Immunomodulatory effects of Turkish propolis: Changes in neopterin release and tryptophan degradation

Girgin, Gözde; Baydar, Terken; Ledochowski, Maximilian; Schennach, Harald; Bölükbasi, Duygu Nur; Sorkun, Kadriye; Salih, Bekir; Şahin, Gönül; Fuchs, Dietmar

doi:10.1016/j.imbio.2008.07.002

Cited by 34 publications

(21 citation statements)

References 32 publications

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“…Our findings were also consistent with those of Wang et al, who showed that Chinese propolis extracts decreased the expression of LPS-induced NF-kB by inhibiting phosphorylation of Ikb and that this reduced TNF-a levels [20]. Girgin et al showed that the immunomodulatory effects of Turkish propolis on peripheral blood mononuclear cell cultures were dose dependent and involved decreased cytokine release [21]. However, the present study was the first to investigate the anti-inflammatory effects of propolis from Sakarya region of Turkey on experimental acute inflammatory uveitis.…”

Section: Discussionsupporting

confidence: 92%

Anti-inflammatory and ultrastructural effects of Turkish propolis in a rat model of endotoxin-induced uveitis

Ertürküner

Saraç

Göçmez

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Experimental animal models of acute uveitis, an inflammatory eye disease, can be established via endotoxin-induced inflammation. Propolis, a natural substance collected by honeybees from buds and tree exudates, has antioxidant, antibacterial, antiviral, and anti-inflammatory effects. We investigated the effects of propolis, obtained from the Sakarya province of Turkey, on endotoxin-induced uveitis using immunohistochemical, ultrastructural, and biochemical approaches. Material and methods. Male Wistar albino rats (n = 6/group) received intraperitoneal (ip) lipopolysaccharide (LPS) endotoxin (150 µg/kg) followed by aqueous extract of propolis (50 mg/kg ip) or vehicle; two additional groups received either saline (control) or propolis only. After 24 h, aqueous humor (AH) was collected from both eyes of each animal for analysis of tumor necrosis factor-a (TNF-a) and hypoxia-inducible factor-1a (HIF-1a). Right eyeballs were paraffin-embedded for immunohistochemical staining of nuclear factor kB (NF-kB)/p65 and left eyeballs were araldite-embedded for ultrastructural analysis. Results. Treatment of LPS-induced uveitis with propolis significantly reduced ciliary body NF-kB/p65 immunoreactivity and AH levels of HIF-1a and TNF-a. Ultrastructural analysis showed fewer vacuoles and reduced mitochondrial degeneration in the retinal pigment epithelium, as compared to the uveitis group. The intercellular spaces of the inner nuclear layer and outer limiting membrane were comparable with those of the control group; no polymorphonuclear cells or stasis was observed in intravascular or extravascular spaces. Conclusions. This is the first report demonstrating an anti-inflammatory effect of Turkish propolis in a rat model of LPS-induced acute uveitis, suggesting a therapeutic potential of propolis for the treatment of inflammatory ophthalmic diseases.

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Section: Discussionsupporting

confidence: 92%

Anti-inflammatory and ultrastructural effects of Turkish propolis in a rat model of endotoxin-induced uveitis

Ertürküner

Saraç

Göçmez

et al. 2015

Folia Histochem Cytobiol.

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“…O. Kuntze (Bankova et al, 1999). Propolis possesses several biological properties, such as antibacterial, antifungal, antiprotozoan, antiviral, antitumoral, anti-infl ammatory, immunomodulatory, among others (Banskota et al, 2001;Bazo et al, 2002;Freitas et al, 2006;Sforcin, 2007;Girgin et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Propolis immunomodulatory action in vivo on Toll‐like receptors 2 and 4 expression and on pro‐inflammatory cytokines production in mice

Orsatti

Missima

Pagliarone

et al. 2010

Phytotherapy Research

124

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Propolis is a bee product and its immunomodulatory action has been the subject of intense investigation lately. The recent discovery and characterization of the family of Toll-like receptors (TLR) have triggered a great deal of interest in the field of innate immunity due to their crucial role in microbial recognition and development of the adaptive immune response. This work aimed to evaluate propolis's effect on TLR-2 and TLR-4 expression and on the production of pro-inflammatory cytokines (IL-1beta and IL-6). Male BALB/c mice were treated with propolis (200 mg/kg) for three consecutive days, and TLR-2 and TLR-4 expression as well as IL-1beta and IL-6 production were assessed in peritoneal macrophages and spleen cells. Basal IL-1beta production and TLR-2 and TLR-4 expression were increased in peritoneal macrophages of propolis-treated mice. TLR-2 and TLR-4 expression and IL-1beta and IL-6 production were also upregulated in the spleen cells of propolis-treated mice. One may conclude that propolis activated the initial steps of the immune response by upregulating TLRs expression and the production of pro-inflammatory cytokines in mice, modulating the mechanisms of the innate immunity.

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“…In addition, propolis is known for its anti-inflammatory (Hu et al, 2005) and immuno-modulatory function (Orsolic and Basic, 2003). Propolis extract from Turkey (Girgin et al, 2009) and ingredients such as quercetin, CAPE and hesparidin (Ansorge et al, 2003) were found to suppress immune cells activation.…”

Section: Introductionmentioning

confidence: 99%

Brazilian green propolis and its constituent, Artepillin C inhibits allogeneic activated human CD4 T cells expansion and activation

Cheung

Sze

Chan

et al. 2011

Journal of Ethnopharmacology

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Immunomodulatory effects of Turkish propolis: Changes in neopterin release and tryptophan degradation

Cited by 34 publications

References 32 publications

Anti-inflammatory and ultrastructural effects of Turkish propolis in a rat model of endotoxin-induced uveitis

Anti-inflammatory and ultrastructural effects of Turkish propolis in a rat model of endotoxin-induced uveitis

Propolis immunomodulatory action in vivo on Toll‐like receptors 2 and 4 expression and on pro‐inflammatory cytokines production in mice

Brazilian green propolis and its constituent, Artepillin C inhibits allogeneic activated human CD4 T cells expansion and activation

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