Immunomodulatory effect of DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane) on complement system and macrophages

Dutta, Rajib; Mondal, Antara; Arora, Vivek; Nag, Tapas Chandra; Das, Nibhriti

doi:10.1016/j.tox.2008.07.063

Cited by 36 publications

(10 citation statements)

References 39 publications

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“…Our previous study suggested that some environmental endocrine disrupting chemicals, such as 17b-estradiol and permethrin, could also increase the iNOS gene transcription in zebrafish after a 3-day exposure during embryo development [11]. Similarly, Dutta et al [42] also observed that a 24-h exposure to DDT significantly (p < 0.05) enhanced the generation of NO in rat macrophages at a concentration of 100 mg/ml. In the present experiment, we found that the total NO content increased significantly in all CYP-treated groups while the mRNA levels of iNOS only increased significantly in high concentrations (3 and 10 mg/l) of CYP groups.…”

Section: Discussionmentioning

confidence: 78%

Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio)

Jin

Zheng

2011

Fish & Shellfish Immunology

153

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Section: Discussionmentioning

confidence: 78%

Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio)

Jin

Zheng

2011

Fish & Shellfish Immunology

153

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“…Immunological effects of OCs have been reported in studies conducted both in animals [13][14][15][16] and humans [17][18][19][20]. However, previous epidemiological studies on the association between OCs and LRTI have not been able to clearly determine which compound (PCBs, DDE or other OCs) was responsible for these effects due to the high correlation between concentrations of individual compounds [5,6,8].…”

mentioning

confidence: 99%

Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze

Gascón¹,

Vrijheid²,

Martínez³

et al. 2011

Eur Respir J

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The aim of our study was to examine whether pre-natal exposure to dichlorodiphenyldichloroethylene (DDE) increases the risk of lower respiratory tract infections (LRTIs) and wheeze in infants.The study is based on a birth cohort of 1,455 mother-child pairs. Maternal serum concentrations of DDE, polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB) were measured during pregnancy. Parental reports on LRTI and wheeze were obtained when children were 12-14 months old.35.4% of children developed at least one LRTI episode and 33.6% at least one wheezing episode during their first 12-14 months of life. Median DDE, PCBs and HCB concentrations were 116.3, 113.7 and 46.4 ng?g -1 lipid, respectively. DDE concentrations were associated with LRTI risk (relative risk (RR) per 10% increase 1.11, 95% CI 1.00-1.22), also after adjustment for PCBs and HCB. In all quartiles of DDE exposure, the risk of LRTI was increased compared with the lowest quartile, but the increase was statistically significant only in the third quartile (RR 1.33, 95% CI 1.08-1.62). No association was observed for PCBs and HCB. Results were similar for wheeze. This study suggests that pre-natal DDE exposure is associated with a higher risk of LRTI and wheeze in infants independently of exposure to other organochlorine compounds.

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“…Other evidence of organochlorine pesticide associations with RA includes elevated serum organochlorines in female RA cases in the National Health andNutrition Examination Survey (1999-2002) (Lee et al 2007) and experimental studies that have suggested a role for DDT in inflammatory processes and immune disruption. (Cardenas-Gonzalez et al 2013;Kim et al 2004;Dutta et al 2008). Toxaphene was associated with RA in our analyses, although the estimates were imprecise because of small numbers.…”

Section: -5mentioning

confidence: 83%

Pesticide exposure and risk of rheumatoid arthritis among licensed male pesticide applicators in the Agricultural Health Study

Meyer¹,

Parks²,

Sandler³

2016

ISEE Conference Abstracts

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BACKGROUND: The occupation of farming has been associated with rheumatoid arthritis (RA); pesticides may account for this association, but there are few studies. OBJECTIVES: We investigated associations between RA and use of pesticides in the Agricultural Health Study. METHODS: The study sample was drawn from male pesticide applicators enrolled in 1993-1997 who provided questionnaire data at baseline and at least once during follow-up (over a median 18 y; interquartile range 16-19). Incident RA cases (n = 220), confirmed by physicians or by self-reported use of disease-modifying antirheumatic drugs, were compared with noncases (n = 26,134) who did not report RA. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression, adjusting for enrollment age, state, smoking pack-years, and education. We evaluated the association of RA with the use of 46 pesticides and across 4 levels (never use and tertiles) of lifetime days of use for 16 pesticides with OR ≥1:2 for ever use. RESULTS: Incident RA was associated with ever use of fonofos (OR = 1.70; 95% CI: 1.22, 2.37), carbaryl (OR = 1.51; 95% CI: 1.03, 2.23), and chlorimuron ethyl (OR = 1.45; 95% CI: 1.01, 2.07) compared with never use. Statistically significant exposure-response trends in association with RA were observed for lifetime days of use of atrazine [OR tertile3 = 1.62 (95% CI: 1.09, 2.40); p trend = 0:01] and toxaphene [OR tertile3 = 2.42 (95% CI: 1.03, 5.68); p trend = 0:02]. Exposure-response was nonlinear for fonofos [OR tertile1 = 2.27 (95% CI: 1.44, 3.57); OR tertile2 = 0.98 (95% CI: 0.54, 1.80); OR tertile3 = 2.10 (95% CI: 1.32, 3.36); p trend = 0:005] and suggestive for carbaryl (p trend = 0:053). CONCLUSIONS: Our results provide novel evidence of associations between exposure to some pesticides and RA in male farmers.

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Immunomodulatory effect of DDT (bis[4-chlorophenyl]-1,1,1-trichloroethane) on complement system and macrophages

Cited by 36 publications

References 39 publications

Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio)

Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio)

Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze

Pesticide exposure and risk of rheumatoid arthritis among licensed male pesticide applicators in the Agricultural Health Study

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