2015
DOI: 10.1016/j.carbpol.2014.08.119
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Immunomodulatory activity of heparan sulfate mimetics from Escherichia coli K5 capsular polysaccharide in vitro

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Cited by 25 publications
(20 citation statements)
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“…Polysaccharides are relatively non-toxic and so have no significant side effects (Schepetkin & Quinn, 2006), therefore, they play pivotal roles in food, pharmacy and material industries (Jiao, Yu, Zhang, & Ewart, 2011). Plant polysaccharides are linked by glycosidic bonds and displayed wide biological activities, such as immunomodulation (Teng et al, 2015), anticancer (Suresh et al, 2013), antioxidation (Yang, Wang, Li, & Yu, 2015), antimicrobial (Krichen et al, 2015), and wound-healing (Lazareva et al, 2001). Anticancer activities of polysaccharides are particularly interesting to be intensively investigated.…”
Section: Introductionmentioning
confidence: 98%
“…Polysaccharides are relatively non-toxic and so have no significant side effects (Schepetkin & Quinn, 2006), therefore, they play pivotal roles in food, pharmacy and material industries (Jiao, Yu, Zhang, & Ewart, 2011). Plant polysaccharides are linked by glycosidic bonds and displayed wide biological activities, such as immunomodulation (Teng et al, 2015), anticancer (Suresh et al, 2013), antioxidation (Yang, Wang, Li, & Yu, 2015), antimicrobial (Krichen et al, 2015), and wound-healing (Lazareva et al, 2001). Anticancer activities of polysaccharides are particularly interesting to be intensively investigated.…”
Section: Introductionmentioning
confidence: 98%
“…Moreover, it has been reported that DNA of probiotic bacteria can modulate the immune responses by increasing the release of IL-10 and decreasing interleukin-1β levels [21]. Other examples of bacterial derivatives investigated as immunomodulators are bacterial polysaccharides and lipopolysaccharides, which may have modulatory effects on the immune system [22,25]. Recently, Perry et al reported that streptozolin isolated from a specific Actinomycete could substantially increase the phagocytic activity of macrophages and recruit pro-inflammatory cytokines, IL-8 and TNF-α through activating the NF-κB signaling pathway [23].…”
Section: Discussionmentioning
confidence: 99%
“…A number of studies have identified immunomodulatory compartments of microbial products such as bacterial toxins, bacterial polysaccharides and secondary metabolites that have poteintal in treating certain pathological situations [2,4,6,[17][18][19][20][21][22][23][24][25][26][27][28]. Several substances, including components of bacterial cell walls, have been reported to modulate innate immune responses [1,7,19,20].…”
Section: Discussionmentioning
confidence: 99%
“…K5 capsular polysaccharide and its chemically modified K5PSs, including O-sulfated K5PS (K5-OS), N-sulfated K5PS (K5-NS), N,Osulfated K5PS (K5-NS,OS) were obtained from our laboratory, which were prepared and analyzed as previously described [8]. K5-OS with DS (degree of substitution) of 0.33, K5-NS with DS of 0.66, and K5-NS,OS with DS of 1.04 were employed in this experiment, respectively.…”
Section: Materials and Chemicalsmentioning
confidence: 99%
“…The results show that the sulfation of K5PS significantly improved its immunostimulatory activity [8]. In addition, other researchers also found that sulfated derivatives of K5PS were endowed with different biological properties, including anticoagulant/antithrombotic, antiviral, and antitumor activities [9,10].…”
Section: Introductionmentioning
confidence: 95%