Immunomodulatory effects of metal salts at sub‐toxic concentrations

Steinborn, Carmen; Diegel, Christoph; Garcia-Käufer, Manuel; Gründemann, Carsten; Huber, Roman

doi:10.1002/jat.3390

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…At present, the effect of arsenic on it is currently controversial. Although most studies believe that arsenic has immunosuppressive effects [ 24 – 26 ], there are also studies that suggest arsenic could be used as an immune stimulant to induce allergic reactions and autoimmune diseases [ 5 , 27 – 29 ]. Immune regulation is necessary to control the occurrence and development of inflammation and autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen

Yan

Zhang

et al. 2020

Cell Biosci

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Background Arsenic exposure has become a matter of worldwide concern, which is associated with immune-related diseases. However, little is known about its effect on inflammatory immune-related homeostasis. The purpose of our study was to understand the potential tuning of above responses exerted by chronic arsenic exposure. Methods Kunming mice were treated with 25 and 50 mg/L sodium arsenite for 1, 3 and 12 months via drinking water. At different endpoints of arsenic exposure, all animals and the whole spleen of the mice were weighed. The total arsenic levels of spleen were determined by the HPLC-HG-AFS method. Splenic NF-κB, MAPK and NRF2 protein levels by treatment of 25 mg/L NaAsO 2 for 1, 3 and 12 months and 25 mg/L and 50 mg/L NaAsO 2 for 12 months were assessed by western blot. Total RNA of spleen was isolated and relative mRNA levels of Foxp3 , Il - 10 , Tnf - α , Il - 6 , Ifn - γ , Il - 1β and Il - 12 were measured by real-time PCR. Results Our results shown that NF-κB were continuously activated with treatment of 25 mg/L arsenic from 1, 3 to 12 months and 50 mg/L arsenic for 12 months. The transcription factor Foxp3 increased at 1 month but decreased at 3 and 12 months no matter 25 or 50 mg/L arsenic exposure. However, cytokine Il - 10 always showed increased trend in mice treated with 25 or 50 mg/L arsenic for 1, 3 and 12 months. The transcriptional profiles of Tnf - α , Il - 1β , Il - 6 , Ifn - γ and Il - 12 revealed transient elevation at 1 and 3 months but shown significant decrease at 12 months on the whole. In addition, the sustained activation of inflammatory MAPK and anti-oxidative Nrf2 signaling pathways were observed in mice exposed to arsenic for 1, 3 and 12 months. Conclusion In summary, our experiment in vivo suggested chronic arsenic exposure induces the time-dependent modulation of the inflammation and immunosuppression in spleen, which may be related to the activation of Tregs induced by MAPK/NF-κB as well as the increased transcription level of Foxp3 and Il - 10 .

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Section: Discussionmentioning

confidence: 99%

Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen

Yan

Zhang

et al. 2020

Cell Biosci

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“…On the contrary, excessive Cu-fortification of LF might lead to decreased anti-inflammatory activity in the stimulated macrophages. Although Cu is very important to the immune system, it was also found that higher Cu levels led to an immuno-suppressive effect on the primary human mononuclear cells ( Steinborn et al, 2017 ). It is thus reasonable that LF-Cu-20 had lower anti-inflammatory activity than LF-Cu-10 in the stimulated cells.…”

Section: Discussionmentioning

confidence: 99%

Low-level Cu-fortification of bovine lactoferrin: Focus on its effect on in vitro anti-inflammatory activity in LPS-stimulated macrophages

Zhang,

Zhao,

Huang

et al. 2023

Current Research in Food Science

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“…The immunoregulatory effect of intracellular copper metabolism has been examined in several studies (Videla et al, 2003;Steinborn et al, 2017;Zhao and Zhao, 2019). Deigendesch et al (2018) found that depriving intracellular copper transporters of copper ions inhibited inflammasome activation in macrophages, thereby regulating the immune phenotype of macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…Low-concentration copper preparations have been reported to have promising immunomodulatory potential and to contribute to oxidative stress in macrophages (Videla et al, 2003;Steinborn et al, 2017;Zhao and Zhao, 2019). Mitochondrial-derived reactive oxygen species (mtROS) are believed to derive mainly from NADH dehydrogenase when there is a high NADH/NAD+ ratio in the mitochondrial matrix.…”

Section: High Levels Of Mitochondrial-derived Reactive Oxygen Species Might Enhance Ccm-promoted Expression Of Pdgf-bb By M2a Macrophagesmentioning

confidence: 99%

Copper-Containing Alloy as Immunoregulatory Material in Bone Regeneration via Mitochondrial Oxidative Stress

Qian

Guan

et al. 2021

Front. Bioeng. Biotechnol.

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In the mammalian skeletal system, osteogenesis and angiogenesis are closely linked by type H vessels during bone regeneration and repair. Our previous studies confirmed the promotion of these processes by copper-containing metal (CCM) in vitro and in vivo. However, whether and how the coupling of angiogenesis and osteogenesis participates in the promotion of bone regeneration by CCM in vivo is unknown. In this study, M2a macrophages but not M2c macrophages were shown to be immunoregulated by CCM. A CCM, 316L−5Cu, was applied to drilling hole injuries of the tibia of C57/6 mice for comparison. We observed advanced formation of cortical bone and type H vessels beneath the new bone in the 316L−5Cu group 14 and 21 days postinjury. Moreover, the recruitment of CD206-positive M2a macrophages, which are regarded as the primary source of platelet-derived growth factor type BB (PDGF-BB), was significantly promoted at the injury site at days 14 and 21. Under the stimulation of CCM, mitochondria-derived reactive oxygen species were also found to be upregulated in CD206hi M2a macrophages in vitro, and this upregulation was correlated with the expression of PDGF-BB. In conclusion, our results indicate that CCM promotes the evolution of callus through the generation of type H vessels during the process of bone repair by upregulating the expression of PDGF-BB derived from M2a macrophages.

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Immunomodulatory effects of metal salts at sub‐toxic concentrations

Cited by 8 publications

References 41 publications

Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen

Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen

Low-level Cu-fortification of bovine lactoferrin: Focus on its effect on in vitro anti-inflammatory activity in LPS-stimulated macrophages

Copper-Containing Alloy as Immunoregulatory Material in Bone Regeneration via Mitochondrial Oxidative Stress

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