Immunomodulatory effect of pachymaran on cyclosporine A (CsA)-induced lung injury in mice

Chen, Kaiqin; Ke, Wei; Yuan, Chun; Tianhao, Zhao; Zhang, Bo; Xiao, Rong; Fangguo, Lu

doi:10.1016/j.dcmed.2022.06.011

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…After three days of adapted feeding, 60 mice were randomly divided into four groups: the control group (control), the model group (model), the Ma Xing Shigan decoction (MXSGD) and a fuzheng granule group (FZG), with 15 mice in each group. For 7 days, the hypoimmunity lung injury model was injected intraperitoneally with 45mg/kg CsA 0.2ml ( 13 ), while the control group was given the same dose of PBS. After 7 days, MXSGD and FZG were administered intragastrically for 7 days, while the other groups received the same amount of PBS ( Figure 1 ).…”

Section: Experiments Model and Materialsmentioning

confidence: 99%

MXSGD alleviates CsA-induced hypoimmunity lung injury by regulating microflora metabolism

Ye,

Gao,

Bie

et al. 2024

Front. Immunol.

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ContextMa Xing Shi Gan Decoction (MXSGD) is a traditional remedy for treating lung injuries that was developed by the Typhoid and Fever School of Pharmaceutical Biology. It has antitussive and expectorant effects, anti-inflammatory, antiviral, regulates the body’s immunity, etc.AimThe aim of this study is to investigate whether MXSGD can ameliorate cyclosporine A (CsA)-induced hypoimmunity lung injury by regulating microflora metabolism. Methods: Establishment of a model for CsA-induced hypoimmunity lung injury. Using 16S rRNA high-throughput sequencing and LC-MS, the effects of MXSGD on gut flora and lung tissue microecology of mice with CsA-induced hypoimmunity were investigated.ResultsMXSGD was able to preserve lung tissue morphology and structure, reduce serum inflammatory marker expression and protect against CsA-induced lung tissue damage. Compared to the model, MXSGD increased beneficial gut bacteria: Eubacterium ventriosum group and Eubacterium nodatum group; decreased intestinal pathogens: Rikenellaceae RC9 intestinal group; reduced the abundance of Chryseobacterium and Acinetobacter, promoted the production of Lactobacillus and Streptococcus, and then promoted the lung flora to produce short-chain fatty acids. MXSGD was able to enhance the expression of serum metabolites such as Americine, 2-hydroxyhexadecanoylcarnitine, Emetine, All-trans-decaprenyl diphosphate, Biliverdin-IX-alpha, Hordatin A and N-demethyl mifepristone in the CsA-induced hypoimmunity lung injury model.ConclusionMXSGD can restore gut and lung microbiota diversity and serum metabolite changes to inhibit inflammation, ameliorate CsA-induced hypoimmunity lung injury.

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Section: Experiments Model and Materialsmentioning

confidence: 99%

MXSGD alleviates CsA-induced hypoimmunity lung injury by regulating microflora metabolism

Ye,

Gao,

Bie

et al. 2024

Front. Immunol.

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“…The immunosuppression caused by cyclosporine, which was observed in the group of animals (T2), resulted from the inhibition of the activity of calcineurin phosphatase, which causes a decrease in the synthesis of many interleukins such as IL-2, IL-3, IL-4, and IL-6, where the results agreed with what he mentioned. [24] who reported a decrease in IL-6 in rats treated with cyclosporin A (CsA). The different letters in the same column indicate that there are significant differences between the rates at a significant level of 0.05.…”

Section: Effect Of Se-nps and Se-nps + Zinc In Immunosuppressed Rats ...mentioning

confidence: 99%

Determining the Efficacy of Selenium Nanoparticles (Se-NPs) Conjugated with Zinc and Synthesized Using Aspergillus niger on some Immunological Parameters of Induced Immunosuppressed Rats

Abd Al-Aziz,

Thalij,

Zakaria

2023

IOP Conf. Ser.: Earth Environ. Sci.

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This research was aimed to isolation and identification of Aspergillus niger from different location of garden in Tikrit university, to used in Se-NPs synthesis alone and conjugated with Zn, then its characterizes by detected the spectroscopy, shape and size of the nanoparticles, also determine the efficacy each of Se-NPs or Zn alone or after conjugated when orally dosage to laboratory rats that’s induced immunosuppressed by sandimmune on IgA, IgG and IL-6. The results were found that ability to isolated and identified the Aspergillus niger from different sites in the gardens of the Tikrit University. The synthesis of Se-NPs were obtained by converting sodium selenite (Na2SeO4) used the Aspergillus niger extract, also they obtained the Se-NPs conjugated with Zn. The confirm of synthesis were inferred through the color was changed to oranges. The value of these particles alone or their genera appeared at a wavelength of 262 and 269 nm, respectively. The scanning electron microscope (SEM) showed spherical particle shapes and sizes at 52.90 nm which were confirmed by X-ray diffraction. The orally dosage of Se-NPs for male laboratory rats alone or in combination induced immunusupressed affected the renormalization of IgA, IgG, and IL-6 t. Their normal levels of IgA at 205, 215 and 242 (mg/dL) and the IgG at 1019, 1046 and 1346 (mg/dL) while of IL-6 at 3.60, 4.13 and 6.63 (pmol/mL) respectively. These effect were refered the parameters to became equalized with their values in the group of control animals and returned to normal.

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Immunomodulatory effect of pachymaran on cyclosporine A (CsA)-induced lung injury in mice

Cited by 2 publications

References 21 publications

MXSGD alleviates CsA-induced hypoimmunity lung injury by regulating microflora metabolism

MXSGD alleviates CsA-induced hypoimmunity lung injury by regulating microflora metabolism

Determining the Efficacy of Selenium Nanoparticles (Se-NPs) Conjugated with Zinc and Synthesized Using Aspergillus niger on some Immunological Parameters of Induced Immunosuppressed Rats

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