Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial

Sadrifar, Sina; Abbasi-Dokht, Tannaz; Forouzandeh, Sarvenaz; Malek, Farhad; Yousefi, Bahman; Karami, Jafar; Baharlou, Rasoul

doi:10.1186/s13223-022-00753-4

Cited by 13 publications

(9 citation statements)

References 39 publications

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“…Previous studies have shown an association between Lactobacillus administration and immune regulation of Th1/Th2 response, reducing allergic inflammation characteristic of asthma (14,28).…”

Section: Discussionmentioning

confidence: 97%

“…This change may have been due to the significant uptick in serum SCFAs which traveled through systemic circulation and reduced inflammation in the lungs. Previous studies have shown an association between Lactobacillus administration and immune regulation of Th1/Th2 response, reducing allergic inflammation characteristic of asthma (14, 28). The effect of the herbal extracts can also not be discounted, as turmeric, holy basil, and vasaka have antioxidant and anti-inflammatory properties (18, 29).…”

Section: Discussionmentioning

confidence: 99%

“…SCFAs and other metabolites produced by commensal bacteria travel through systemic circulation and mediate inflammatory and immune responses in distal organs (13). In a double-blind, randomized controlled trial of asthmatic patients, a Lactobacillus blend taken once a day for 8 weeks showed immunomodulatory effects via improvement in Th2 cells-associated IL-4 and lung function via forced expiratory volume and forced vital capacity (14). Adequate SCFA production is also associated with reduced allergic airway inflammation (15, 16).…”

Section: Introductionmentioning

confidence: 99%

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Clinical Trial of a Probiotic and Herbal Supplement for Lung and Gut Health

Wenger

Qiao

Nicola

et al. 2023

Preprint

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Rationale: Dysbiosis of the gut microbiome may augment lung disease via the gut-lung axis. Proteobacteria may increase MMP-9 release and contribute to tissue proteolysis followed by neutrophil recruitment, lung tissue injury, and perpetuation of chronic lung disease. Trial Design: We sought to determine if a probiotic and herbal blend was safe and well-tolerated in healthy volunteers and asthmatic patients. Methods: We conducted a 1-month randomized, open-label clinical trial in Cork, Ireland with healthy and asthmatic patients who took the blend twice a day. The primary endpoint was safety with secondary endpoints including quality of life, lung function, gut microbiome ecology, and inflammatory biomarkers. Results: All subjects tolerated the blend without adverse events. Asthmatic subjects who took the blend showed significant improvements in lung function and serum short chain fatty acid levels from baseline to Week 4. The gut microbiome of asthmatic subjects differed significantly from controls, with the most prominent difference in the relative abundance of the proteobacteria Escherichia coli. Administration of the probiotic maintained overall microbial community architecture with the only significant difference being an increase in absolute abundance of the probiotic strains measured by strain-specific PCR. Conclusions: This study supports the safety and efficacy potential of oral probiotic administration of the probiotic and herbal to act on the gut-lung axis.

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“…Previous studies have shown an association between Lactobacillus administration and immune regulation of Th1/Th2 response, reducing allergic inflammation characteristic of asthma (14,28).…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Trial of a Probiotic and Herbal Supplement for Lung and Gut Health

Wenger

Qiao

Nicola

et al. 2023

Preprint

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“…T-cell responses have a prominent role in immunity against COVID-19 as well as the progression of this disease. Interestingly, evidence on COVID-19 has shown that dysfunction or excessive immune response can contribute to the creation of cytokine storms, leading to rising in inflammatory mediators including IL-6, IL-8, MIP-1A, GM-CSF, and IFN-γ which caused massive damage to the respiratory system and tissue to break down [ 7 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

T-Cell Immune Responses and Immunological Factors Associated with Coronavirus Disease 2019 Progression as Predictors for the Severity of the Disease in Hospitalized Patients

Abbasi-Dokht¹,

Vafaeinezhad²,

Khalesi³

et al. 2023

Int Arch Allergy Immunol

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Introduction: The prevalence of coronavirus disease 2019 (COVID-19) has rapidly increased worldwide. More investigation is needed to progress toward understanding the exact role of immune responses in the pathology of the disease, leading to improved anticipation and treatment options. Methods: In the present study, we examined the relative expression of T-bet, GATA3, RORγt, and FoxP3 transcription factors as well as laboratory indicators in 79 hospitalized patients along with 20 healthy subjects as a control group. In order to make an exact comparison between various degrees of severity of disease, patients were divided into critical (n = 12) and severe (n = 67) groups. To evaluate the expression of genes of interest by performing real-time PCR, blood samples were obtained from each participant. Results: We found a significant increase in the expression of T-bet, GATA3, and RORγt and a reduction in the expression of FoxP3 in the critically ill patients compared to the severe and control groups. Also, we noticed that the GATA3 and RORγt expressions were elevated in the severe group in comparison with healthy subjects. Additionally, the GATA3 and RORγt expressions showed a positive correlation with elevation in CRP and hepatic enzyme concentration. Moreover, we observed that the GATA3 and RORγt expressions were the independent risk factors for the severity and outcome of COVID-19. Discussion: The present study showed that the overexpression of T-bet, GATA3, and RORγt, as well as a decrease in the FoxP3 expression was associated with the severity and fatal outcome of COVID-19.

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“…93 Supplementation with a probiotic mixture of multiple Lactobacilli, B. longum, and Streptococcus thermophilus in adults with asthma resulted in an improvement of lung function, a reduction in several inflammatory markers and an increase in regulatory markers. [94][95][96] However, in longitudinal studies, supplementation with L. reuteri, L. rhamnosus, or B. lactis or a mix of Lactobacilli and Bifidobacteria to pregnant women in the last month of pregnancy, 3-6 months postpartum, and after birth to their newborns till 6 months to 2 years of age did not induce a difference in asthma incidence at school age. [97][98][99][100] In conclusion, the in vivo interventions described above only seem to influence asthma symptoms in children above 3 years and adults and do not prevent asthma development, when given during pregnancy and in newborns.…”

Section: Interventi On S Tud Ie Smentioning

confidence: 93%

Influence of the gut and airway microbiome on asthma development and disease

Smulders,

Van Der Schee,

Maitland‐Van Der Zee

et al. 2024

Pediatric Allergy Immunology

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There are ample data to suggest that early‐life dysbiosis of both the gut and/or airway microbiome can predispose a child to develop along a trajectory toward asthma. Although individual studies show clear associations between dysbiosis and asthma development, it is less clear what (collection of) bacterial species is mechanistically responsible for the observed effects. This is partly due to issues related to the asthma diagnosis and the broad spectrum of anatomical sites, sample techniques, and analysis protocols that are used in different studies. Moreover, there is limited attention for potential differences in the genetics of individuals that would affect the outcome of the interaction between the environment and that individual. Despite these challenges, the first bacterial components were identified that are able to affect the transcriptional state of human cells, ergo the immune system. Such molecules could in the future be the basis for intervention studies that are now (necessarily) restricted to a limited number of bacterial species. For this transition, it might be prudent to develop an ex vivo human model of a local mucosal immune system to better and safer explore the impact of such molecules. With this approach, we might move beyond association toward understanding of causality.

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Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial

Cited by 13 publications

References 39 publications

Clinical Trial of a Probiotic and Herbal Supplement for Lung and Gut Health

Clinical Trial of a Probiotic and Herbal Supplement for Lung and Gut Health

T-Cell Immune Responses and Immunological Factors Associated with Coronavirus Disease 2019 Progression as Predictors for the Severity of the Disease in Hospitalized Patients

Influence of the gut and airway microbiome on asthma development and disease

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