Immunomodulatory and antitumor activity of triterpenoid fractions from the rhizomes of Astilbe chinensis

Tu, Jue; Sun, Hongxiang; Ye, Yiping

doi:10.1016/j.jep.2008.07.007

Cited by 56 publications

(31 citation statements)

References 26 publications

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“…Furthermore, the much expected breakthrough in anticancer chemotherapy has been seriously challenged. Malignant tumors are one of the most serious diseases that damage human health in the modern world and the second largest deadly disease just after heart diseases [41], and as such, the search for newer anticancer agents remains endless. This search has, in recent times, shifted to the endophytic fungi.…”

Section: An Overview Of Anticancer Agents From Endophytic Fungimentioning

confidence: 99%

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

Omeje¹,

Ahomafor²,

Onyekaba³

et al. 2017

Natural Products and Cancer Drug Discovery

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In comparison with other natural sources like plants, highly diverse microorganisms are narrowly explored, especially with respect to their limitless potentials as repositories of exceptionally bioactive natural products. Of these organisms, fungi inhabiting tissues of plant in a noninvasive relationship (endophytic fungi) have proven undeniably useful and unmatchable as sources of potent bioactive molecules against several diseases such as cancer and related ailments. In general terms, endophytic fungi are highly prevalent organisms found in the tissue (intracellular or intercellular) of plants and at least for reasonable portion of their lives. It has been proven that virtually every plant, irrespective of habitat and climate, plays host to wide varieties of endophytes. Endophytic fungi produce metabolites produced by diferent biosynthetic pathways to that of the host plant, and this robustness equips them to synthesize unlimited structural entities and scafolds of diverse classes. Interestingly too, the cohabitation/culture of these fungi with certain bacteria ofers even stronger hopes for anticancer drug discovery. The endless need for potent drugs has necessitated the search of bioactive molecules from several sources, and endophytic fungi appear to be a recipe. This chapter is an atempt to present the current trend of research with these very promising organisms.

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Section: An Overview Of Anticancer Agents From Endophytic Fungimentioning

confidence: 99%

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

Omeje¹,

Ahomafor²,

Onyekaba³

et al. 2017

Natural Products and Cancer Drug Discovery

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show abstract

“…The left and right earlaps were cut off and punched to pieces with a diameter of 9 mm. The DTH response to DNFB was evaluated by measuring the weight difference between the right and left ears with an analytical balance [11,12]. Three organs (liver, spleen, and thymus) were also excised.…”

Section: Induction and Assessment Of Delayed-type Hypersensitivity Rementioning

confidence: 99%

“…The DTH reaction is a cell-mediated pathologic response involved with T cell activation and the production of many cytokines [11,29,30]. DNFB, an incomplete antigen, is usually smeared on the skin to evaluate the DTH reaction.…”

Section: Fed-batch Cultivation Of Adventitious Roots In the Bioreactormentioning

confidence: 99%

HPLC–ESI–MSn Analysis, Fed-Batch Cultivation Enhances Bioactive Compound Biosynthesis and Immune-Regulative Effect of Adventitious Roots in Pseudostellaria heterophylla

Wang

et al. 2015

Appl Biochem Biotechnol

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A electrospray ionization tandem mass spectrometry (ESI-MS(n)) analysis was performed in order to identify the active composition in Pseudostellaria heterophylla adventitious roots. Pseudostellarin A, C, D, and G were identified from P. heterophylla adventitious roots on the basis of LC-MS(n) analysis. The culture conditions of adventitious roots were optimized, and datasets were subjected to a partial least squares discriminant analysis (PLS-DA), in which the growth ratio and some compounds showed a positive correlation with an aeration volume of 0.3 vvm and inoculum density of 0.15 %. Fed-batch cultivation enhanced the contents of total saponin, polysaccharides, and specific oxygen uptaker rate (SOUR). The maximum dry root weight (4.728 g l(-1)) was achieved in the 3/4 Murashige and Skoog (MS) medium group. PLS-DA showed that polysaccharides contributed significantly to the clustering of different groups and showed a positive correlation in the MS medium group. The delayed-type hypersensitivity (DTH) reaction on the mice induced by 2,4-dinitrofluorobenzene (DNFB) was applied to compare the immunocompetence effects of adventitious roots (AR) with field native roots (NR) of P. heterophylla. As a result, AR possessed a similar immunoregulation function as NR.

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“…The diluted S180 cell suspension was inoculated subcutaneously into the armpit for 0.2 ml per mouse (Tu, Sun, & Ye, 2008). Twenty-four hours later, mice were divided into seven groups, each consisting of ten mice.…”

Section: Treatment and Drug Administrationmentioning

confidence: 99%

Chemical composition and antitumor activity of different polysaccharides from the roots of Actinidia eriantha

Yao

Sun

et al. 2009

Carbohydrate Polymers

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Immunomodulatory and antitumor activity of triterpenoid fractions from the rhizomes of Astilbe chinensis

Cited by 56 publications

References 26 publications

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

Endophytic Fungi as Alternative and Reliable Sources for Potent Anticancer Agents

HPLC–ESI–MSn Analysis, Fed-Batch Cultivation Enhances Bioactive Compound Biosynthesis and Immune-Regulative Effect of Adventitious Roots in Pseudostellaria heterophylla

Chemical composition and antitumor activity of different polysaccharides from the roots of Actinidia eriantha

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