Immunomodulatory Effect of Cytokines in the Differentiation of Mesenchymal Stem Cells: A Review

Zahari, Wafa’; Hashim, Siti Nurnasihah Md; Yusof, Muhammad Fuad Hilmi; Osman, Zul Faizuddin; Kannan, Thirumulu Ponnuraj; Mokhtar, Khairani Idah; Ahmad, Azlina; Noordin, Khairul Bariah Ahmad Amin

doi:10.2174/1574888x11666160614103404

Cited by 17 publications

(10 citation statements)

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“…Abnormal immunoregulation by MSCs can lead to several autoimmune diseases [4]. Moreover, MSCs exert considerable therapeutic effects on several autoimmune diseases owing to their multilineage differentiation potential and highly immunoregulatory properties [23,24]. In our previous study, we found that impairment in the immunoregulatory functions of MSCs played a key role in the pathogenesis of AS [7].…”

Section: Mscs Are One Of the Most Important Immunoregulatory Cell Typmentioning

confidence: 94%

Integrating the lncRNA and mRNA expression profiles of TLR4-primed mesenchymal stem cells in ankylosing spondylitis

Huang

et al. 2020

Preprint

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Background Our previous study found that the toll-like receptor 4 (TLR4) expression of ankylosing spondylitis (AS) patients was significantly different from that of healthy donors. The goals of this study were to explore the expression profiles and functional networks of lncRNAs and mRNAs in TLR4-primed mesenchymal stromal cells from AS patients (AS-MSCs) and to clarify the mechanisms by which TLR4-primed MSCs exert immunoregulatory effects in AS. Methods Firstly, the immunoregulatory effects of MSCs were determined after TLR4 activation. Then, the differentially expressed (DE) lncRNAs and mRNAs between the control group (AS-MSCs without stimulation) and experimental group (AS-MSCs stimulated with lipopolysaccharide) were identified through high-throughput sequencing followed by qRT-PCR confirmation. Finally, bioinformatic analyses were performed to identify the critical biological functions, signalling pathways and associated functional networks involved in the TLR4-primed immunoregulatory function of AS-MSCs. Results TLR4-primed AS-MSCs showed a strong ability to inhibit the proliferation of peripheral blood mononuclear cells (PBMCs) with 1 µg/ml LPS stimulation for 4 hours. A total of 147 DE lncRNAs and 698 DE mRNAs were identified between TLR4-primed AS-MSCs and unstimulated AS-MSCs. Significant fold changes in lncRNA and mRNA levels were confirmed by qRT-PCR. GO and KEGG analysis demonstrated that the DE mRNAs and lncRNAs were highly associated with the inflammatory response. Cis-regulation prediction revealed 9 novel lncRNAs while trans-regulation prediction revealed 15 lncRNAs, respectively. Conclusions Our research describes the lncRNA and mRNA expression profiles and functional networks in TLR4-primed AS-MSCs, which is supposed to enhance the understanding of the pathogenesis of AS-MSC immunoregulatory dysfunction.

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Section: Mscs Are One Of the Most Important Immunoregulatory Cell Typmentioning

confidence: 94%

Integrating the lncRNA and mRNA expression profiles of TLR4-primed mesenchymal stem cells in ankylosing spondylitis

Huang

et al. 2020

Preprint

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“…Cytokines are synthesized mainly by the immune and nervous system and are responsible for the regulation of differentiation, inflammation, immune responses, cell apoptosis, and necrosis via transmitting signals between cells (Totsch and Sorge, 2017 ; Zahari et al, 2017 ). Additionally, cytokines contribute significantly to pain arising from nociceptor activation.…”

Section: Mechanistic Insights Into the Dialog Between Neuron And Mast Cellmentioning

confidence: 99%

Involvement of Mast Cells in the Pathophysiology of Pain

Mai

Liu

Huang

et al. 2021

Front. Cell. Neurosci.

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Mast cells (MCs) are immune cells and are widely distributed throughout the body. MCs are not only classically viewed as effector cells of some allergic diseases but also participate in host defense, innate and acquired immunity, homeostatic responses, and immunoregulation. Mounting evidence indicates that activation of MCs releasing numerous vasoactive and inflammatory mediators has effects on the nervous system and has been involved in different pain conditions. Here, we review the latest advances made about the implication of MCs in pain. Possible cellular and molecular mechanisms regarding the crosstalk between MC and the nervous system in the initiation and maintenance of pain are also discussed.

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“…During the perinatal period, ESC-derived AECs can rescue fetal lung explants from pulmonary hypoplasia and vascular rupture in vitro [ 72 ]. It is necessary to screen MSC-related markers through the laboratory and then carry out verification experiments and quantitative determination of biological activity, to lay a foundation for the application and promotion of MSCs which can affect the proliferation and function of immune cells, including dendritic cells, NK cells, and T and B lymphocytes [ 43 , 73 , 74 ]. It should be noted that tumor formation has not yet been verified after MSC treatment in vivo [ 59 , 61 , 66 ], but it does not mean that MSCs have no potential for teratogenic and carcinogenic.…”

Section: Current Challenges In Msc Treatmentmentioning

confidence: 99%

Application Prospects of Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia and the Challenges Encountered

Tong

Zuo

Yue

2021

BioMed Research International

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Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature babies, especially affecting those with very low or extremely low birth weights. Survivors experience adverse lung and neurological defects including cognitive dysfunction. This impacts the prognosis of children with BPD and may result in developmental delays. The currently available options for the treatment of BPD are limited owing to low efficacy or several side effects; therefore, there is a lack of effective treatments for BPD. The treatment for BPD must help in the repair of damaged lung tissue and promote further growth of the lung tissue. In recent years, the emergence of stem cell therapy, especially mesenchymal stem cell (MSC) therapy, has improved the treatment of BPD to a great extent. This article briefly reviews the advantages, research progress, and challenges faced with the use of MSCs in the treatment of BPD. Stem cell therapy is beneficial as it repairs damaged tissues by reducing inflammation, fibrosis, and by acting against oxidative stress damage. Experimental trials have also proven that MSCs provide a promising avenue for BPD treatment. However, there are challenges such as the possibility of MSCs contributing to tumorous growths, the presence of heterogeneous cell populations resulting in variable efficacy, and the ethical considerations regarding the use of this treatment in humans. Therefore, more research must be conducted to determine whether MSC therapy can be approved as a treatment option for BPD.

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Immunomodulatory Effect of Cytokines in the Differentiation of Mesenchymal Stem Cells: A Review

Cited by 17 publications

References 0 publications

Integrating the lncRNA and mRNA expression profiles of TLR4-primed mesenchymal stem cells in ankylosing spondylitis

Integrating the lncRNA and mRNA expression profiles of TLR4-primed mesenchymal stem cells in ankylosing spondylitis

Involvement of Mast Cells in the Pathophysiology of Pain

Application Prospects of Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia and the Challenges Encountered

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