Immunomodulatory effects of<i>Echinacea</i>and<i>Pelargonium</i>on the innate and adoptive immunity in calves

Seckin, Cuneyt; Kalayci, Gamze Alpun; Turan, Nuri; Yilmaz, Aysun; Cizmecigil, Utku Y.; Aydın, Özge; Richt, Jüergen A.; Yılmaz, Hüseyin

doi:10.1080/09540105.2018.1444738

Cited by 26 publications

(9 citation statements)

References 65 publications

(96 reference statements)

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“…This can be explained by the negative feedback regulating mechanism among cytokines (Dambuza et al, 2017). In addition, we observed significantly higher serum concentrations of TGF-β1, TNF-α, IFN-γ and GM-CSF in FP than the control group, possibly because the increased concentrations of TNF-α, IFN-γ and GM-CSF promoted the production of TGF-β1, while TGF-β1 inhibited the production of TNF-α, IFN-γ and GM-CSF (Seckin, Kalayci, Turan, Yilmaz, & Yilmaz, 2018;Zhao et al, 2020). The down-regulated cytokines showing immunosuppression were observed in the PGR piglets and IUGR piglet neonates (Qi et al, 2019b ;Dong et al, 2014), but supplementation with functional bioactive substances could regulate the activity of serum cytokines and stimulate the immune function of growth retardation piglets.…”

Section: Discussionmentioning

confidence: 70%

Functional bioactive substance improves the growth performance, antioxidant capacity and immune function of growth retardation pigs

Wang

Tan

Liao

et al. 2020

Food and Agricultural Immunology

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This study was conducted to investigate the effects of composited functional bioactive substances on the growth performance and immune function of growth retardation (GR) pigs. Twenty-four 42day-old GR pigs were fed with basal diet containing 0 or 0.5% composited functional bioactive substances package (FP) for 21 days. The results showed that dietary supplementation with FP decreased feed:gain ratio, increased the relative and absolute weight of the liver (P < 0.05). Supplementation with FP decreased serum alkaline phosphatase and malondialdehyde, but increased aspartic acid, cysteine, arginine, proline and taurine concentrations, as well as serum superoxide dismutase and catalase activities (p < 0.05). FP treatment increased all determined cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12, GM-CSF, IFN-γ, TGF-β1, TNF-α) concentrations in serum compared with the control treatment (p < 0.05). These findings indicate that functional bioactive substances can improve feed conversion rate, serum anti-oxidant capacity and immunity and can be as effective growth promoter in the GR piglets.

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Section: Discussionmentioning

confidence: 70%

Functional bioactive substance improves the growth performance, antioxidant capacity and immune function of growth retardation pigs

Wang

Tan

Liao

et al. 2020

Food and Agricultural Immunology

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“…The antibacterial activity has been associated with macrophage activation determined through TNF-α and inorganic nitric oxide in macrophage cultures (Kayser et al, 2001). Additionally, P. sidoides has been used in a tablet with Echinacea purpurae increasing IgG and IFN-γ, as well as certain cytokine gene expressions, modulating immune response (Seckin et al, 2018).…”

Section: Immune-enhancing Propertiesmentioning

confidence: 99%

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

Garnier¹,

Shahidi²

2021

Journal of Food Bioactives

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Spices and herbs have been used in traditional medicine for centuries, with research starting to accumulate on their beneficial properties. Of these properties, the immune-enhancing and anti-inflammatory capabilities of many spices and herbs have led to promising results. The current review article aims to explore the current research of several spices and herbs as immune-enhancers and anti-inflammatory agents. The spices and herbs examined are African potato (Hypoxis hemerocallidea), allspice (Pimenta dioica), basil (Ocimum basilicum), black pepper (Piper nigrum), chili powders (Capsicum species), clove (Syzygium aromaticum), Devil’s claw (Harpagophytem procumbens), fenugreek (Trigonella foenum-graecum), ginger (Zingiber officinale), lavender (Lavandula angustifolia), oregano (Origanum vulgare), rooibos (Aspalathus linearis), rosemary/sage (Salvia rosmarinus/officinalis), saffron (Crocus sativus), South African geranium (Pelargonium sidoides), and turmeric (Curcuma longa). All the spices and herbs exhibited immune-enhancing or immunomodulatory and anti-inflammatory capabilities through various processes. Rooibos and oregano had the most contradictory results, with some studies finding pro-inflammatory properties, especially at high doses regarding oregano. Turmeric had the most extensive research with positive results.

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“…Polysaccharides, alkylamides, caffeic acid esters, and polyacetylenes are the main compounds contained in Echinacea Moench [Barnes et al 2005]. An in vivo study [Seckin et al 2018] has demonstrated improved immune response in calves receiving a medicinal preparation based on Echinacea purpurea (L.) Moench and Pelargonium sidoides DC.…”

Section: Potential Use Of Phytobiotics For Treatment and Prophylaxis mentioning

confidence: 99%

Biologically active compounds of plant origin in medicine

Chwil¹,

Skoczylas²

2021

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Immunomodulatory effects ofEchinaceaandPelargoniumon the innate and adoptive immunity in calves

Cited by 26 publications

References 65 publications

Functional bioactive substance improves the growth performance, antioxidant capacity and immune function of growth retardation pigs

Functional bioactive substance improves the growth performance, antioxidant capacity and immune function of growth retardation pigs

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

Biologically active compounds of plant origin in medicine

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