Immunomodulatory Effects of Green Tea Polyphenols

Wang, Shuzhen; Li, Zhiliang; Ma, Yuting; Liu, Yan; Lin, Chi-Chen; Li, Shiming; Zhan, Jianfeng; Ho, Chi‐Tang

doi:10.3390/molecules26123755

Cited by 75 publications

(47 citation statements)

References 116 publications

(202 reference statements)

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“…TP, especially EGCG and ECG, can significantly enhance the immune response and reduce the risk of inflammation and immune-related diseases [ 85 , 86 ]. As a natural immunomodulator, TP can deal with immune system diseases by up-regulating or down-regulating the immune response without adverse effects such as pro-inflammatory responses [ 87 ]. In the human body, T helper cell (Th)1 and Th2 are important members of cellular immunity and humoral immunity, respectively.…”

Section: Immunomodulatory Effects Of Tp-mediated Gut-lung Axis On Cov...mentioning

confidence: 99%

“…In addition to antiviral therapy, anti-inflammatory therapy that suppresses cytokine storm is essential to reduce mortality in patients with COVID-19. IL-6 is often elevated in patients with COVID-19, and its level is positively correlated with COVID-19 mortality [ 87 , 99 ]. Persistent cytokine storm increases the alveolar vascular permeability, the body fluid and blood cells enter the alveoli, resulting in pulmonary edema, ARDS, and even respiratory failure [ 100 , 101 ].…”

Section: Immunomodulatory Effects Of Tp-mediated Gut-lung Axis On Cov...mentioning

confidence: 99%

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A Natural Plant Source-Tea Polyphenols, a Potential Drug for Improving Immunity and Combating Virus

Hong

Liu

et al. 2022

Nutrients

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The coronavirus disease 2019 (COVID-19) is still in a global epidemic, which has profoundly affected people’s lives. Tea polyphenols (TP) has been reported to enhance the immunity of the body to COVID-19 and other viral infectious diseases. The inhibitory effect of TP on COVID-19 may be achieved through a series of mechanisms, including the inhibition of multiple viral targets, the blocking of cellular receptors, and the activation of transcription factors. Emerging evidence shows gastrointestinal tract is closely related to respiratory tract, therefore, the relationship between the state of the gut–lung axis microflora and immune homeostasis of the host needs further research. This article summarized that TP can improve the disorder of flora, reduce the occurrence of cytokine storm, improve immunity, and prevent COVID-19 infection. TP may be regarded as a potential and valuable source for the design of new antiviral drugs with high efficiency and low toxicity.

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Section: Immunomodulatory Effects Of Tp-mediated Gut-lung Axis On Cov...mentioning

confidence: 99%

Section: Immunomodulatory Effects Of Tp-mediated Gut-lung Axis On Cov...mentioning

confidence: 99%

A Natural Plant Source-Tea Polyphenols, a Potential Drug for Improving Immunity and Combating Virus

Hong

Liu

et al. 2022

Nutrients

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“…These findings imply that pretreatment with the J. effusus L. water extract reduces the innate immune response by blocking the binding sites on oral epithelial cells for TLR2 and TLR4 ligands, suggesting that the J. effusus L. water extract may be beneficial in the prevention of innate immune responses that leads to periodontal tissue inflammation. It has been reported that EGCG inhibits intracellular signal transduction pathways and ultimately suppresses the transcription of various inflammation-related mediators [ 44 – 46 ]. This study indicated that pretreatment with J. effusus L. water crude extract suppressed the expression and production of chemokine genes by inhibiting the binding of TLR ligands.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes

Wada

Murakami

Ishikawa

et al. 2022

BioMed Research International

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Periodontitis is a chronic inflammatory disease caused by periodontopathogenic bacteria that form biofilms in periodontal pockets. The gingival epithelium acts as the first physical barrier in fighting attacks by periodontopathogenic pathogens, such as the primary etiological agent Porphyromonas gingivalis, and various exogenous chemicals, as well as regulates the local innate immune responses. Therefore, the development of novel oral care products to inhibit inflammatory reactions caused by bacterial infection and protect the gingival epithelium is necessary. Juncus effusus L. has generally been used as an indigenous medicine, such as a diuretic, an antipyretic, and an analgesic, in ancient practice. In this study, we examined the effects of a water extract from J. effusus L. on the inhibition of the inflammatory reaction elicited by bacterial infection and protection of the oral epithelium by chemical irritation. Pretreatment of oral epithelial cells with the water extract from J. effusus L. significantly reduced P. gingivalis or its lipopolysaccharide- (LPS-) mediated production of chemokines (interleukin-8 and C-C-chemokine ligand20) in a concentration-dependent manner with comparable to or greater effects than epigallocatechin gallate and protected oral epithelial cells from injury by chemical irritants, cetylpyridinium chloride, and benzethonium chloride. Moreover, the water extract from J. effusus L. in the presence of antimicrobial agents or antifibrinolytics already used as ingredients in mouthwash could significantly reduce the production of chemokines from P. gingivalis LPS-stimulated oral epithelial cells in a concentration-dependent manner. These findings suggest that the water extract from J. effusus L. is potentially useful for oral care to prevent oral infections, such as periodontal infections, and maintain oral epithelial function.

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“…Hence, factors that limit the activation of NF-κB may also prevent the expression of cytokines, and consequently block inflammatory response. EGCG inhibits the activation of NF-κB and MAPK as well as the expression of IFNγ, TNF-α, and IL-1β, while also stimulating the innate expression of immunity-related genes (e.g., TNF-α, MAPK, NOS) and inhibiting apoptosis [135]. EGCG may also inhibit the infiltration of inflammatory and pro-inflammatory leukocytes IL-8, while studies on mice revealed that it can lower the expression of pro-inflammatory factors: NF-κB and IL-6 [135][136][137].…”

Section: Anti-inflammatory and Immunomodulatory Propertiesmentioning

confidence: 99%

“…EGCG inhibits the activation of NF-κB and MAPK as well as the expression of IFNγ, TNF-α, and IL-1β, while also stimulating the innate expression of immunity-related genes (e.g., TNF-α, MAPK, NOS) and inhibiting apoptosis [135]. EGCG may also inhibit the infiltration of inflammatory and pro-inflammatory leukocytes IL-8, while studies on mice revealed that it can lower the expression of pro-inflammatory factors: NF-κB and IL-6 [135][136][137]. Thichanpiang and Wongprasert [118] demonstrated that EGCG shows anti-inflammatory effects on human retinal pigmented epithelial cells ARPE-19, partially as a suppressor of TNF-α signaling, and that the inhibitive effects occur along the NF-κB pathway.…”

Section: Anti-inflammatory and Immunomodulatory Propertiesmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

2021

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The physiological markers of autoimmune diabetes include functional disorders of the antioxidative system as well as progressing inflammation and the presence of autoantibodies. Even though people with type 1 diabetes show genetic predispositions facilitating the onset of the disease, it is believed that dietary factors can stimulate the initiation and progression of the disease. This paper analyses the possibility of using tea as an element of diet therapy in the treatment of type 1 diabetes. Based on information available in literature covering the last 10 years, the impact of regular tea consumption or diet supplements containing tea polyphenols on the oxidative status as well as inflammatory and autoimmune response of the organism was analyzed. Studies conducted on laboratory animals, human patients, and in vitro revealed positive effects of the consumption of tea or polyphenols isolated therefrom on the diabetic body. Few reports available in the literature pertain to the impact of tea on organisms affected by type 1 diabetes as most (over 85%) have focused on cases of type 2 diabetes. It has been concluded that by introducing tea into the diet, it is possible to alleviate some of the consequences of oxidative stress and inflammation, thus limiting their destructive impact on the patients’ organisms, consequently improving their quality of life, regardless of the type of diabetes. Furthermore, elimination of inflammation should reduce the incidence of immune response. One should consider more widespread promotion of tea consumption by individuals genetically predisposed to diabetes, especially considering the drink’s low price, easy availability, overall benefits to human health, and above all, the fact that it can be safely used over extended periods of time, regardless of the patient’s age.

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Immunomodulatory Effects of Green Tea Polyphenols

Cited by 75 publications

References 116 publications

A Natural Plant Source-Tea Polyphenols, a Potential Drug for Improving Immunity and Combating Virus

A Natural Plant Source-Tea Polyphenols, a Potential Drug for Improving Immunity and Combating Virus

Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes

Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of Tea—The Positive Impact of Tea Consumption on Patients with Autoimmune Diabetes

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