2005
DOI: 10.1248/bpb.28.1398
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Immunomodulatory Activity of Triphala on Neutrophil Functions

Abstract: Everyone experiences stress, which results in the over secretion of glucocorticoids. 1) Increase in glucocorticoid level leads to the suppression of immune function in both humans and animals.2) Environmental stress plays an important role in the elevation of blood glucocorticoid level, which suppresses both innate as well as acquired immune functions 3,4) and results in susceptibility to infections. 5)Herbs are selected and combined for their ability to inhibit microbial overgrowth in various parts of the bod… Show more

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Cited by 110 publications
(81 citation statements)
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“…Total WBC were conducted in these groups of rats to establish their total WBC levels. Total white blood cell counts in tail blood of rats was determined by the method of Srikumar et al [13] using a Neubauer haemocytometer. Leukopenia was then induced by treating the rats with 200 mg cyclophosphamide per kilogram body weight intra-peritoneally.…”
Section: Evaluation Of the Effect Of Crude Extracts On Total Wbc Counmentioning
confidence: 99%
“…Total WBC were conducted in these groups of rats to establish their total WBC levels. Total white blood cell counts in tail blood of rats was determined by the method of Srikumar et al [13] using a Neubauer haemocytometer. Leukopenia was then induced by treating the rats with 200 mg cyclophosphamide per kilogram body weight intra-peritoneally.…”
Section: Evaluation Of the Effect Of Crude Extracts On Total Wbc Counmentioning
confidence: 99%
“…The constituents of triphala were reported to enhance the antioxidant status in aging animal models (Yokozawa et al, 2007;Mahesh et al, 2009). In addition, triphala has been reported to possess several other important medicinal properties (Srikumar et al, 2005;Rasool and Sabina, 2007;Shi et al, 2008) that strengthen its potential to deal with multiple problems associated with aging. Such a multi-faceted activity of triphala is consistent with the complementary and alternative medicine concepts of a holistic approach to restore the normal balance of the three humors and supports its potential to rejuvenate the aging cells.…”
Section: Triphalamentioning
confidence: 99%
“…Apart from this, triphala has been shown to possess significant antioxidant (Naik et al, 2005;Mahesh et al, 2009;Hazra et al, 2010) and nitric oxide scavenging activity (Jagetia et al, 2004). In addition, the anti-cancer (Deep et al, 2005;Sandhya and Mishra, 2006;Shi et al, 2008), immunomodulatory (Srikumar et al, 2005) and anti-inflammatory (Rasool and Sabina, 2007) activity of triphala directly targets the common health problems associated with aging. The selective cytotoxic and apoptotic activity of triphala on cancer cells while sparing the adjacent normal cells (Shi et al, 2008) further strengthens its compelling role as a dietary supplement to promote longevity.…”
Section: Signaling Molecules That Mediate the Biological Effects Of Hmentioning
confidence: 99%
“…Upon exposure to noise stress, the neutrophil functions were reported to be suppressed in immunized rats. 12 Immunomodulation using medicinal plants is an expanding area of research. The rhizome of Acorus calamus Linn.…”
Section: Introductionmentioning
confidence: 99%