2017
DOI: 10.1007/s10787-017-0349-9
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Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice

Abstract: In this study, it has been demonstrated that administration of CV has a therapeutic potential on CIA. The data suggest that CV could have a potential role in the treatment of RA patients.

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Cited by 29 publications
(12 citation statements)
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“…Cinnamomum cassia Presl is derived from the traditional Chinese medicine and is used to treat inflammatory diseases, arrhythmia, ischemia, and so on [5–8]. The essential oil can alleviate inflammation in collagen-induced arthritis in BALB/c mouse models and in Freund's adjuvant-induced paw of ICR mice [9, 10]. TCA, the main bioactive component separated from the Cinnamomum cassia Presl essential oil, possesses potent anti-inflammatory activity in aging rats, dopaminergic degeneration of mice, endothelial cells, BV2 microglia, and monocytes/macrophages [1115].…”
Section: Introductionmentioning
confidence: 99%
“…Cinnamomum cassia Presl is derived from the traditional Chinese medicine and is used to treat inflammatory diseases, arrhythmia, ischemia, and so on [5–8]. The essential oil can alleviate inflammation in collagen-induced arthritis in BALB/c mouse models and in Freund's adjuvant-induced paw of ICR mice [9, 10]. TCA, the main bioactive component separated from the Cinnamomum cassia Presl essential oil, possesses potent anti-inflammatory activity in aging rats, dopaminergic degeneration of mice, endothelial cells, BV2 microglia, and monocytes/macrophages [1115].…”
Section: Introductionmentioning
confidence: 99%
“… NFATc3, TNF-a, CAII, and mCalpain, all proteins involved in RA was inhibited. [60] 12 essential oil blends NM In vitro validated human cell cultures - Effects on the levels of protein biomarkers that are critically involved in inflammation, immune modulation, and tissue remodeling processes were exhibited. Signaling pathways such as mitotic roles of the polo-like kinase canonical pathway were affected.…”
Section: Potential Pharmacological Effects Of Cinnamon Against Covid-19mentioning
confidence: 99%
“…The future prospects of natural compounds on COVID-19 from Indonesian medicinal plants include, for example, trans-cinnamaldehyde and analogs of Cinnamomum verum as immunomodulators; 6-gingerol, 6-shogaol, and 8-shogaol of Zingiber officinale var. Rubrum as antioxidants ( Qadir et al., 2018 ); curcumin and polysaccharide as immunomodulators; phyllanthin and the related phenolic compounds of Phyllanthus niruri as immunomodulators; and polysaccharides of Oryza sativa as immunomodulators ( Yang et al., 2015 ).…”
Section: Targets For Blocking Rna Synthesis and Viral Replicationmentioning
confidence: 99%