Immunomodulatory activity of β-glucan-containing exopolysaccharides from Auricularia auricular in phagocytes and mice infected with Cryptococcus neoformans

Basso, Angelina Maria Moreschi; Castro, Raffael Júnio Araújo de; Castro, T B de; Guimarães, H I; Polez, Vera Lúcia Perussi; Carbonero, Elaine R.; Pomin, Vitor H.; Hoffmann, Christian; Grossi-de-Sa, M F; Tavares, Aldo Henrique; Bocca, Anamélia Lorenzetti

doi:10.1093/mmy/myz042

Cited by 14 publications

(9 citation statements)

References 62 publications

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“…Nevertheless, their potential clinical use is of great value and is being considered in different pre-clinical experimental models and in clinical studies. β-glucans from mushrooms effectively improved the immune response or survival in different experimental models of sepsis, such as pulmonary sepsis induced by intra-tracheal administration to rats of antibiotic-resistant Klebsiella pneumoniae [ 27 ], or cryptococcal infection in mice [ 28 ]. Lentinan exerted intestinal anti-inflammatory activity in a mouse model of colitis, through inhibition of IL-8 mRNA expression [ 29 ] and improved the intestinal barrier function in piglets, decreasing rotavirus-induced diarrhea [ 30 ].…”

Section: β-Glucans Biological Effectsmentioning

confidence: 99%

“…The immunomodulatory effect of β-glucans (a syrup containing the pleuran β-glucan from Pleurotus ostreatus and vitamin C) has been tested versus vitamin C alone in a clinical trial in children with recurrent respiratory tract infections [ 28 ]: the respiratory symptoms were reduced, but the beneficial effect cannot be attributed to the β-glucans alone, rather should be related to a potentiating effect by β-glucan of vitamin C [ 31 ]. The Shiitake mushroom extract Lentinex ® given as a supplement in a cross-over, placebo-controlled trial in healthy elderly was safe and induced an increase in the number of circulating B-cells, without affecting any other immune parameter [ 32 ].…”

Section: β-Glucans Biological Effectsmentioning

confidence: 99%

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Edible Mushrooms and Beta-Glucans: Impact on Human Health

2021

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Mushroom cell walls are rich in β-glucans, long or short-chain polymers of glucose subunits with β-1,3 and β-1,6 linkages, that are responsible for the linear and branching structures, respectively. β-glucans from cereals, at variance, have no 1,6 linkages nor branching structures. Both immunomodulatory and anti-inflammatory effects of mushrooms have been described using purified β-glucans or fungi extracts on cellular and experimental models; their potential clinical use has been tested in different conditions, such as recurrent infections of the respiratory tract or complications of major surgery. Another promising application of β-glucans is on cancer, as adjuvant of conventional chemotherapy. β-glucans may protect the cardiovascular system, ameliorating glucose, lipid metabolism, and blood pressure: these activities, observed for oat and barley β-glucans, require confirmation in human studies with mushroom β-glucans. On the other hand, mushrooms may also protect the cardiovascular system via a number of other components, such as bioactive phenolic compounds, vitamins, and mineral elements. The growing knowledge on the mechanism(s) and health benefits of mushrooms is encouraging the development of a potential clinical use of β-glucans, and also to further document their role in preserving health and prevent disease in the context of healthy lifestyles.

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Section: β-Glucans Biological Effectsmentioning

confidence: 99%

Section: β-Glucans Biological Effectsmentioning

confidence: 99%

Edible Mushrooms and Beta-Glucans: Impact on Human Health

2021

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“…Activation of M1 macrophages leads to optimal fungicidal effects. M1 activity is associated with robust production of reactive oxygen and nitrogen species to establish control of the C. neoformans infection ( Basso et al., 2020 ). Conversely, M2 macrophage promotes a Th2-derived interleukin IL-4/IL-13-dominant cytokine environment, resulting in uncontrolled fungal growth, dissemination, and exacerbation of disease ( Basso et al., 2020 ).…”

Section: Macrophage Mediated Host Defense Against Cryptococ...mentioning

confidence: 99%

Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection

Wang

Pawar

Dutta

et al. 2022

Front. Cell. Infect. Microbiol.

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Macrophages are key cellular components of innate immunity, acting as the first line of defense against pathogens to modulate homeostatic and inflammatory responses. They help clear pathogens and shape the T-cell response through the production of cytokines and chemokines. The facultative intracellular fungal pathogen Cryptococcus neoformans has developed a unique ability to interact with and manipulate host macrophages. These interactions dictate how Cryptococcus infection can remain latent or how dissemination within the host is achieved. In addition, differences in the activities of macrophages have been correlated with differential susceptibilities of hosts to Cryptococcus infection, highlighting the importance of macrophages in determining disease outcomes. There is now abundant information on the interaction between Cryptococcus and macrophages. In this review we discuss recent advances regarding macrophage origin, polarization, activation, and effector functions during Cryptococcus infection. The importance of these strategies in pathogenesis and the potential of immunotherapy for cryptococcosis treatment is also discussed.

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“…Thirdly, NPs exert protective effects on cells through antioxidant mechanisms (Alam et al, 2012;Fankem et al, 2019;Reddy et al, 2010). Lastly, NPs can induce DNA damage (Singh et al, 2018), interfere with substance meta-bolism (Agarwal et al, 2008), exert immunomodulation (Basso et al, 2020) or autophagy modulation (Kaneda et al, 1991;Laconi et al, 2014).…”

Section: Nps Against Other Infectious Pathogensmentioning

confidence: 99%

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

Luo

Yang

Wang

et al. 2021

Sci. China Life Sci.

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As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products (NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range vast biological activities. A dataset comprising 618 articles, including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify 268 NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyridomycin. The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity, whereas the chemistries inhibiting bacteria, fungi, and viruses showed more structural diversity. A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources. The family Asteraceae possesses various compounds against C. neoformans , the family Anacardiaceae has compounds against Salmonella typhi , the family Cucurbitacea against the human immunodeficiency virus (HIV), and the family Ancistrocladaceae against Plasmodium . This review summarizes currently available data on NP-based antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents. Supporting Information The supporting information is available online at 10.1007/s11427-020-1959-5. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

show abstract

Immunomodulatory activity of β-glucan-containing exopolysaccharides from Auricularia auricular in phagocytes and mice infected with Cryptococcus neoformans

Cited by 14 publications

References 62 publications

Edible Mushrooms and Beta-Glucans: Impact on Human Health

Edible Mushrooms and Beta-Glucans: Impact on Human Health

Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

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