Immunomodulatory activity of Anacardium occidentale L. in Laboratory animals

Abstract

Aim: To study the phytochemical analysis and immunomodulatory activity of ethyl acetate extract of nut of Anacardium occidentale Linn. Methods: A laboratory based experimental method was used to evaluate immunomodulatory activity by dividing animals into six different groups, comprising six animals in each group. The immunomodulatory activities were determined by using carbon clearance test, delayed type hypersensitivity (DTH) test and In vivo antibody (HA) titer response to SRBCs. Result: The response produced by oral administration of ethyl acetate extract of nut of A.occidentale showed a significant dose dependent effect by increase in Phagocytic activity, DTH response and augmentation of humoral immune response to sheep red blood cells. Conclusion: Ethyl acetate extract of nut of A. occidentale showed a significant immunostimulatory effect on both the humoral and cell-mediated immune systems in the Wistar albino rats.