Immunomodulatory activity ofLactobacillusstrains isolated from fermented vegetables and infant stool

Abstract

Four Lactobacillus strains - Lactobacillus plantarum CJLP133, L. plantarum CJLP243, L. plantarum CJNR26, and Lactobacillus gasseri CJMF3 - were isolated from Korean fermented food or healthy infant feces, and their capacity to modulate cellular and humoral immune responses was studied. Feeding of the tested lactobacilli for 8 weeks did not alter the weight of and cell numbers in the spleen of mice. However, CJLP133 and CJLP243 strains increased the T lymphocyte population in the spleen of mice, while CJNR26 and CJMF3 increased the B lymphocyte population. In splenocytes treated with concanavalin A, ingestion of CJLP133 and CJLP243 promoted T lymphocyte proliferation and secretion of T cell cytokines, whereas feeding of the CJNR26 and CJMF3 strains enhanced B lymphocyte proliferation in splenocytes treated with lipopolysaccharide and plaque formation. These results suggest that CJLP133 and CJLP243 have immunostimulating activity through the enhancement of T cell activation, while CJNR26 and CJMF3 exhibit immunopotentiation through the increment of B cell activation.

Natural populations of lactic acid bacteria in douchi from Yunnan Province, China

“…were the predominant LAB in douchi samples collected from Yunnan, China. The 16S rDNA sequences of the four strains from southeast Yunnan and the five strains from central Yunnan were affiliated to L. plantarum which has been found to play an important role in many types of fermented food (Briggiler Marcó et al, 2011;Won et al, 2011;Zago et al, 2011). Nearly all sequences which were associated with W. paramesenteroides were detected in samples from south Yunnan, and sequences affiliated to W. confuse were detected in the samples from south and southeast Yunnan.…”

L. plantarum, L. salivarius, and L. lactis Attenuate Th2 Responses and Increase Treg Frequencies in Healthy Mice in a Strain Dependent Manner

“…Surprisingly, the number of studies investigating the immunomodulatory effects of probiotics in non-diseased subjects is limited [36]–[38]. Most studies have focused on disease models [39], with a strong perturbation of immune homeostasis and often skewing to a specific T helper cell response [39], [40].…”

Oral Combined Therapy with Probiotics and Alloantigen Induces B Cell–Dependent Long-Lasting Specific Tolerance

“…Administration of probiotics by the oral route also have been shown to modulate the immune response, favoring either pro- (13,14) or anti-inflammatory (15,16) responses. Recent studies suggest that TLRs and NF-kB signaling pathways play a crucial role in the outcome of the response (17)(18)(19)(20)(21).…”