Immunomodulatory effects of orally administrated florfenicol in rainbow trout (Oncorhynchus mykiss) following experimental challenge with streptococcosis/lactococcosis

Shiry, Nima; Soltanian, Siyavash; Shomali, Tahoora; Paknejad, Hamed; Hoseinifar, Seyed Hossein

doi:10.1016/j.intimp.2019.05.007

Cited by 21 publications

(9 citation statements)

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“…The ALP levels increased in a dose-dependent fashion with the highest in the 10X group on day 30 FFC-dosing. These results are in agreement with the observations recorded in sh during the misuse of FFC (Shiry et al 2020) and goat (Shah et al 2016) upon FFC injection. Although the ALP levels reduced with the cessation of FFC-dosing in all the treatment groups, their levels were still signi cantly higher than on day 0.…”

Section: Discussionsupporting

confidence: 92%

The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

Bardhan

Abraham

Singha

et al. 2022

Environ Sci Pollut Res

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Tilapia is one of the most consumed farmed sh, which requires the use of antibiotics in certain phases of its production. This study assessed the safety of 30 days of oral orfenicol (FFC)-dosing at 0-10 times the therapeutic dose (1X: 10 mg/kg biomass/day) in Oreochromis niloticus juveniles. Behavioural changes, feed consumption, mortality and biomass were evaluated. Besides, the levels of serum glucose, calcium, chloride, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and blood cell morphology were determined at scheduled intervals. The 30 days of oral FFC-dosing caused 3.33% (1X) to 18.33% (10X) mortalities, reduced feed intake and biomass in a dosedependent manner. The sh fed the therapeutic dose recorded 1.25 folds increase in biomass; while the control group recorded 1.45 folds increase in 30 days. No signi cant erythrocyte morphological alterations were observed in the 1X group compared to the control. However, marked morphological alterations like tear-shaped, spindle-shaped and degenerative erythrocytes in higher dosing groups indicated FFC cytotoxicity. All the serum biomarkers of O. niloticus increased signi cantly on day 10 and day 30 FFC-dosing in a dose-dependent manner, except for calcium and chloride, which reduced signi cantly during the dosing period. Within 2 weeks of suspension of FFC-dosing, the serum biomarker levels became normal except for alkaline phosphatase and creatinine. The recovery of biomass, feed intake, serum biomarker levels and erythrocyte morphological changes suggested that the FFC induced changes are reversible. This study has, thus, proclaimed the safety of FFC at the therapeutic dose in O. niloticus.

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Section: Discussionsupporting

confidence: 92%

The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

Bardhan

Abraham

Singha

et al. 2022

Environ Sci Pollut Res

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“…The biochemical examination is a vital and more important tool used to assess the nutritional, and health status, and the capability of fish for adaptation to the external environment (Abdel‐Tawwab, 2016; Burgos‐Aceves et al, 2019; Faggio et al, 2014; Fazio et al, 2013; Sehonova et al, 2018). Total protein as a general biomarker represents all protective enzymes, stress hormones and metabolites circulating vital fluid in the body; so, it is an important indicator of humoral defence system (Shiry et al, 2019). The present results found that TP, ALB and GLO values significantly ( p < .05) increased as BO levels in diets increased where their highest values were recorded in shrimp fed diets with 2.5–5.0 g BO/kg diet.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary sweet basil (Ocimum basilicum) oil on the performance, antioxidants and immunity welfare, and resistance of Indian shrimp (Penaeus indicus) againstVibrio parahaemolyticusinfection

Abdel‐Tawwab

El‐Ashram²,

Tahoun

et al. 2021

Aquacult Nutr

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In the present study, Indian shrimp, Penaeus indicus, were fed on diets supplemented with basil (Ocimum basilicum) oil (BO) to observe the growth performance, antioxidant and innate immune responses, and the resistance against Vibrio parahaemolyticus infection. The animals (5.0–5.5 g) were fed on diets supplemented with 0.0 (control), 1.0, 2.5 and 5 g BO/kg diet over 90 days. After the feeding trial, animals were intramuscularly injected by V. parahaemolyticus and observed for 96 h for mortality or any abnormal signs. Growth‐stimulating effects of dietary BO supplementation on final weight, weight gain percentage, specific growth rate and feed intake were observed. No significant differences were found in feed conversion ratio, protein efficiency ratio, protein productive value and animal survival. Feeding the animals on BO‐enriched diets did not significantly affect the chemical proximate composition of animals’ muscles. Increased values of total protein, albumin and globulin were observed in BO‐fed animals; meanwhile, aspartate and alanine aminotransferases as well as creatinine and urea levels significantly decreased in animals fed 2.5–5.0 g BO/kg diet. Activities of superoxide dismutase, catalase, glutathione peroxidase, lysozyme and phenol oxide activity significantly (p < .05) increased in the BO‐fed fish, with highest values in treatments of 2.5–5.0 g/kg diet. The dietary BO supplementation significantly (p < .05) decreased levels of malondialdehyde and nitrous oxide. After the bacterial challenge, 66.7 percent of animals in the control group were dead. The BO‐fed animals were more resistant against bacterial challenge especially at levels of 2.5–5.0 g/kg diet, which showed high relative percentage of survival (80.0–86.7 percent). In conclusion, dietary BO supplementation with levels of 2.5–5.0 g/kg diet proved beneficial effects to Indian shrimp where growth performance, antioxidant systems and innate immunity were stimulated. It also promoted the challenge of Indian shrimp against V. parahaemolyticus infection.

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“…In addition, only the group offered TTO‐supplemented diets at two‐week intervals had significantly high transcriptions levels of peroxiredoxin‐5 , which indicated that dietary administration of TTO in an appropriate feeding mode could efficiently reduce the inflammatory response in the intestinal tract of prawns by downregulating the transcription of intestinal proinflammatory factors but increasing the transcription of anti‐inflammatory genes. A possible explanation could be that both IL‐1 and TNF‐α can activate the NF‐κB pathway through the regulation of NO release, which is closely related to immunity and the anti‐inflammatory and anti‐oxidant capabilities of animals (Song, Guo, Wang, & Wang, 2014; Jangiam et al, 2015; Shiry, Soltanian, Shomali, & Paknejad, 2019). This possibility is supported by the knowledge that dorsal in prawn is highly homologous to the NF‐κB gene in mammals, while toll is the gene upstream of the NF‐κB pathway (Ivan et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary tea tree (Melaleuca alternifolia) oil and feeding patterns on the zootechnical performance and nonspecific immune response of the giant freshwater prawn (Macrobrachium rosenbergii)

Sun

et al. 2021

J World Aquaculture Soc

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This study investigated the effects of dietary tea tree oil (TTO) supplementation and feeding patterns on the growth and nonspecific immunity of Macrobrachium rosenbergii.Prawns were randomly assigned into four patterns. Patterns 1 (P1) and 4 (P4): prawns were fed with a basal diet and basal diet supplemented with 100 mg/kg of TTO, respectively; Patterns 2 (P2) and 3 (P3): prawns were fed with the basal diet supplemented with 100 mg/kg of TTO at 1-and 2-week intervals, respectively. A significant increase in growth performance was observed in the P3 and P4 compared with P1. The activities of antioxidant enzyme were significantly elevated in the P3 and P4 compared with the P1. The concentration of haemolymph malondialdehyde was significantly lower in the P3 and P4 than the P1. The haemolymph level of IL-1 and TNF-α was significantly lower in the P3 than the P4. The expression of toll and dorsal was significantly lower in the P3 than the P1. However, the

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Immunomodulatory effects of orally administrated florfenicol in rainbow trout (Oncorhynchus mykiss) following experimental challenge with streptococcosis/lactococcosis

Cited by 21 publications

References 50 publications

The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.)

Effects of dietary sweet basil (Ocimum basilicum) oil on the performance, antioxidants and immunity welfare, and resistance of Indian shrimp (Penaeus indicus) againstVibrio parahaemolyticusinfection

Effects of dietary tea tree (Melaleuca alternifolia) oil and feeding patterns on the zootechnical performance and nonspecific immune response of the giant freshwater prawn (Macrobrachium rosenbergii)

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