Immunomodulatory and Anti-Inflammatory Potential of Curcumin for the Treatment of Allergic Asthma: Effects on Expression Levels of Pro-inflammatory Cytokines and Aquaporins

Shahid, Hira; Shahzad, Muhammad; Shabbir, Arham; Saghir, Gulpash

doi:10.1007/s10753-019-01066-2

Cited by 47 publications

(24 citation statements)

References 34 publications

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“…The immunosuppressive properties of curcumin were reported by Gao et al, who observed, in response to curcumin treatment, impairment of spleen lymphocyte proliferation and stimulation of cytotoxic T lymphocytes that were unresponsive to activating molecules [16]. Other researchers also report the anti-inflammatory properties of curcumin in the treatment of bronchial asthma [17], suppression of macrophages in the context of inflammation-related diseases [18], and therapeutic potential in experimental autoimmune myasthenia gravis (EAMG) [19].…”

Section: Introductionmentioning

confidence: 83%

Impact of phytochemicals and plant extracts on viability and proliferation of NK cell line NK-92 – a closer look at immunomodulatory properties of goji berries extract in human colon cancer cells

Kwaśnik¹,

Lemieszek²,

Rzeski³

2021

Ann Agric Environ Med.

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Section: Introductionmentioning

confidence: 83%

Impact of phytochemicals and plant extracts on viability and proliferation of NK cell line NK-92 – a closer look at immunomodulatory properties of goji berries extract in human colon cancer cells

Kwaśnik¹,

Lemieszek²,

Rzeski³

2021

Ann Agric Environ Med.

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“…Agents with inhibitory impact on the expression and level of TGF-β are of considerable importance in asthma therapy. In respect to excellent antiinflammatory activity of curcumin, it diminishes expression of TGF-β as a pro-fibrotic cytokine to abate airway inflammation and pulmonary edema (Shahid et al, 2019).…”

Section: Asthmamentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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Immune response, proliferation, migration and angiogenesis are juts a few of cellular events that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have documented that TGF-β undergoes abnormal expression in different diseases, e.g., diabetes, cancer, fibrosis, asthma, arthritis, among others. This has led to great fascination into this signaling pathway and developing agents with modulatory impact on TGF-β. Curcumin, a natural-based compound, is obtained from rhizome and roots of turmeric plant. It has a number of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-diabetes and so on. Noteworthy, it has been demonstrated that curcumin affects different molecular signaling pathways such as Wnt/β-catenin, Nrf2, AMPK, mitogen-activated protein kinase and so on. In the present review, we evaluate the potential of curcumin in regulation of TGF-β signaling pathway to corelate it with therapeutic impacts of curcumin. By modulation of TGF-β (both upregulation and down-regulation), curcumin ameliorates fibrosis, neurological disorders, liver disease, diabetes and asthma. Besides, curcumin targets TGF-β signaling pathway which is capable of suppressing proliferation of tumor cells and invading cancer cells.

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“…In particular, curcumin's ability to attenuate airway inflammation seems to be due to the inhibition of NF-kB in the asthmatic lung tissue, which is highly involved in the pathogenesis of the disease [ 9 , 10 ]. Moreover, levels of pro-inflammatory and pro-fibrotic cytokines, chemokines, and heat shock proteins were found to be reduced by the polyphenol action, whereas aquaporin expression increased, leading to the reduction of pulmonary edema [ 11 ]. However, the low aqueous solubility is limiting for its potential therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma

et al. 2021

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Curcumin has shown a potential extraordinary activity as an add-on ingredient in asthma treatment, due to its immunomodulatory and anti-inflammatory mechanism of action. However, its low water solubility and bioavailability lead to a poor therapeutic effect, which can be overcome by its formulation as nanocrystals. The aim of this study was to prepare a multicomponent formulation for the delivery of curcumin (CUR) and beclomethasone dipropionate (BDP) into the lungs as water-based nanosuspensions (NS). Single component formulations (CUR-NS, BDP-NS) and a multicomponent formulation (CUR+BDP-NS) were prepared through a wet ball media milling technique, using P188 as a non-toxic stabilizer. Characterization was carried out in terms of size, size distribution, zeta potential, nanocrystals morphology, and solid-state properties. Moreover, the inhalation delivery efficiency was studied with Next Generation Impactor (NGI, Apparatus E Ph. Eu). CUR-NS was optimized and showed a long-term stability and improved nanocrystals apparent solubility. The three formulations exhibited a nanocrystal mean diameter in the range of 200–240 nm and a homogenous particle size distribution. Aggregation or sedimentation phenomena were not observed in the multicomponent formulation on 90 days storage at room temperature. Finally, the nebulization tests of the three samples showed optimal aerodynamic parameters and MMAD < 5 µm.

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Immunomodulatory and Anti-Inflammatory Potential of Curcumin for the Treatment of Allergic Asthma: Effects on Expression Levels of Pro-inflammatory Cytokines and Aquaporins

Cited by 47 publications

References 34 publications

Impact of phytochemicals and plant extracts on viability and proliferation of NK cell line NK-92 – a closer look at immunomodulatory properties of goji berries extract in human colon cancer cells

Impact of phytochemicals and plant extracts on viability and proliferation of NK cell line NK-92 – a closer look at immunomodulatory properties of goji berries extract in human colon cancer cells

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Pulmonary Delivery of Curcumin and Beclomethasone Dipropionate in a Multicomponent Nanosuspension for the Treatment of Bronchial Asthma

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