Immunomodulatory effect of polysaccharides isolated from Lonicera japonica Thunb. in cyclophosphamide-treated BALB/c mice

Zhang, Tao; Liu, Hongping; Ma, Pengcheng; Huang, Jian; Bai, Xinyu; Liu, Ping; Li, Zhu; Min, Xun

doi:10.1016/j.heliyon.2022.e11876

Cited by 12 publications

(7 citation statements)

References 45 publications

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“…IL-10 is generally considered as a protective cytokine that promotes immune regulation, and IL-17 is involved in host defense against fungi, extracellular bacteria, and other eukaryotes [39,40]. Previous studies have shown that the effects of polysaccharides on improving immune function are closely associated to their ability to promote cytokine secretion [3,[41][42][43][44]. In our experiments, COP1 significantly upregulate cytokine (IL-10, IL-17, IL-12, IL-1β, and TNF-α) production of the spleen and ileum, which could help immunocompromised mice restored.…”

Section: Discussionmentioning

confidence: 99%

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Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice

Zhang

Tang

Cai

et al. 2023

Oxidative Medicine and Cellular Longevity

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To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1. The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY. COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions. Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway. Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function. This study suggests that COP1 may provide an alternative strategy for alleviating chemotherapy-induced immunosuppression.

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Section: Discussionmentioning

confidence: 99%

“…Immunosuppression is one of the side effects of CY, and patients are susceptible to invasive fungal infections, which can be life-threatening [2]. In recent years, many naturally active substances with low toxic effects on the host have been proven to repair the immune deficiency induced by CY [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice

Zhang

Tang

Cai

et al. 2023

Oxidative Medicine and Cellular Longevity

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“…The result showed that the linkages of LJW0F2 consisted of terminal glucose; 1,4-linked glucose; and 1,4,6-linked glucose in the molar ratio of 1:14:1 [ 47 ]. In addition, there was a neutral-fraction LJP-N that was a starch-like glucan with some arabinogalactan or arabinan domains [ 37 ]. Another homogeneous heteropolysaccharide, LJCP-2b, mainly consisted of 1,3,6- β -d-Gal p ; 1,4- α -d-Glc p ; 1,4,6- α -d-Glc p ; 1,4- β -d-Gal p ; 1,2,4- α -l-Rha p ; and 1,4- α -d-Gal p A [ 56 ].…”

Section: Structural Characteristics Of L Japonica ...mentioning

confidence: 99%

“…In addition, both LJP-N and LJP-A enhanced the cytotoxic activity of natural killer (NK) cells. However, the apoptosis rate of YAC-1 cells (the targets of NK cells) in the LJP-A-treated mice was higher than that in the LJP-N-treated mice [ 37 ]. In a similar study, LJP-d, a polysaccharide extracted from L. japonica using EAE, improved the immune function in CTX-induced immunosuppressed mice.…”

Section: Health Benefits Of L Japonica Polysacchar...mentioning

confidence: 99%

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Yang,

Yu,

et al. 2023

Molecules

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Lonicera japonica Thunb. is a widely distributed plant with ornamental, economic, edible, and medicinal values. L. japonica is a phytoantibiotic with broad-spectrum antibacterial activity and a potent therapeutic effect on various infectious diseases. The anti-diabetic, anti-Alzheimer’s disease, anti-depression, antioxidative, immunoregulatory, anti-tumor, anti-inflammatory, anti-allergic, anti-gout, and anti-alcohol-addiction effects of L. japonica can also be explained by bioactive polysaccharides isolated from this plant. Several researchers have determined the molecular weight, chemical structure, and monosaccharide composition and ratio of L. japonica polysaccharides by water extraction and alcohol precipitation, enzyme-assisted extraction (EAE) and chromatography. This article searched in the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, and CNKI databases within the last 12 years, using “Lonicera. japonica polysaccharides”, “Lonicera. japonica Thunb. polysaccharides”, and “Honeysuckle polysaccharides” as the key word, systematically reviewed the extraction and purification methods, structural characteristics, structure-activity relationship, and health benefits of L. japonica polysaccharides to provide insights for future studies. Further, we elaborated on the potential applications of L. japonica polysaccharides in the food, medicine, and daily chemical industry, such as using L. japonica as raw material to make lozenges, soy sauce and toothpaste, etc. This review will be a useful reference for the further optimization of functional products developed from L. japonica polysaccharides.

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“…Honeysuckle (Lonicera japonica Thunb) is an important medicinal and edible plant. Its flowers are rich in chlorogenic acid, luteolin, and polysaccharide, which are widely used in traditional Chinese medicine to treat cold, respiratory tract infection, sore throat and headache (1)(2)(3). The food industry also often uses honeysuckle flowers to produce plant drinks or tea alternatives (4).…”

Section: Introductionmentioning

confidence: 99%

Characterization of polysaccharide from Lonicera japonica Thunb leaves and its application in nano-emulsion

Liu

Yang

et al. 2023

Front. Nutr.

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The polysaccharides in honeysuckle leaves (PHL) were separated and characterized for the first time. The nano-emulsion stabilized by PHL and whey protein isolate (WPI) were also fabricated based on the ultrasonic method. The results indicated that PHL was mainly composed of glucose (47.40 mol%), galactose (19.21 mol%) and arabinose (20.21 mol%) with the weight-average molecular weight of 137.97 ± 4.31 kDa. The emulsifier concentration, WPI-to-PHL ratio, ultrasound power and ultrasound time had significant influence on the droplet size of PHL-WPI nano-emulsion. The optimal preparation conditions were determined as following: emulsifier concentration, 1.7%; WPI/PHL ratio, 3:1; ultrasonic power, 700 W; ultrasonic time, 7 min. Under the above conditions, the median diameter of the obtained nano-emulsion was 317.70 ± 5.26 nm, close to the predicted value of 320.20 nm. The protective effect of PHL-WPI emulsion on β-carotene against UV irradiation was superior to that of WPI emulsion. Our results can provide reference for the development of honeysuckle leaves.

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Immunomodulatory effect of polysaccharides isolated from Lonicera japonica Thunb. in cyclophosphamide-treated BALB/c mice

Cited by 12 publications

References 45 publications

Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice

Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Characterization of polysaccharide from Lonicera japonica Thunb leaves and its application in nano-emulsion

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