Immunomodulatory effects of mixed <i>Lactobacillus plantarum</i> on lipopolysaccharide-induced intestinal injury in mice

Dong, Jiahuan; Ping, Lijun; Zhang, Kangyong; Tang, Hongwei; Liu, Jie; Liu, Deyu; Zhao, Li; Evivie, Smith Etareri; Li, Bailiang; Gui-cheng, Huo

doi:10.1039/d1fo04204a

Cited by 10 publications

(5 citation statements)

References 66 publications

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“…37 TLR4, a membrane receptor, is responsible for LPS recognition and signal initiation. 38 NF-κB is a key molecule in the TLR4 signaling pathway, which regulates the expression of pro-inflammatory cytokines and induces inflammatory damage. 39 CUR is regarded as an activator of Nrf2, which plays an important role in inhibiting LPS-induced NF-κB activation and microglial activation caused by LPS.…”

Section: Discussionmentioning

confidence: 89%

“…The antioxidant effects of HO‐1 are mainly mediated by metabolites of the heme group, including bilirubin, biliverdin, carbon monoxide (CO), and free iron 37 . TLR4, a membrane receptor, is responsible for LPS recognition and signal initiation 38 . NF‐κB is a key molecule in the TLR4 signaling pathway, which regulates the expression of pro‐inflammatory cytokines and induces inflammatory damage 39 .…”

Section: Discussionmentioning

confidence: 99%

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Curcumin: a potential exogenous additive for the prevention of LPS‐induced duck ileitis by the alleviation of inflammation and oxidative stress

Yang

Yin

et al. 2022

J Sci Food Agric

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BACKGROUND Lipopolysaccharides (LPS) are the main pathogenic substances in Gram‐negative bacteria. The aim of this study was to investigate the preventive effects of dietary curcumin (CUR) on LPS toxicity in the duck ileum. The duck diet was supplemented with CUR (0.5 g kg−1) for 28 days, while the birds were injected with LPS (0.5 mg kg−1 body weight per injection, administered as seven injections in the last week of the experimental period). RESULTS LPS significantly decreased the ileal villus‐to‐crypt ratio in the non‐supplemented CUR group. Dietary CUR alleviated LPS‐induced morphological damage to the ileum. Moreover, dietary CUR alleviated oxidative stress by increasing the levels of total superoxide dismutase (T‐SOD) (P < 0.05) and glutathione S‐transferase (GST) (P < 0.05) and decreasing the production of malonic dialdehyde (MDA) (P < 0.05) in control ducks and LPS‐challenged ducks. Dietary CUR significantly inhibited the LPS‐induced massive production of inflammatory factors (IL‐1β, IL‐6, and TNF‐α) (P < 0.05). CUR induced the inhibition of TLR4 and activation of Nrf2 to reduce the expression of inflammation‐related genes (TLR4, NF‐κB, IKK, TXNIP, NLRP3, caspase‐1, IL‐1β, IL‐6, and TNF‐α). Moreover, dietary CUR ameliorated the decrease in claudin‐1 and occludin expression (P < 0.05) and improved ZO‐1 expression in the duck ileum (P < 0.05). CONCLUSION In conclusion, dietary CUR has beneficial effects on LPS‐induced ileal damage, oxidative damage, and inflammatory response by inhibiting the TLR/NF‐κB and activating the Nrf2 signaling pathways in ducks. This study provides valuable information regarding the therapeutic uses of CUR in duck ileitis. © 2022 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Curcumin: a potential exogenous additive for the prevention of LPS‐induced duck ileitis by the alleviation of inflammation and oxidative stress

Yang

Yin

et al. 2022

J Sci Food Agric

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“…However, it has also been shown that D. vulgaris from the genus Desulfovibrio is an effective producer of acetic acid, which may be effective in reducing hepatic steatosis in mice by producing acetic acid and regulating hepatic lipid metabolism ( Hong et al, 2021 ). In addition, some probiotics or prebiotics could also significantly enhance the abundance of Desulfovibrio in mice ( Cui et al, 2022 ; Dong et al, 2022 ). Our results suggest that Desulfovibrio may play a beneficial role in the alleviation of FC by MOAE, as Desulfovibrio was significantly positively correlated with GTR and intestinal barrier factors and negatively correlated with FBST, gastrointestinal motility factors, and short-chain fatty acid content.…”

Section: Discussionmentioning

confidence: 99%

Moringa oleifera leaf alleviates functional constipation via regulating the gut microbiota and the enteric nervous system in mice

Gao,

Yang,

et al. 2023

Front. Microbiol.

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Moringa oleifera Lam. leaf is not only a new food resource in China, but also a traditional medicinal plant. It is commonly used in the folk to alleviate constipation, but its laxative mechanism is not fully understood. Hence we investigated it in loperamide-induced functional constipation (FC) mice. The results showed that MOAE significantly regulated not only gastrointestinal hormones and neurotransmitters in serum but also important gastrointestinal motility factors in the enteric nervous system (ENS)-interstitial cells of Cajal (ICCs)-smooth muscle cell (SMC) network. Meanwhile, MOAE attenuated intestinal inflammation, increased cecal short-chain fatty acid levels and colonic antimicrobial peptide expression, and improved the impaired intestinal barrier function in loperamide-induced FC mice. In addition, MOAE also increased fecal water content by inhibiting the mRNA expression of colonic aquaporins (Aqp3 and Aqp4) in FC mice. Interestingly and importantly, MOAE affected the intestinal microbiota by inhibiting some key “constipation-causing” microbiota, such as Bacteroidaceae, Clostridiaceae, Bacteroides, and Ruminococcus, and promoting the growth of other important “constipation-curing” microbiota, such as Butyricoccus, Tyzzerella, and Desulfovibrio. These important taxa are significantly associated with a variety of indicators of constipation. These findings suggest that MOAE can promote defecation through its rich chemical composition to modulate the ENS-ICCs-SMCs network and the gut microecosystem.

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“…[12]. In experimental models of metabolic disease, Lactobacillus plantarum has been shown to have potential therapeutic effects on various conditions [13,14], such as improving hypertension [15], hypercholesterolemia [16], immunomodulation [17,18] and promoting fat loss and weight loss [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

The Probiotic Kluyveromyces lactis JSA 18 Alleviates Obesity and Hyperlipidemia in High-Fat Diet C57BL/6J Mice

Hong,

Song,

Feng

et al. 2024

Foods

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Obesity poses a significant threat to various health conditions such as heart diseases, diabetes, high blood pressure, and heart attack, with the gut microbiota playing a crucial role in maintaining the body’s energy balance. We identified a novel probiotic fungal strain, Kluyveromyces lactis JSA 18 (K. lactis), which was isolated from yak milk and was found to possess anti-obesity properties. Additionally, Lactobacillus plantarum CGMCC 8198 (LP8198) from our previous study was also included to evaluate its anti-obesity properties. The findings indicated that K. lactis caused a notable reduction in weight gain, liver and fat indexes, and hyperlipidemia in mice fed a high-fat diet (HFD). Administering K. lactis and LP8198 to mice on a high-fat diet resulted in a reduction of serum triglyceride levels. Furthermore, the supplements reduced ALT and AST activity, and inhibited the production of inflammatory cytokines such as TNF-α and IL-1β. In addition, lipid metabolism was enhanced by the downregulation of ACC1, PPAR-γ, SREBP-1, and Fasn. Moreover, this study found that K. lactis and LP8198 have little effect on gut bacteria. Additionally, K. lactis partially influenced intestinal fungi, while LP8198 had a minor influence on gut mycobiota. The main goal of this research was to show how effective K. lactis can be as a probiotic in combating obesity.

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Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide-induced intestinal injury in mice

Abstract: Intestine is the largest digestive and immune organ in the human body with an intact intestinal mucosal barrier. Lactobacillus plantarum is an important strain of probiotics in the intestine for...

Cited by 10 publications

References 66 publications

Curcumin: a potential exogenous additive for the prevention of LPS‐induced duck ileitis by the alleviation of inflammation and oxidative stress

Curcumin: a potential exogenous additive for the prevention of LPS‐induced duck ileitis by the alleviation of inflammation and oxidative stress

Moringa oleifera leaf alleviates functional constipation via regulating the gut microbiota and the enteric nervous system in mice

The Probiotic Kluyveromyces lactis JSA 18 Alleviates Obesity and Hyperlipidemia in High-Fat Diet C57BL/6J Mice

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