Immunomodulatory effects of exopolysaccharides produced by Bacillus licheniformis and Leuconostoc mesenteroides isolated from Korean kimchi

Kook, Sun-Young; Lee, Yaelim; Jeong, Eui-Cheon; Kim, Seokjin

doi:10.1016/j.jff.2019.01.003

Cited by 47 publications

(26 citation statements)

References 43 publications

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“…The EPS from Bacillus licheniformis BioE-BL11 and Lactobacillus mesenteroides BioE-LMD18 (Korean Kimchi) showed inhibition in secretion of proinflammatory cytokine IL-6 in LPS stimulated RAW264.7 mouse macrophages and enhanced secretion of the anti-inflammatory cytokine IL-10 in dose dependent manner. This property encourages EPS to be employed in food, cosmetic and pharmaceutical industries [83]. The study conducted with EPS obtained from isogenic Bifidobacterium animalis subsp.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Exopolysaccharides from probiotic bacteria and their health potential

Angelin

Kavitha

2020

International Journal of Biological Macromolecules

388

225

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Exopolysaccharides (EPS) are extracellular macromolecules excreted as tightly bound capsule or loosely attached slime layer in microorganisms. They play most prominent role against desiccation, phagocytosis, cell recognition, phage attack, antibiotics or toxic compounds and osmotic stress. In the last few decades, natural polymers have gained much attention among scientific communities owing to their therapeutic potential. In particular the EPS retrieved from probiotic bacteria with varied carbohydrate compositions possess a plenty of beneficial properties. Different probiotic microbes have unique behavior in expressing their capability to display significant health promoting characteristics in the form of polysaccharides. In this new era of alternative medicines, these polysaccharides are considered as substitutes for synthetic drugs. The EPS finds applications in various fields like textiles, cosmetics, bioremediation, food and therapeutics. The present review is focused on sources, chemical composition, biosynthetic pathways of EPS and their biological potential. More attention has been given to the scientific investigations on antimicrobial, antitumor, anti-biofilm, antiviral, anti-inflammatory and immunomodulatory activities.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Exopolysaccharides from probiotic bacteria and their health potential

Angelin

Kavitha

2020

International Journal of Biological Macromolecules

388

225

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“…The exopolysaccharides produced by Le. mesenteroides isolated from Korean Kimchi exhibited anti-inflammatory effects in LPS-stimulated RAW264.7 cells [42]. Ll.…”

Section: Cytokines Production In Cona-stimulated Splenocytes Isolated From Mouse Treated For 10 Days With Lcvmentioning

confidence: 97%

“…plantarum JLAU103 promoted the release of NO, TNF-α, and IL-6 in RAW264.7 macrophages and EPS103 reduced excessive release of NO, TNF-α, and IL-6 in LPS-stimulated RAW264.7 cells [43]. Although there are no research reports describing the effects of ECVs on inflammation, results demonstrating isolated from Korean Kimchi exhibited anti-inflammatory effects in LPS-stimulated RAW264.7 cells [42]. Ll.…”

Section: Cytokines Production In Cona-stimulated Splenocytes Isolated From Mouse Treated For 10 Days With Lcvmentioning

confidence: 99%

Immunomodulatory Activity of Extracellular Vesicles of Kimchi-Derived Lactic Acid Bacteria (Leuconostoc mesenteroides, Latilactobacillus curvatus, and Lactiplantibacillus plantarum)

Kim

Lee

Kim

et al. 2022

Foods

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Lactic acid bacteria present in Kimchi, such as Leuconostoc mesenteroides (Lm), Latilactobacillus curvatus (Lc), and Lactiplantibacillus plantarum (Lp) produce extracellular vesicles (ECVs) that modulate immune responses. The ECVs of probiotic Kimchi bacteria are abbreviated as LmV, LcV, and LpV. Treatment of macrophages (RAW264.7) with ECVs (LmV, LcV, and LpV) increased the production of nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin-6 (IL-6). Immunostimulatory effects exerted on the RAW264.7 cells were stronger after treatments with LmV and LcV than with LpV. Treatment of mice with LcV (1 mg/kg, orally) induced splenocyte proliferation and subsequent production of both NO and cytokines (INF-γ, TNF-α, IL-4, and IL-10). Furthermore, pre-treatment of macrophages and microglial cells with ECVs prior to LPS stimulation significantly attenuated the production of NO and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). Therefore, ECVs (LmV, LcV, and LpV) prevent inflammatory responses in the LPS-stimulated microglial cells by blocking the extracellular signal-regulated kinase (Erk) and p38 signaling pathways. These results showed that LmV, LcV, and LpV from Kimchi probiotic bacteria safely exert immunomodulatory effects.

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“…Oral administration of the EPS into mice reduced the duration of diarrhea, viral shedding, and destruction of enteric epithelium integrity in infected mice [ 96 ]. L. mesenteroides BioE-LMD18, an isolate from kimchi, produced an EPS of 123.8 kDa in size, which showed immunomodulatory effects in RAW 264.7 murine macrophage cells previously treated with lipopolysaccharide (LPS) from Escherichia coli [ 97 ]. EPS treatment reduced the amount of IL-6, a pro-inflammatory cytokine, by 32.1%, but increased the amount of IL-10, an anti-inflammatory cytokine, by a dose-dependent manner in LPS-treated cells.…”

Section: Important Metabolites Produced By Kimchi Labmentioning

confidence: 99%

Some Important Metabolites Produced by Lactic Acid Bacteria Originated from Kimchi

Lee

Yoo

Kim

2021

Foods

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Lactic acid bacteria (LAB) have been used for various food fermentations for thousands of years. Recently, LAB are receiving increased attention due to their great potential as probiotics for man and animals, and also as cell factories for producing enzymes, antibodies, vitamins, exopolysaccharides, and various feedstocks. LAB are safe organisms with GRAS (generally recognized as safe) status and possess relatively simple metabolic pathways easily subjected to modifications. However, relatively few studies have been carried out on LAB inhabiting plants compared to dairy LAB. Kimchi is a Korean traditional fermented vegetable, and its fermentation is carried out by LAB inhabiting plant raw materials of kimchi. Kimchi represents a model food with low pH and is fermented at low temperatures and in anaerobic environments. LAB have been adjusting to kimchi environments, and produce various metabolites such as bacteriocins, γ-aminobutyric acid, ornithine, exopolysaccharides, mannitol, etc. as products of metabolic efforts to adjust to the environments. The metabolites also contribute to the known health-promoting effects of kimchi. Due to the recent progress in multi-omics technologies, identification of genes and gene products responsible for the synthesis of functional metabolites becomes easier than before. With the aid of tools of metabolic engineering and synthetic biology, it can be envisioned that LAB strains producing valuable metabolites in large quantities will be constructed and used as starters for foods and probiotics for improving human health. Such LAB strains can also be useful as production hosts for value-added products for food, feed, and pharmaceutical industries. In this review, recent findings on the selected metabolites produced by kimchi LAB are discussed, and the potentials of metabolites will be mentioned.

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Immunomodulatory effects of exopolysaccharides produced by Bacillus licheniformis and Leuconostoc mesenteroides isolated from Korean kimchi

Cited by 47 publications

References 43 publications

Exopolysaccharides from probiotic bacteria and their health potential

Exopolysaccharides from probiotic bacteria and their health potential

Immunomodulatory Activity of Extracellular Vesicles of Kimchi-Derived Lactic Acid Bacteria (Leuconostoc mesenteroides, Latilactobacillus curvatus, and Lactiplantibacillus plantarum)

Some Important Metabolites Produced by Lactic Acid Bacteria Originated from Kimchi

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