Immunomodulatory Effect of the Aqueous Extract of &lt;i&gt;Erigeron floribundus&lt;/i&gt; (Kunth) Sch Beep (Asteraceae) Leaf in Rabbits

Yapo, FA; Yapi, FH; Ahiboh, Hugues; Hauhouot-Attounbre, M-L; Guédé, NZ; Djaman, JA; Monnet, D

doi:10.4314/tjpr.v10i2.66562

Cited by 16 publications

(20 citation statements)

References 15 publications

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“…Their nomenclature was in accordance with Adams [22]. 2 Linear retention index on HP-5MS and DB-Wax column, experimentally determined using homologous series of C8-C30 alkanes. 3 Linear retention index taken from Adams [22] and/or NIST08 [23] for apolar columns, and from FFNSC2 [24] and/or NIST08 for polar columns.…”

Section: Essential Oil Analysismentioning

confidence: 99%

“…1 IC 50 = the concentration of compound that affords a 50% reduction in cell growth (after 72 h of incubation). 2 Human malignant melanoma cell line. 3 Human breast adenocarcinoma cell line.…”

Section: Cytotoxicity Assessmentmentioning

confidence: 99%

“…(Asteraceae) is an herbaceous plant, 1.5 m in height, with pubescent, lanceolate leaves and flowers in yellowish panicles. In Cameroon, it is commonly found as a weed along roadsides, and it is widely used in folk medicine to treat angina, female infertility, AIDS, dental pain, headache and various diseases of microbial and non-microbial origin [1][2][3][4][5][6]. The leaf aqueous extract was proven to possess analgesic, anti-inflammatory and immunomodulatory activity [1,2], the dichloromethane extract inhibition against dermatophytes [7], and the leaf ethanolic and pentane extract antiplasmodial activity [8].…”

Section: Introductionmentioning

confidence: 99%

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Biological Activities of the Essential Oil from Erigeron floribundus

et al. 2016

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Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study, we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (inhibition zone diameter, IZD of 14 mm, minimum inhibitory concentration, MIC of 512 µg/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC 50 of 98 µg/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC 50 values of 33.5 µg/mL with the essential oil and 5.6 µg/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC 50 value of 14.89 µg/mL, and remarkable ferric reducing antioxidant power (tocopherol-equivalent antioxidant capacity, TEAC = 411.9 µmol·TE/g).

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Section: Essential Oil Analysismentioning

confidence: 99%

Section: Cytotoxicity Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biological Activities of the Essential Oil from Erigeron floribundus

et al. 2016

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show abstract

“…(Asteraceae) is an herbaceous plant, 1.5 m in height, with pubescent, lanceolate leaves and flowers in yellowish panicles. In Cameroon it is commonly found as a weed along roadsides and it is widely used in the folk medicine to treat angina, female infertility, AIDS, dental pain, headache and various diseases of microbial and non-microbial origin [1][2][3][4][5][6]. The leaf aqueous extract was proven to possess analgesic, anti-inflammatory and immunomodulatory activity [1,2], the dichloromethane extract inhibition against dermatophytes [7], the leaf ethanolic and pentane extracts antiplasmodial activity [8].…”

Section: Introductionmentioning

confidence: 99%

Biological Activities of the Essential Oil from <em>Erigeron floribundus</em>

Petrelli¹,

Orsomando

Sorci

et al. 2016

Preprint

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Erigeron floribundus (Asteraceae) is an herbaceous plant widely used in the Cameroonian traditional medicine to treat various diseases of microbial and non-microbial origin. In the present study we evaluated the in vitro biological activities displayed by the essential oil obtained from the aerial parts of E. floribundus, namely the antioxidant, antimicrobial and antiproliferative activities. Moreover, we investigated the inhibitory effects of E. floribundus essential oil on nicotinate mononucleotide adenylyltransferase (NadD), a promising new target for developing novel antibiotics, and Trypanosoma brucei, the protozoan parasite responsible for Human African trypanosomiasis. The essential oil composition was dominated by spathulenol (12.2%), caryophyllene oxide (12.4%) and limonene (8.8%). The E. floribundus oil showed a good activity against Staphylococcus aureus (IZD of 14 mm, MIC of 512 µg/mL). Interestingly, it inhibited the NadD enzyme from S. aureus (IC50 of 98 µg/mL), with no effects on mammalian orthologue enzymes. In addition, T. brucei proliferation was inhibited with IC50 values of 33.5 µg/mL with the essential oil and 5.6 µg/mL with the active component limonene. The essential oil exhibited strong cytotoxicity on HCT 116 colon carcinoma cells with an IC50 value of 14.89 µg/mL, and remarkable ferric reducing antioxidant power (TEAC= 411.9 μmol TE/g).

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“…The levels of neutrophils in two treatment groups showed significant increase. Immunomodulatory effect of aqueous extract of Erigeron floribundus (Kunth) leaves stimulated increase of neutrophils and lymphocytes in rabbit blood (16). Immunological effects of Teucrium polium on neutrophil had shown an increase in the neutrophils activity and improvement in their functions (17).…”

mentioning

confidence: 99%

The effects of hydro-alcoholic extract of Artemisia dracunculus L. (Tarragon) on hematological parameters in mice

Mahkam

Zarasvand

Madani

2018

JBRMS

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Introduction: Artemisia dracunculus L. (Tarragon) is one of the plants that uses as meal and remedy for a long time, and possesses many medicinal properties. In traditional medicine also has mentioned to its beneficial properties. A number of researches through in vitro and in vivo studies showed the pharmacological properties of this plant. This study was done for determining the effect of hydro-alcoholic extract of A. Dracunculus L. on some hematological parameters among mice. Materials and methods: In this study, 40 male mice were divided into five groups: a control, a placebo, and three treatment groups that were injected with 50, 100, and 200 mg/kg doses of hydro-alcoholic extract of tarragon every other day for 20 days. At the end of injections, the levels of WBC, RBC, lymphocytes, monocytes, and neutrophils were measured. Statistical analysis was done using SPSS software and analysis of variance (ANOVA) test. Results:The obtained results showed that there was no significant difference in amounts of WBC, RBC, and monocytes in the treatment groups in comparison with the control group. Lymphocytes showed significant decrease in groups of 100 and 200 mg/kg doses than the control group. The level of neutrophils showed significant increase in two treatment groups (100 and 200 mg/kg) than the control group. Conclusion: It can be concluded that the hydro-alcoholic extract of tarragon stimulates the production of neutrophils in this study which can be used as an immunostimulating agent.

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Immunomodulatory Effect of the Aqueous Extract of <i>Erigeron floribundus</i> (Kunth) Sch Beep (Asteraceae) Leaf in Rabbits

Cited by 16 publications

References 15 publications

Biological Activities of the Essential Oil from Erigeron floribundus

Biological Activities of the Essential Oil from Erigeron floribundus

Biological Activities of the Essential Oil from <em>Erigeron floribundus</em>

The effects of hydro-alcoholic extract of Artemisia dracunculus L. (Tarragon) on hematological parameters in mice

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