Immunomodulatory effects of chromium (III) in ruminants: A review of potential health benefits and effects on production and milk quality

Mallard, Bonnie A.; Borgs, Peter; Ireland, M.J.; McBride, B.W.; Brown, B.D.; Irwin, Jennifer A.

doi:10.1002/(sici)1520-670x(1999)12:2<131::aid-jtra10>3.0.co;2-l

Cited by 3 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the IVGTT suggested that supplemental Cr feeding might be effective in increasing glucose disposal after an intravenous glucose loading in goats. Carbohydrate loading is considered to be a stressor that increases glucose metabolism, accelerates Cr mobilization and depletes body stores of Cr (Mallard et al 1999). Under such a situation, supplemental Cr is presumed to play a supportive role in maintaining tissue responsiveness to insulin and preventing hyperinsulinaemia.…”

Section: Discussionmentioning

confidence: 99%

Effects of incremental dietary chromium (Cr³⁺) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)

et al. 2006

View full text Add to dashboard Cite

Castrated male black Bengal kids were supplemented daily with 0, 0·5, 1·0, 1·5 and 2·0 mg chromium (Cr3+ as chromic chloride hexahydrate) for 150 days. Metabolic stresses such as a feeding challenge, an intravenous glucose tolerance test (IVGTT) and a short-term (72 h) feed deprivation were imposed on the animals to ascertain if supplemental Cr could alleviate these stresses and whether the stress-alleviating effect could provide an explanatory basis for the performance traits of the supplemented animals. The kids were fed with a concentrate diet containing 0·197 mg Cr/kg DM. DM intake (g/kgw0·75) was lower (P=0·006) in the 0·5 and 1·5 mg groups. Feed efficiency tended (P=0·086) to improve in the Cr-supplemented kids, although a distinct dose response was absent. Basal serum T3 increased linearly (P=0·01) with increased dose of Cr although the post-prandial change did not follow any definite trend. Basal serum insulin increased (P=0·001) linearly while the post-prandial increment was higher (P=0·037) in the control group. The IVGTT indicated that the kids supplemented with 1·5 mg Cr had significantly (P<0·05) higher serum clearance rate and lower half-life for insulin. Serum Cr during the IVGTT declined (P<0·05) until 45 m after glucose infusion and then increased again (P<0·10) at 60 m in the 0·5 and 1·5 mg groups although in the rest of the experimental groups serum Cr was stable during the entire course of the IVGTT. The body weights at the beginning of the fast were higher (P=0·036) in the kids supplemented with 0·5 and 1·5 mg Cr. However, the change in body weight at the end of the 72 h fast did not vary (P>0·10) between the groups. Cr supplementation reduced (P<0·05) serum cortisol level in the supplemented animals consistently throughout the duration of the feed deprivation. Moreover, as the fast progressed serum cortisol tended to increase (P=0·059) in all the experimental groups irrespective of the level of Cr supplementation. It was concluded that inorganic Cr supplementation might appreciably increase serum T3 concentration and reduce the level of cortisol which might augment animal productivity. However, further research with a more sensitive design is required to establish the exact level of Cr supplementation for enhancing performance of livestock.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of incremental dietary chromium (Cr³⁺) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)

et al. 2006

View full text Add to dashboard Cite

show abstract

Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs

Dallago

McManus

Caldeira

et al. 2013

Biol Trace Elem Res

View full text Add to dashboard Cite

The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days. The base ration was Panicum maximum cv Massai hay and concentrate. Blood samples were collected fortnightly for total and differential leukocyte counts. On days 28 and 56, the lambs were challenged with chicken ovalbumin I.M. Serum samples were collected on days 46 and 74 and subjected to an indirect enzyme-linked immunosorbent assay to measure IgG anti-ovalbumin. The cell-mediated immune response was determined by a delay-type hypersensitivity test using phytohemagglutinin. CrPic did not significantly affect humoral immunity in lambs but there was a negative effect on cellular immunity (P < 0.05) as Cr supplementation increased. Therefore, the level of Cr supplementation for lambs must be better studied to address its effect on stressed animals or the possible toxic effects of Cr on the animal itself or its immune system.

show abstract

Progress in chromium research and related diseases

Tao

2019

AIP Conference Proceedings

View full text Add to dashboard Cite

Immunomodulatory effects of chromium (III) in ruminants: A review of potential health benefits and effects on production and milk quality

Cited by 3 publications

References 52 publications

Effects of incremental dietary chromium (Cr³⁺) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)

Effects of incremental dietary chromium (Cr³⁺) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)

Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs

Progress in chromium research and related diseases

Contact Info

Product

Resources

About

Immunomodulatory effects of chromium (III) in ruminants: A review of potential health benefits and effects on production and milk quality

Cited by 3 publications

References 52 publications

Effects of incremental dietary chromium (Cr3+) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)

Effects of incremental dietary chromium (Cr3+) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)

Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs

Progress in chromium research and related diseases

Contact Info

Product

Resources

About

Effects of incremental dietary chromium (Cr³⁺) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)

Effects of incremental dietary chromium (Cr³⁺) on growth, hormone concentrations and glucose clearance in growing goats (Capra hircus)