Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?

Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells

“…Use of probiotic bacteria can increase abundance and concurrently modulate immune cells, including B, T helper (Th)-1, Th-2, Th-17 and regulatory T (Treg) cells. This in turn, directly influences human health and modulates pathologies of immune/autoimmune diseases [1,2,13]. In fact, we previously noted that S. thermophilus 1342, S. thermophilus 1275 and S. thermophilus 285 modulate the U937 monocyte cell line.…”

“…The majority of probiotics belong to the lactic acid bacteria (LAB) family; gram positive lactic acid producing microorganisms that include several genera such as bifidobacteria, lactobacilli streptococci and enterococci [1]. The small intestine and the colon are highly enriched with these microorganisms [6][7][8], which are routinely supplemented in foods as live strains due to their beneficial effects on human health [1,2,[8][9][10][11][12][13]. Streptococcus species such as exopolysaccharide-producing strains of Streptococcus thermophilus (ST) [12,14,15] are among those consumed.…”

Streptococcus thermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

“…Probiotics have long been implicated for the overall improvement of health and the management of a number of health conditions including infection, constipation, allergies, and autoimmune diseases, and are either consumed in the form of different fermented foods and dairy products or taken as capsules. In either case, there is strong evidence that suggests that the ingestion of probiotics can alter intestinal dysbiosis and relieve dysfunctionality complications, with subsequent improvements to health [3].…”

“…Probiotic bacteria have been evolved inside the human intestinal tract (GIT), and through this co-evolution, the gut and its microbiome have developed a symbiotic relationship that is of mutual benefit. While the GIT microflora relies on the gut's warm habitat and food content, in return, it not only provides numerous unique bioactive components such as vitamins B and K, minerals, short chain fatty acids (SCF), and miosins to the host, but it also assists in modulating the immune system [3]. In fact, probiotics are able to modulate monocytes, macrophages, B cells, T helper (h)1, Th2, Th17, regulatory T cells (Treg), natural killer (NK) cells, and dendritic cells (DC) [3][4][5][6].…”

Efeitos da administração perinatal da levedura Saccharomyces cerevisiae UFMG A-905 na prevenção da asma na prole de camundongos

“…Em estudos clínicos, doenças como dermatite atópica, eczema e rinite alérgica foram prevenidas, ou tiveram seus sintomas diminuídos, após a administração de diferentes cepas de probióticos -como o L. rhamnosus GG, B. lactis e B. animalis(85).Em relação à aplicação de probióticos para a prevenção da asma em estudos clínicos, a sua utilização não apresentou resultados significativos até momento. Porém, diversos Semelhante aos nossos achados, no estudo citado acima, em que a A. lwoffii F78 foi administrada intranasal, os autores avaliaram os efeitos após a exposição aguda e crônica ao probiótico e também identificaram uma resposta mais eficiente no grupo que recebeu o probiótico por menos tempo.…”