Immunomodulatory and therapeutic activity of curcumin

Acute Thymic Involution and Mechanisms for Recovery

“…Treatment with these agents enhances the total number of thymocytes, thus causing an increase in the thymus weight index (Yi et al 2010), and has a protective effect against DM-induced thymocyte apoptosis in mice (Yi et al 2016). Similarly, curcumin has shown numerous therapeutic characteristics (Srivastava et al 2011). This chemical improves the immune reconstitution during carcinogenesis (Bhattacharyya et al 2007(Bhattacharyya et al , 2010 and prevents deltamethrin-induced thymocyte apoptosis by arresting the oxidative stress through caspasedependent signaling pathways (Kumar et al 2015).…”

Protective effect of curcumin against cardiac dysfunction in sepsis rats

“…CUM is a hydro-phobic polyphenol and is responsible for the yellow color of the rhizome, and has wide spectrum pharmacological activities as turmeric, such as anticancer, antiinflammatory, antibacterial, antioxidant, antirheumatic, choleretic, etc. (Anand et al, 2008a;Srivastava et al, 2011). Recently, curcumin has also been reported to show the pharmacological effects of hepatoprotective, nephroprotective, protects against myocardial infarction, suppresses thrombosis, immunomodulatory, etc.…”

Curcumin decreases astrocytic reaction after gliotoxic injury in the rat brainstem

“…Surviving astrocytes present a vigorous reaction around the injury site with increased immunoreactivity to the specific cell marker glial fibrillary acidic protein (GFAP), as well as re-expression of vimentin 3 . Curcumin (Cur) [diferuloylmethane or 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is the major yellow-orange pigment of turmeric, a common spice and coloring agent derived from the rhizome of the East Indian plant Curcuma longa, with a long history in Asian traditional cooking and medicine 5,6,7 . Recently, Cur has been shown to exhibit proven therapeutic benefits (including antioxidant, anti-inflammatory, anti-cancer and anti-fibrotic effects) in many pathological conditions, such as Alzheimer' s disease, Parkinson' s disease, multiple sclerosis, epilepsy, cerebral injury, cancer, allergy, asthma, bronchitis, colitis, rheumatoid arthritis, renal ischemia, psoriasis, scleroderma, diabetes, obesity, depression, fatigue and acquired immunodeficiency disease 6,7,8 .…”

“…Curcumin (Cur) [diferuloylmethane or 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is the major yellow-orange pigment of turmeric, a common spice and coloring agent derived from the rhizome of the East Indian plant Curcuma longa, with a long history in Asian traditional cooking and medicine 5,6,7 . Recently, Cur has been shown to exhibit proven therapeutic benefits (including antioxidant, anti-inflammatory, anti-cancer and anti-fibrotic effects) in many pathological conditions, such as Alzheimer' s disease, Parkinson' s disease, multiple sclerosis, epilepsy, cerebral injury, cancer, allergy, asthma, bronchitis, colitis, rheumatoid arthritis, renal ischemia, psoriasis, scleroderma, diabetes, obesity, depression, fatigue and acquired immunodeficiency disease 6,7,8 . Specifically regarding the CNS, Cur was capable of providing neuroprotection after spinal cord injury, inhibiting apoptosis and neuron loss and attenuating oxidative stress in astrocytes and reactive astrogliosis 9,10,11,12,13 , suggesting that Cur might beneficially affect astrocyte population in the CNS inflammatory environment by regulating both NF-κβ and SOX9 signaling pathways 14,15 .…”