Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions

Murphy, Emma J.; Rezoagli, Emanuele; Pogue, Robert; Simonassi-Paiva, Bianca; Abidin, Ismin Izwani Zainol; Fehrenbach, Gustavo Waltzer; O'Neil, Emer; Major, Ian; Laffey, John G.; Rowan, Neil J.

doi:10.1016/j.scitotenv.2021.152177

Cited by 33 publications

(21 citation statements)

References 83 publications

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“…Digital transformation can also advance bioprospecting of key bioactives from microalgae, duckweed and other peatlands resources for one health application. For example, AI can be used to potentially screen and inform the appropriate type of bioactives that elicit pro-and antiinflammatory responses for fish welfare with view to fortification of feed (Murphy et al, 2020a;Murphy e al., 2020b;Murphy et al, 2022;Pogue et al, 2021). Masterson et al (2020) reported on the use of lentinan from Shiitake mushroom to ameliorate against clinical isolates of Klebsiella pneumoniae exhibiting antimicrobial resistance using novel lung infection models.…”

Section: Artificial Intelligence and Machine Learningmentioning

confidence: 99%

Digital transformation of peatland eco-innovations (‘Paludiculture’): Enabling a paradigm shift towards the real-time sustainable production of ‘green-friendly’ products and services

Rowan

Murray

Qiao

et al. 2022

Science of The Total Environment

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Section: Artificial Intelligence and Machine Learningmentioning

confidence: 99%

Digital transformation of peatland eco-innovations (‘Paludiculture’): Enabling a paradigm shift towards the real-time sustainable production of ‘green-friendly’ products and services

Rowan

Murray

Qiao

et al. 2022

Science of The Total Environment

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“…By far the greatest mechanistic information relates to elucidating immunomodulatory potential of medicinal mushrooms [66,67]. Furthermore, important differences appear to exist in the effects of apparently similar mushroom-derived preparations, which may be due to differences in sources and extraction procedures, another poorly understood issue [65].…”

Section: Fungal Biologics: Unlocking the Potential Of Eastern Practic...mentioning

confidence: 99%

“…The diverse range of conditions for which biologics from medicinal fungi are in clinical testing underlines the incomplete understanding of the diverse mechanisms of action that is a key knowledge gap. By far the greatest mechanistic information relates to elucidating immunomodulatory potential of medicinal mushrooms [ 66 , 67 ]. Furthermore, important differences appear to exist in the effects of apparently similar mushroom-derived preparations, which may be due to differences in sources and extraction procedures, another poorly understood issue [ 65 ].…”

Section: Fungal Biologics: Unlocking the Potential Of Eastern Practic...mentioning

confidence: 99%

“…There is a pressing need to reach international consensus and agreement on the defined production methods for bioactives produced from medicinal fungi for this potential purpose as batch-to-batch variation in production methods and types of mushrooms may generated different structural-bioactives that may lead to vary functional activities [ 67 , 131 , 132 ]. This situation will be addressed by promoting international collaborations between academia and industry partners in the areas of biotechnology, mycology, toxicology, bioinformatics and biopharma.…”

Section: Pharmacological Consideration Of Mycotherapymentioning

confidence: 99%

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Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain

Meade

Hehir

Rowan³

et al. 2022

JoF

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Mushrooms have been used as traditional medicine for millennia, fungi are the main natural source of psychedelic compounds. There is now increasing interest in using fungal active compounds such as psychedelics for alleviating symptoms of mental health disorders including major depressive disorder, anxiety, and addiction. The anxiolytic, antidepressant and anti-addictive effect of these compounds has raised awareness stimulating neuropharmacological investigations. Micro-dosing or acute dosing with psychedelics including Lysergic acid diethylamide (LSD )and psilocybin may offer patients treatment options which are unmet by current therapeutic options. Studies suggest that either dosing regimen produces a rapid and long-lasting effect on the patient post administration with a good safety profile. Psychedelics can also modulate immune systems including pro-inflammatory cytokines suggesting a potential in the treatment of auto-immune and other chronic pain conditions. This literature review aims to explore recent evidence relating to the application of fungal bioactives in treating chronic mental health and chronic pain morbidities.

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“…β-glucans are heterogeneous polysaccharides extracted from organic sources such as cereals, mushrooms, seaweeds, and microorganisms [ 1 , 2 , 3 ]. Glucans have a number of unique characteristics, some of them are described below.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

Golian

Chlebová

Žiarovská

et al. 2022

JoF

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Oyster mushroom (Pleurotus ostreatus) is still one of the most cultivated edible and medicinal mushrooms. Despite its frequent cultivation around the world, there is currently just a little information available on the variability of strains in terms of the content of β-glucans in them. This work presents an extensive study of 60 strains in terms of the content of α-glucans and β-glucans in their caps and stipes. The authenticity of the production strains based on an analysis of the variability of their genome by CDDP (Conserved DNA-derived polymorphism) markers was confirmed, whereas identical CDDP profiles were identified between samples 45, 89, 95, and 96. Genetic variability of the analyzed production strains showed a high polymorphism and effective discriminative power of the used marking technique. Medium positive correlations were found among the CDDP profiles and β-glucan content in the group of strains that generated the same CDDP profiles, and low negative correlation was found among these profiles in the group of low β-glucan content strains. For the determination of glucans content, Mushroom and Yeast analytical enzymatic kit (Megazyme, Bray, Co. Wicklow, Ireland) were used. The results clearly showed that the stipe contains on average 33% more β-glucans than the cap. The minimum detected β-glucan content in the stipe was in strain no. 72, specifically 22%, and the maximum in strain no. 43, specifically 56%, which after the conversion represents a difference of 155%. From the point of view of β-glucan content, the stated strain no. 43 appears to be very suitable for the commercial production of β-glucans under certain conditions.

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Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom – A potential treatment for inflammatory lung conditions

Cited by 33 publications

References 83 publications

Digital transformation of peatland eco-innovations (‘Paludiculture’): Enabling a paradigm shift towards the real-time sustainable production of ‘green-friendly’ products and services

Digital transformation of peatland eco-innovations (‘Paludiculture’): Enabling a paradigm shift towards the real-time sustainable production of ‘green-friendly’ products and services

Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain

Analysis of Biochemical and Genetic Variability of Pleurotus ostreatus Based on the β-Glucans and CDDP Markers

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