Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

Zhang, Chaofan; Cai, Erya; Qi, Xiaoliang; Ge, XinXin; Xiang, Yajing; Wang, Jiajia; Li, Ying; Lv, Lizhang; Zheng, Hui; Qian, Yuna; Dong, Wei; Li, He; Shen, Jianliang

doi:10.1016/j.cej.2024.150756

Cited by 22 publications

(1 citation statement)

References 51 publications

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“…It can help antibacterial agents to inhibit bacterial infection through immune reaction . Especially, if the superfluous ROS is not removed in time, it can lead to oxidative stress, such as an inflammatory response, which would recruit white blood cells and other immune cells to kill bacteria . In this way, the bacteria colonized on the surface of the positively postcharged SnO 2 @RuO 2 were effectively killed with the help of immune cells.…”

Section: Resultsmentioning

confidence: 99%

Electrical Responsive Coating with a Multilayered TiO₂–SnO₂–RuO₂ Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration

Zhou,

Liu,

et al. 2024

ACS Appl. Mater. Interfaces

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The bacterial infection and poor osseointegration of Ti implants could significantly compromise their applications in bone repair and replacement. Based on the carrier separation ability of the heterojunction and the redox reaction of pseudocapacitive metal oxides, we report an electrically responsive TiO 2 −SnO 2 −RuO 2 coating with a multilayered heterostructure on a Ti implant. Owing to the band gap structure of the TiO 2 −SnO 2 − RuO 2 coating, electron carriers are easily enriched at the coating surface, enabling a response to the endogenous electrical stimulation of the bone. With the formation of SnO 2 −RuO 2 pseudocapacitance on the modified surface, the postcharging mode can significantly change the surface chemical state of the coating due to the redox reaction, enhancing the antibacterial ability and osteogenesis-related gene expression of the human bone marrow mesenchymal stem cells. Owing to the attraction for Ca 2+ , only the negatively postcharged SnO 2 @RuO 2 can promote apatite deposition. The in vivo experiment reveals that the S−SnO 2 @RuO 2 -NP could effectively kill the bacteria colonized on the surface and promote osseointegration with the synostosis bonding interface. Thus, negatively charging the electrically responsive coating of TiO 2 −SnO 2 −RuO 2 is a good strategy to endow modified Ti implants with excellent antibacterial ability and osseointegration.

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Section: Resultsmentioning

confidence: 99%

Electrical Responsive Coating with a Multilayered TiO₂–SnO₂–RuO₂ Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration

Zhou,

Liu,

et al. 2024

ACS Appl. Mater. Interfaces

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Double Enzyme Active Hydrogel Program Regulates the Microenvironment of Staphylococcus aureus‐Infected Pressure Ulcers

Xie,

Qian,

Ding

et al. 2024

Adv Healthcare Materials

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The treatment of infected pressure ulcers (IUPs) requires addressing diverse microenvironments. A pressing challenge is to effectively enhance the regenerative microenvironment at different stages of the healing process, tailoring interventions as needed. Here, a dual enzyme mimetic and bacterial responsive self‐activating antimicrobial hydrogel designed to enhance IPUs healing is introduced. This hydrogel incorporates pH‐responsive dual enzyme‐active nanoplatforms (HNTs‐Fe‐Ag) encapsulated within a methacrylate‐modified silk fibroin (SFMA) and dopamine methacrylamide (DMA) matrix. This composite hydrogel exhibits adaptive microenvironment regulation capabilities. Under the low pH microenvironment of bacterial infection, it has excellent antimicrobial activity by self‐activating the •OH generation in conjunction with photothermal effects. Under the neutral and alkaline microenvironment of chronic inflammation, it catalyzes the decomposition of hydrogen peroxide (H2O2) to produce oxygen (O2), thereby alleviating hypoxia and scavenging reactive oxygen species (ROS), which in turn remodulates the phenotype of macrophages. The composite hydrogel demonstrates on‐demand therapeutic effects in the microenvironment of infected wounds, significantly enhancing the regenerative microenvironment of IUPs by promoting wound closure, inflammation regulation, and collagen deposition through self‐activated antimicrobial action during infection and adaptive hypoxia relief during recovery. This approach offers a novel strategy for developing smart wound dressings.

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Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes

Chen,

Li,

et al. 2024

Advanced Science

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Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due to poor adherence, short retention time in the mouth, and less‐than‐optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made of a silk fibroin/hyaluronic acid matrix with light‐sensitive adhesive qualities infused with ferric iron/shikonin nanoparticles to enhance healing effects is presented. Initially, this hydrogel forms an adhesive barrier over mucosal lesions through a straightforward local injection, solidifying when exposed to UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination and near‐infrared photothermal bactericidal activity. These characteristics support bacterial elimination and regulate oxidative levels, promoting a wound's progression from inflammation to tissue regeneration. In a diabetic rat model mimicking oral ulcers, FSH3 significantly speeds up healing by adjusting the inflammatory environment of the injured tissue, maintaining balance in oral microbiota, and promoting faster re‐epithelialization. Overall, the light‐sensitive FSH3 hydrogel shows potential for rapid wound recovery and may transform therapeutic methods for managing oral ulcers in diabetes.

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Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

Cited by 22 publications

References 51 publications

Electrical Responsive Coating with a Multilayered TiO₂–SnO₂–RuO₂ Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration

Electrical Responsive Coating with a Multilayered TiO₂–SnO₂–RuO₂ Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration

Double Enzyme Active Hydrogel Program Regulates the Microenvironment of Staphylococcus aureus‐Infected Pressure Ulcers

Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes

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Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

Cited by 22 publications

References 51 publications

Electrical Responsive Coating with a Multilayered TiO2–SnO2–RuO2 Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration

Electrical Responsive Coating with a Multilayered TiO2–SnO2–RuO2 Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration

Double Enzyme Active Hydrogel Program Regulates the Microenvironment of Staphylococcus aureus‐Infected Pressure Ulcers

Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes

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Product

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Electrical Responsive Coating with a Multilayered TiO₂–SnO₂–RuO₂ Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration

Electrical Responsive Coating with a Multilayered TiO₂–SnO₂–RuO₂ Heterostructure on Ti for Controlling Antibacterial Ability and Improving Osseointegration