Immunomodulatory, apoptotic and anti-proliferative potentials of sildenafil in Ehrlich ascites carcinoma murine model: In vivo and in silico insights

Morsi, Dalia; Barnawi, Ibrahim O.; Ibrahim, Hany M.; El-Morsy, Asmaa M.; Hassab, Mahmoud A. El; Latif, Heba M. Abd El

doi:10.1016/j.intimp.2023.110135

Cited by 2 publications

(1 citation statement)

References 90 publications

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“…Decreased the number of tumour cells; reduced their viability, growth rate, and ability to proliferate; and increased apoptosis [147].…”

Section: Ascites Tumourmentioning

confidence: 99%

Exploring the Multifaceted Potential of Sildenafil in Medicine

Pușcașu,

Zanfirescu,

Negreș

et al. 2023

Medicina

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Phosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive roles of PDE5, sildenafil might be useful in other pathologies. This review aims to comprehensively explore sildenafil’s therapeutic potential across medicine, addressing a gap in the current literature. Recognising sildenafil’s broader potential may unveil new treatment avenues, optimising existing approaches and broadening its clinical application.

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“…Decreased the number of tumour cells; reduced their viability, growth rate, and ability to proliferate; and increased apoptosis [147].…”

Section: Ascites Tumourmentioning

confidence: 99%

Exploring the Multifaceted Potential of Sildenafil in Medicine

Pușcașu,

Zanfirescu,

Negreș

et al. 2023

Medicina

View full text Add to dashboard Cite

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PDE5 inhibitors against cancer via mediating immune cells in tumor microenvironment: AI‐based approach for future drug repurposing exploration

Zhang,

Huang,

Feng

et al. 2024

Interdisciplinary Medicine

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Phosphodiesterase‐5 (PDE5) inhibitors are used clinically for the treatment of erectile dysfunction, pulmonary arterial hypertension, and other urological diseases. Emerging evidences have suggested the therapeutic capacity of PDE5 inhibitors as the repurposed drugs in oncology. However, the essential immune function of PDE5 inhibitors against cancer in tumor microenvironment (TME) remains unclear. This review aimed to summarize the recent advances regarding the repurposing of PDE5 inhibitors as anti‐cancer agents for cancer management to enhance the anti‐tumor immune response by mediating various immune cells, which included the myeloid‐derived suppressor cells, macrophages, T cells, fibroblasts, and natural killer cells in TME. Moreover, artificial intelligence (AI), as a new approach, is composed of traditional machine learning and deep learning methods and could be potentially used to identify the targets of immune cells in TME and predict the efficacy for repurposed drug toward malignancies. In summary, these endeavors provide novel insights into the comprehensive strategies for PDE5 inhibitors mediating immune cells against cancer and AI‐based approach for future drug repurposing exploration.

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Immunomodulatory, apoptotic and anti-proliferative potentials of sildenafil in Ehrlich ascites carcinoma murine model: In vivo and in silico insights

Cited by 2 publications

References 90 publications

Exploring the Multifaceted Potential of Sildenafil in Medicine

Exploring the Multifaceted Potential of Sildenafil in Medicine

PDE5 inhibitors against cancer via mediating immune cells in tumor microenvironment: AI‐based approach for future drug repurposing exploration

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