Immunomodulatory and Anti-Inflammatory Activities of Algerian Ulva Lactuca

Abstract

Background: Secondary metabolites such as polysaccharides and

Anti-allergic effects of Ulva-derived polysaccharides, oligosaccharides and residues in a murine model of food allergy

“…In a murine model of kidney injury, oral treatment with Ulva polysaccharide extract (300 mg/kg) reduced the TNF-α production [ 41 ]. In a rat model of carrageenan-induced acute inflammation, Ulva polysaccharide extracts (100 mg/kg) attenuated paw edema and suppressed the levels of myeloperoxidase and malondialdehyde [ 42 ]. In a murine model of dextran sulfate sodium-induced inflammatory bowel disease, oral treatment with selenized Ulva polysaccharides (100 mg/kg) inhibited the infiltration of white blood cells into the intestine and the production of proinflammatory cytokines [ 22 ].…”

Immunomodulatory effects of <i>Ulva</i>-derived polysaccharides, oligosaccharides, and residues in a murine model of delayed-type hypersensitivity

“…Oral treatment with an Ulva polysaccharide extract (300 mg/kg) reduced the TNF-α production in a murine model of kidney injury [ 22 ]. In a rat model of carrageenan-induced acute inflammation, Ulva polysaccharide extracts (100 mg/kg) attenuated paw edema and suppressed the levels of myeloperoxidase and malondialdehyde [ 23 ]. Moreover, in a murine model of dextran sulfate sodium-induced inflammatory bowel disease, oral treatment with selenized Ulva polysaccharides (100 mg/kg) inhibited the infiltration of white blood cells into the intestine and the production of pro-inflammatory cytokines [ 8 ].…”

Anti-Inflammatory and Immunomodulatory Properties of a Crude Polysaccharide Derived from Green Seaweed Halimeda tuna: Computational and Experimental Evidences

“…A previous study reported that natural polysaccharides (LDP-1) extracted from the fruiting bodies of a rare wild Lactarius delicious with a molecular weight of 9.8 × 10 5 Da are non-toxic and exhibited immunological activity in the RAW 264.7 cells [63]. Another study [64] indicated that sulfate polysaccharide from green seaweed Ulva lactuca (ULPF) had no apparent toxicity toward RAW264.7 proliferations at 10-60 µg/mL. However, at 60 µg/mL, ULPF exhibited a weak cytotoxic activity on murine RAW264.7 macrophages.…”

“…Interestingly, this extract significantly increased the viability of RAW 264.7 cells, reaching 181% at a concentration of 15.6 µg/mL (Figure 5A). Thus, compounds activating macrophages promise to improve the host immune system ability [62][63][64][65].…”

“…Interestingly, this extract significantly increased the viability of RAW 264.7 cells, reaching 181% at a concentration of 15.6 µg/mL (Figure 5A). Thus, compounds activating macrophages promise to improve the host immune system ability [62][63][64][65]. A previous study reported that natural polysaccharides (LDP-1) extracted from the fruiting bodies of a rare wild Lactarius delicious with a molecular weight of 9.8 × 10 5 Da are…”