization of stability, the improvement of the pharmacodynamic and pharmacokinetic profile and that have allowed the development of neomacrolides, ketolides and neoketolides, which are today essential in the management of severe bronchopulmonary infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacochemical Aspects of the Evolution from Erythromycin to Neomacrolides, Ketolides and Neoketolides

Ouattara¹,

Songuigama²,

Jean-Paul³

2020

OJMC

View full text Add to dashboard Cite

show abstract

Characterization of Algerian Honey from Tiaret Region and Immunoassay Study of Its Immunomodulatory Effect in BALB/c Mice

Mehdi¹,

Mebrek²,

Djebara³

et al. 2015

JFR

View full text Add to dashboard Cite

Honey is a food that possesses several antiseptic, antibacterial, anti-inflammatory and immunomodulatory properties. In this study, the immunomodulatory effect of honey was evaluated by Enzyme Linked Immunosorbent Assay (ELISA) using ovalbumin as an allergen model. To compare the honey quality, we conducted a range of physicochemical analyses on four different samples from the Tiaret region (Algeria) using the immunosuppressive or immunomodulatory effect in Balb/c mice. Our results show that the injection of 100 μL of honey before 6 hours, 6 hours after and at the same time as the injection of antigen (ovalbumin) causes a significant suppressive activity on production of the IgG isotype by Balb/c mice. This result corroborates this therapeutic virtue ascribed to honey which has resulted in a suppressive demonstration of honey on the humoral immune response. This opens an interesting perspective in the clinical area, as immunosuppressive agents play an important role in the transfer of various organs and immune system diseases.

show abstract

Immunomodulation médiée par les agents antibactériens

Cited by 2 publications

References 40 publications

Pharmacochemical Aspects of the Evolution from Erythromycin to Neomacrolides, Ketolides and Neoketolides

Pharmacochemical Aspects of the Evolution from Erythromycin to Neomacrolides, Ketolides and Neoketolides

Characterization of Algerian Honey from Tiaret Region and Immunoassay Study of Its Immunomodulatory Effect in BALB/c Mice

Contact Info

Product

Resources

About