Immunomodulatory effects of neem (Azadirachta indica) oil

Upadhyay, Swati; Dhawan, Suman; Garg, Sanjay; Talwar, G. P.

doi:10.1016/0192-0561(92)90054-o

Cited by 99 publications

(61 citation statements)

References 6 publications

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“…Moreover we have earlier reported that TAM contributes directly to the promotion of DL growth (Parajuli and Singh, 1996). The difference of these observations from that of Upadhyay et al (1992) could be due to the fact that they used normal macrophages which are responsive for activation whereas in the present study we used TAM which we have demonstrated to be in a suppressed state and are unresponsive to activation signals (Parajuli et al, 1997). On the basis of the observations of the present study we suggest that crude neem oil contains some components, which help in progression of DL.…”

Section: Discussionmentioning

confidence: 40%

“…Neem oil has been shown to have a modulatory effect on the immune system (Upadhyay et al, 1992) and similar nature of immunostimulation was also seen with neem leaf extract (Ray et al, 1996) and neem derived polysaccharides (Fujiwara et al, 1982). Inspite of these findings the effect of neem oil on tumor growth remains neglected.…”

Section: Discussionmentioning

confidence: 93%

“…The activity of neem with the crude extracts, their different fractions and active components have been studied (Koul et al, 2004). Neem oil has been shown to possess immunomodulatory properites (Upadhyay et al, 1992) and polysaccharides isolated from neem bark have shown to inhibit the growth of sarcoma 180 (Fujiwara et al, 1982). However, it remains unclear if products derived from neem oil can also alter the growth of a T-cell lymphoma and related antitumor immunity.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Neem (Azadirachta indica) oil on the progressive growth of a spontaneous T cell lymphoma

Mallick¹,

Gupta²,

Singh³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe present study was undertaken to investigate the effect of in vivo administration of neem oil intra-peritoneally (i.p.) to mice bearing a progressively growing transplantable T cell lymphoma of spontaneous origin, designated as Daltons lymphoma (DL), on the tumor growth. Mice were administered various doses of neem oil mixed in groundnut oil, which was used as a diluting vehicle or for administration to control DL-bearing mice. Administration of neem oil resulted in an acceleration of tumor growth along with a reduction in the survival time of the tumor-bearing host. Neem oil administered DL-bearing mice showed an augmented apoptosis in splenocytes, bone marrow cells and thymocytes along with an inhibition in the anti-tumor functions of tumorassociated macrophages. Thus this study gives an altogether a novel information that neem oil instead of the popular belief of being anti-tumor and immunoaugmentary may in some tumorbearing conditions, behave in an opposite way leading to an accelarated tumor progression along with a collapse of the host's anti-tumor machinery. These observations will thus have long lasting clinical significance, suggesting caution in use of neem oil for treatment of cancer.

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Section: Discussionmentioning

confidence: 40%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Neem (Azadirachta indica) oil on the progressive growth of a spontaneous T cell lymphoma

Mallick¹,

Gupta²,

Singh³

et al. 2008

Oriental Pharmacy and Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…Pretreatment with the oil did not augment the anti-tetanus-toxin antibody response. The results of this study indicate that the oil acts as a nonspecific immunostimulant and that it selectively activates cell-mediated immune mechanisms to elicit an enhanced response to subsequent mitogenic or antigenic challenge [47] . Intraperitoneal administration of the oil to mice (150 µL/animal) and rats (120 µL/animal) enhanced phagocytosis of macrophages [47,48] .…”

Section: Immune Effectmentioning

confidence: 84%

“…The results of this study indicate that the oil acts as a nonspecific immunostimulant and that it selectively activates cell-mediated immune mechanisms to elicit an enhanced response to subsequent mitogenic or antigenic challenge [47] . Intraperitoneal administration of the oil to mice (150 µL/animal) and rats (120 µL/animal) enhanced phagocytosis of macrophages [47,48] . The oil obtained from A. indica plant had cytotoxic and proliferating activities; the oil significantly reduced the proliferating cell nuclear antigen levels in the cell and the apoptotic activity due to mitochondial pathway [49] .…”

Section: Immune Effectmentioning

confidence: 84%