Immunomodulatory effects of cigarette smoke

Sopori, Mohan L.; Kozak, Wiesław

doi:10.1016/s0165-5728(97)00231-2

Cited by 301 publications

(243 citation statements)

References 91 publications

Supporting

Mentioning

210

Contrasting

Unclassified

Order By: Relevance

“…Severe immunosuppression such as bone marrow transplantation and human immunodeficiency virus infection is a known risk factor in novel influenza A (H1N1) virus infection (2), and hypoalbuminemia is generally known to be a poor prognostic factor in bacterial and viral infections. However, asymptomatic immunosuppression such as mild hypogammaglobulinemia, which was seen in smokers like the current case (15,16), has not yet been identified as a risk. A low body weight and gastrointestinal disorders are common in smokers (17)(18)(19), as was also observed in the current case.…”

Section: Discussionmentioning

confidence: 79%

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

et al. 2010

View full text Add to dashboard Cite

A 49-year-old female presented with diarrhea and a high fever followed by progressive dyspnea. Until this presentation, she had been healthy except for chronic dyspepsia and diarrhea. She had a smoking habit of 15 pack-years. Laboratory tests revealed lymphopenia, hypoalbuminemia and hypogammaglobulinemia. A rapid influenza test in combination with an RT-PCR assay revealed the presence of the novel influenza A (H1N1) virus. Chest computed tomography revealed centrilobular emphysema. This report suggests that regular smoking may become a risk for severe pneumonia in patients presenting with the novel influenza A (H1N1) virus, when accompanying asymptomatic emphysema is combined with other problems such as hypoalbuminemia and hypogammaglobulinemia.

show abstract

Section: Discussionmentioning

confidence: 79%

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

et al. 2010

View full text Add to dashboard Cite

show abstract

“…However, chronic exposure to tobacco smoking or nicotine is thought to be related to lymphomagenesis through induction of T-cell anergy. 35 Among the limitations of our study, there is its small sample size, which does not allow to adequately address subgroups or interactions. An additional potential limitation is the use of hospital controls, which may differ from the general population in relation to their smoking habits.…”

Section: Discussionmentioning

confidence: 95%

“…EMC is characterized by cutaneous vasculitis, nephritis, peripheral neuropathy and clonal B-cell lymphoproliferations, which can evolve into NHL. 27 Tobacco smoke contains substances shown to be leukemogens, 1,34 to have immunomodulatory effects 35 and to decrease the serum levels of some immunoglobulins. 36,37 Tobacco and HCV seem therefore to act at different stages of the process of NHL carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Smoking and non‐Hodgkin lymphoma: Case‐control study in Italy

Talamini

Polesel

Montella

et al. 2005

Intl Journal of Cancer

View full text Add to dashboard Cite

Tobacco smoking is a well-documented risk factor for several cancers, but the role of cigarette smoking in the etiology of non-Hodgkin lymphoma (NHL) is inadequately understood. Hepatitis C virus (HCV) has been associated with NHL, but the interaction between HCV and smoking habits has not yet been studied. Between 1999 and 2002, we conducted a case-control study on the association of HCV, smoking habits and NHL in 2 areas of northern and southern Italy. Cases were 225 consecutive patients (median age, 59 years) with a new diagnosis of NHL that were admitted to reference and general hospitals. Controls were 504 patients (median age, 63 years) admitted to the same hospitals as cases, for a wide spectrum of acute, nonneoplastic, nonimmune-, nor tobacco-related conditions. Current, heavy smokers (!20 cigarettes/day) had an odds ratio (OR) of NHL of 2.10 (95% confidence interval, CI: 1.07-4.12) compared to never smokers. The association between smoking and NHL was consistent across strata of sex and age. Compared to never smokers, current smokers of !20 cigarettes/day had ORs of 1.14 (95% CI: 0.37-3.56) for B-cell-low-grade, 2.10 (95% CI: 0.94-4.67) for B-cell-intermediate and high-grade, and 25.84 (95% CI: 1.95-342.17) for T-cell NHL. The effect of tobacco smoking and HCV were independent on the relative risk, leading a 4-fold elevated risk in current smokers HCV positive subjects. Tobacco smoking and hepatitis C virus (HCV) have been associated to non-Hodgkin lymphoma (NHL), but the interaction between HCV and smoking habits has not yet been studied. Our study confirms that tobacco is related to NHL, and reports on the combined effect of tobacco smoking and HCV. Infection acted together according to a multiplicative model, leading to a 4-fold elevated risk in current smokers HCV positive subjects. ' 2005 Wiley-Liss, Inc.

show abstract

“…It has been postulated that nAChR activation might have adverse consequences on immune function (Sopori and Kozak, 1998). These receptors are expressed in peripheral blood cells where chronic nicotine exposure upregulates nAChR number just as it does on CNS neurons (Benhammou et al, 2000).…”

Section: Role In Signalingmentioning

confidence: 99%

Nicotinic receptor signaling in nonexcitable cells

2002

View full text Add to dashboard Cite

ABSTRACT:The finding that neuronal nicotinic acetylcholine receptors (nAChRs) are present in nonneuronal cells both within and outside the nervous system raises some interesting issues. The mechanisms underlying receptor signaling and its downstream consequences in these cells remain to be elucidated. Factors controlling the release of acetylcholine and the extent of its diffusion are likely to be different for these cells than for traditional neuronal synapses. Recent advances on the physiologic functions of some of these cell types have provided a better insight into possible functional roles for nAChRs in nonexcitable cells. The presence of nAChRs on these cells also implies a broader scope for the actions of nicotine that needs to be considered from a clinical viewpoint. Revealing the potential physiologic roles for nAChRs on nonexcitable cells is likely to provide a more complete understanding of cholinergic signaling.

show abstract

Immunomodulatory effects of cigarette smoke

Cited by 301 publications

References 91 publications

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

Smoking and non‐Hodgkin lymphoma: Case‐control study in Italy

Nicotinic receptor signaling in nonexcitable cells

Contact Info

Product

Resources

About