Immunomodulatory activity in vitro and in vivo of polysaccharide from Potentilla anserina

Chen, Jiongran; Yang, Zujing; Hu, Ting‐Jun; Yan, Zuoting; Ting-xian, Niu; Wang, Ling; Cui, Dongan; Wang, Meng

doi:10.1016/j.fitote.2010.07.009

Cited by 115 publications

(77 citation statements)

References 28 publications

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“…Polysaccharide compounds in other plants (such as Solanum nigrum, Opilia celtidifolia, Potentilla anserina) have been reported to have immunomodulating activities [12][13][14]. In the present study, we confirmed these properties also in polysaccharide fraction C of Caltha palustris.…”

Section: Discussionsupporting

confidence: 86%

Experimental immunology Influence of polysaccharide fraction C isolated from Caltha palustris L. on T and B lymphocyte subsets in mice

Suszko¹,

Szczypka²,

Lis³

et al. 2012

cejoi

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Section: Discussionsupporting

confidence: 86%

Experimental immunology Influence of polysaccharide fraction C isolated from Caltha palustris L. on T and B lymphocyte subsets in mice

Suszko¹,

Szczypka²,

Lis³

et al. 2012

cejoi

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“…Phagocytic ability of the macrophages was measured by neutral red uptake (Chen et al, 2010;Kim et al, 2004). RAW 264.7 cells were cultured at 10 5 cells/well for 24 h in 96-well flat-bottom plates at 37 C in a 5% CO 2 chamber.…”

Section: Effect Of Bgp On Cell Phagocytic Activitymentioning

confidence: 99%

Immunomodulatory and immunorestorative activities ofβ-d-glucan-rich extract and polysaccharide fraction of mushroom,Pleurutus tuberregium

Nworu

Okoye²,

Esimone

et al. 2015

Pharmaceutical Biology

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Context: Some edible mushrooms are reputed to possess useful medicinal properties which are related to their ability to modulate the protective responses of the immune system. Objective: This study explored the immunomodulatory and immunorestorative properties of a hot aqueous extract (APTR) and of a b-D-glucan-enriched polysaccharide fraction (BGP) of a local oyster mushroom Pleurutus tuberregium (Fr.) Singer (Pleurotaceae). Materials and methods: Immunomodulatory activities were investigated by assessing specific and none-specific immune responses in immunocompetent and immunosuppressed mice; as well as in vitro in culture of RAW264.7 macrophages stimulated with BGP. Results: In a homologous prime-boost immunization schedule, oral supplementation with APTR (100, 200, or 400 mg/kg) and BGP (100 or 200 mg/kg) resulted in significantly higher titers of total IgG, IgG 1 , and IgG 2a by as much as 2-4-folds compared with the levels in untreated control mice. The mean hemagglutination (HA) titer in immunized mice that were treated with dexamethasone (DEX; 5 mg/kg) was significantly (p50.05) lower than the titer in groups that did not receive dexamethasone; however, short-term alternate day administration of APTR (200 mg/kg) to mice that had been immunosuppressed with 5 mg DEX/kg produced significant increases in secondary anti-SRBC antibody compared with the mean titer of mice immunized and treated with DEX alone. In in vitro studies, stimulation of RAW264.7 macrophages with BGP caused significant increases in iNO and TNF-a expression, and phagocytic functions of the cell. Conclusion: Taken together, the results of these studies showed that P. tuberregium imparts immunostimulatory and immunorestorative effects that could be explained, in part, by the actions of its b-D-glucan constituent(s) on macrophages.

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“…It is known that the combination of polysaccharides and Con A or LPS can regulate the activity of immune cells more significantly than Con A or LPS alone. In addition, LPS acts as a B cell mitogen, which directly stimulates mitosis of B cells and is a poly- clonal activator for B cells [44]. We elucidated that SP possesses a dual synergistic stimulatory effect on B lymphocyte or T lymphocyte proliferation combined with a T cell mitogenic response or B cell mitogenic response in bursa cell proliferation.…”

Section: Discussionmentioning

confidence: 97%

Inhibitory effect of Sargassum polysaccharide on oxidative stress induced by infectious bursa disease virus in chicken bursal lymphocytes

Zhang¹,

Hu²,

Liu³

et al. 2011

International Journal of Biological Macromolecules

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Immunomodulatory activity in vitro and in vivo of polysaccharide from Potentilla anserina

Cited by 115 publications

References 28 publications

Experimental immunology Influence of polysaccharide fraction C isolated from Caltha palustris L. on T and B lymphocyte subsets in mice

Experimental immunology Influence of polysaccharide fraction C isolated from Caltha palustris L. on T and B lymphocyte subsets in mice

Immunomodulatory and immunorestorative activities ofβ-d-glucan-rich extract and polysaccharide fraction of mushroom,Pleurutus tuberregium

Inhibitory effect of Sargassum polysaccharide on oxidative stress induced by infectious bursa disease virus in chicken bursal lymphocytes

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