Since endless decades, human beings rely on herbal medicines to cure various misfunction in the body. Plants are an essential source of phytochemicals like Alkaloids, Polyphenols, Terpenoids Glucosinolates & Glycosides which have numerous pharmacological values. Clinical studies show that these active constituents can function as immunomodulators. The review principally focuses on 14 Indian kitchen plants that are used as spices, namely Allium sativum, Cinnamomum tamala, Coriandrum sativum, Cuminum cyminum, Curcuma longa, Elettaria cardamomum, Mangifera indica, Murraya koenigii, Piper longum Linn, Piper nigrum, Syzygium aromaticum, Trachyspermum ammi, Trigonella foenum-graeceum and Zingiber officinale which enhances immune response in the body by both specific and non-specific mechanism. These botanical immunomodulators might open a new sight for novel drug development that is costeffective, with less adverse effects and toxicity.