Immunomodulatory effects of four polysaccharides purified from Erythronium sibiricum bulb on macrophages

Molecular Insights into the Macrophage Immunomodulatory Effects of Scrophulariae Radix Polysaccharides

“…The immunomodulatory activities of polysaccharides were closely related to their structural features including molecular weight, monosaccharide composition, conformation and glycosidic linkage [44–46] . Chen and colleagues purified four polysaccharides with different molecular weight and monosaccharide component from Erythronium sibiricum bulbs, and confirmed that all of them were able to dramatically promote the proliferation, neutral red phagocytosis and inflammatory factor secretion of macrophages [47] . Five polysaccharides from Angelica sinensis were compared for their structures and immunoregulative activities, indicating CAPS 70 possessed the strongest immuno‐enhancement activity [48] .…”

“…[44][45][46] Chen and colleagues purified four polysaccharides with different molecular weight and monosaccharide component from Erythronium sibiricum bulbs, and confirmed that all of them were able to dramatically promote the proliferation, neutral red phagocytosis and inflammatory factor secretion of macrophages. [47] Five polysaccharides from Angelica sinensis were compared for their structures and immunoregulative activities, indicating CAPS 70 possessed the strongest immuno-enhancement activity. [48] Therefore, the different immunomodulatory activities of SRPs observed in the present study might be associated with their diverse structures as evidenced by the absorption peaks and monosaccharide compositions.…”

Beyond cellulose: pharmaceutical potential for bioactive plant polysaccharides in treating disease and gut dysbiosis

“…Polysaccharides, formed by α - or β -glycosidic bond of identical or various monosaccharide monomers with10 or more polymerization, are naturally produced in large quantities by plants and fungi ( Tan et al, 2017 ). To date, numerous polysaccharides have been shown to exhibit a range of biological activities, including anticoagulation, antiviral, antitumor, antioxidant, hypoglycemic, and immunomodulatory effects ( Zeng et al, 2019 ; Zhang et al, 2019 ; Wang et al, 2019b ; Kalinina et al, 2020 ; Chaisuwan et al, 2021 ; Chen C. et al, 2021 ; Kiddane and Kim, 2021 ; Liang Q. et al, 2021 ; Surayot et al, 2021 ; Figure 1 and Table 1 ). In addition, many studies have proposed that some polysaccharides also contribute to shaping the structure, diversity and function of gut microbiota and thus play a role in enhancing human health ( Koropatkin et al, 2012 ; Chang et al, 2015 ; Lin et al, 2018 ; Zhang L. et al, 2018 ; Zhang X. et al, 2018 ; Chen G. et al, 2019 ; Ding et al, 2019 ; Wang M. et al, 2019 ; Wang Y. et al, 2020 ; Wang et al, 2020b ; Guo et al, 2021a ).…”