2018
DOI: 10.1182/blood-2018-99-115894
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Immunomodulatory Effects of Proteasome Inhibitors in Multiple Myeloma

Abstract: 【 Background and purpose 】Introduction of novel drugs such as immunomodulatory drugs (IMIDs), and proteasome inhibitors has significantly prolonged survival of multiple myeloma (MM). However, MM harboring high-risk cytogenic changes such as del 17 and t(4;14) is still significantly associated with short survival. Immunotherapy including monoclonal antibodies against MM cells or chimeric antigen receptor expressing T cell (CAR-T) therapy has also showed excellent response to high-risk MM, although the cost of t… Show more

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“…To exploit the pathway of cell death, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed (Figure c). Notably, the inactivation of proteasome in the M-3+L group was observed to cause cell apoptosis or necrosis . Therefore, it is speculated that ICD was induced by mild heating through the perturbation of proteasome signaling pathway …”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…To exploit the pathway of cell death, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed (Figure c). Notably, the inactivation of proteasome in the M-3+L group was observed to cause cell apoptosis or necrosis . Therefore, it is speculated that ICD was induced by mild heating through the perturbation of proteasome signaling pathway …”
Section: Resultsmentioning
confidence: 99%
“…Notably, the inactivation of proteasome in the M-3+L group was observed to cause cell apoptosis or necrosis. 55 Therefore, it is speculated that ICD was induced by mild heating through the perturbation of proteasome signaling pathway. 56 To further elucidate the antitumor immunity mediated by M-3 nanohybrids under NIR light irradiation, 58 immunerelated genes among the differential genes were further screened (Figure 7d).…”
Section: Effects Of Nanohybrids On DC Maturationmentioning
confidence: 99%