Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells

Sugimura, T.; Jounai, Kenta; Ohshio, Konomi; Tanaka, Takaaki; Suwa, Masahiro; Fujiwara, Daisuke

doi:10.1016/j.clim.2013.10.007

Cited by 65 publications

(70 citation statements)

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“…We previously revealed that intake of JCM 5805 can activate murine pDC as well as human pDC, both in vitro and in vivo [6]. The results of that study indicated that JCM 5805 yogurt intake three times a week was associated with a reduction of approximately two-thirds in the incidence rates of influenza in schoolchildren.…”

Section: Discussionmentioning

confidence: 51%

Preventive Effect of Lactococcus lactis subsp. lactis JCM 5805 Yogurt Intake on Influenza Infection among Schoolchildren

Sakata¹,

Sasaki²,

Jounai³

et al. 2017

Health

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Objective: A community-based intervention study was conducted to examine the effect of consumption of JCM 5805 yogurt on influenza incidence rates and the cumulative incidence rates among schoolchildren in Iwate Prefecture, Japan. Methods: Schoolchildren and their parents in Shizukuishi town were told of the purpose, frequency and duration of JCM 5805 yogurt administration. The number of elementary schoolchildren in Shizukuishi town was 780 while that of junior high school students in Shizukuishi town numbered 475. The number of elementary schoolchildren in neighboring town A was 208 and that of junior high school students in town A was 121. JCM 5805 yogurt was delivered three times a week to all elementary schools and junior high schools in Shizukuishi town from January 16 through March 18, 2015. The incidence rate was calculated every week as the maximum case number divided by the number of schoolchildren in each school. The cumulative incidence rate was calculated as the total case number during the period when JCM 5805 yogurt was delivered divided by the number of schoolchildren in each school. Results: JCM 5805 yogurt intake was associated with a two-thirds reduction in influenza incidence rates in Shizukuishi town schoolchildren compared with those of town A. Furthermore, the cumulative incidence rates of the elementary school and combined data from the elementary school and junior high school were significantly lower than those of neighbor town A. Conclusion: JCM 5805 yogurt intake reduced both the incidence rates and cumulative incidence rates of influenza.

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Section: Discussionmentioning

confidence: 51%

Preventive Effect of Lactococcus lactis subsp. lactis JCM 5805 Yogurt Intake on Influenza Infection among Schoolchildren

Sakata¹,

Sasaki²,

Jounai³

et al. 2017

Health

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“…Yogurt fermented with Lactococcus lactis JCM5805 was able to activate human pDC in vivo [118], supporting a potential role of pDC in the immunity enhancing activity of probiotics.…”

Section: Pdc and Immunity To Pathogensmentioning

confidence: 88%

Human dendritic cell subsets and function in health and disease

O’Keeffe

Mok

Radford

2015

Cell. Mol. Life Sci.

168

149

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The method of choice for the development of new vaccines is to target distinct dendritic cell subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated immunity or induce tolerance to specific antigens. The innate functions of dendritic cells themselves may also be targeted by inhibitors or activators that would target a specific function such as interferon production, potentially important in autoimmune disease and chronic viral infections. Importantly targeting dendritic cells requires detailed knowledge of both the surface phenotype and function of each dendritic cell subset, including how they may respond to different types of vaccine adjuvants, their ability to produce soluble mediators and to process and present antigens and induce priming of naïve T cells. This review summarizes our knowledge of the functional attributes of the human dendritic cell subsets in the steady state and upon activation and their roles in human disease.

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“…The clinical symptoms improved in 84% of the treatment group, and the concentrations of TNF-α and IL-6 decreased, while concentrations of IL-10 and IL-2 increased in the treatment group. Also immune regulation through interferon production could be modified (at least in vitro) with probiotics (Sugimura et al, 2013;Weiss et al, 2011).…”

Section: Probiotics In Viral Hepatitismentioning

confidence: 99%