Immunomodulatory impact of α-fetoprotein

Munson, Paul V.; Adamik, Juraj; Butterfield, Lisa H.

doi:10.1016/j.it.2022.04.001

Cited by 31 publications

(25 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Munson et al observed the in vitro tAFP ability to supress monocyte function, rather than frequency, via supressing their ability to produce TNFα and IL-1β[52].Intermediate monocytes% showed signi cant negative correlation with HDL-C (r= -0.225, p=0.046) agreeing with Rogacev et al[53]. Idzkowska et al[54] provided evidence that in ammation could induce lipid dysregulation mainly through the modulation of monocytes recruitment and activation.…”

mentioning

confidence: 64%

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Hammad

Dosoky

Madbouly

et al. 2023

Preprint

View full text Add to dashboard Cite

Cirrhosis-associated immune dysfunction (CAID) is an immunological perturbation that develops on top of liver cirrhosis (LC). Immune perturbation directs LC progression to hepatocellular carcinoma (HCC). Innate immune cells, in particular, monocytes, play key roles in inflammation and tumorigenesis. MicroRNAs (miRs) have been regarded as master regulators of the immune networks. We aim to investigate the altered monocytes subsets distribution in LC and subsequent HCC in association with the expression level of plasma homo sapiens (hsa)-miR-21-5p and hsa-miR-155-5p. A step toward non-protein coding (nc) RNA precision medicine based on the immune perturbation, manifested as altered monocytes distribution, on top of LC and HCC. Subjects and Methods: Seventy-nine patients diagnosed with chronic hepatitis C virus (CHCV) infection with LC were enrolled in the current study. Patients were sub-classified into LC group without HCC (n=40), LC with HCC (n=39), and 15 apparently healthy controls. Monocyte subsets frequencies were assessed by flow-cytometry. Real-time quantitative PCR was used to measure plasma hsa-miR-21-5p and hsa-miR-155-5p expression. Results: hsa-miR-21-5p correlated with intermediate monocytes (r=0.30, p=0.007), while hsa-miR-155-5p negatively correlated with nonclassical monocytes (r= -0.316, p=0.005). ROC curve analysis revealed that combining intermediate monocytes frequency and hsa-miR-21 yielded sensitivity= 79.5%, specificity= 75%, and AUC= 0.84. In comparison, AFP yielded a lower sensitivity = 69% and 100% specificity with AUC= 0.85. Logistic regression analysis proved that up-regulation of intermediate monocytes frequency and hsa-miR-21-5p were independent risk factors for LC progression to HCC, after adjustment for co-founders. Conclusion: Monocyte subsets differentiation in HCC was linked to hsa-miR-21-5p and hsa-miR-155-5p. Combined up-regulation of intermediate monocytes frequency and hsa-miR-21-5p expression could be considered a sensitive indicator of LC development to HCC. Circulating intermediate monocytes and hsa-miR-21-5p were independent risk factors for HCC evolution, clinically and in silicoproofed.

show abstract

mentioning

confidence: 64%

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Hammad

Dosoky

Madbouly

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Among the 33 DEPs identified via DIA, 16 were selected and used in PRM analysis. We selected 16 proteins based on the p -value and fold change, and these are all closely related to autoimmunity. − The screening criteria were formulated as proteins having a high area under the curve (AUC) values or significant p -values. The results demonstrated that the abundance of four proteins was elevated and that of 12 proteins was reduced in the BA group compared with that in the IHC group.…”

Section: Resultsmentioning

confidence: 99%

Proteomics Defines Plasma Biomarkers for the Early Diagnosis of Biliary Atresia

Fu,

Guo,

Chen

et al. 2024

J. Proteome Res.

View full text Add to dashboard Cite

Early diagnosis of biliary atresia (BA) is crucial for improving the chances of survival and preserving the liver function of pediatric patients with BA. Herein, we performed proteomics analysis using dataindependent acquisition (DIA) and parallel reaction monitoring (PRM) to explore potential biomarkers for the early diagnosis of BA compared to other non-BA jaundice cases. Consequently, we detected and validated differential protein expression in the plasma of patients with BA compared to the plasma of patients with intrahepatic cholestasis. Bioinformatics analysis revealed the enriched biological processes characteristic of BA by identifying the differential expression of specific proteins. Signaling pathway analysis revealed changes in the expression levels of proteins associated with an alteration in immunoglobulin levels, which is indicative of immune dysfunction in BA. The combination of polymeric immunoglobulin receptor expression and immunoglobulin lambda variable chain (IGL c2225_light_IGLV1-47_IGLJ2), as revealed via machine learning, provided a useful early diagnostic model for BA, with a sensitivity of 0.8, specificity of 1, accuracy of 0.89, and area under the curve value of 0.944. Thus, our study identified a possible effective plasma biomarker for the early diagnosis of BA and could help elucidate the underlying mechanisms of BA.

show abstract

“…Dendritic cells are well-known immunologically presenting cells, and immature dendritic cells predominantly produce immunomodulatory factors to mediate central and peripheral immune responses ( 69 ). Tol DCs are a subtype of dendritic cells that promote T reg cell activity, reduce Th1 and Th2 inflammation, and inhibit effector T cells ( 70 ).…”

Section: Tolerogenic Dendritic Cells (Tol Dcs)mentioning

confidence: 99%

Novel potential therapeutic targets of alopecia areata

Wan

Xie

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Alopecia areata (AA) is a non-scarring hair loss disorder caused by autoimmunity. The immune collapse of the hair follicle, where interferon-gamma (IFN-γ) and CD8+ T cells accumulate, is a key factor in AA. However, the exact functional mechanism remains unclear. Therefore, AA treatment has poor efficacy maintenance and high relapse rate after drug withdrawal. Recent studies show that immune-related cells and molecules affect AA. These cells communicate through autocrine and paracrine signals. Various cytokines, chemokines and growth factors mediate this crosstalk. In addition, adipose-derived stem cells (ADSCs), gut microbiota, hair follicle melanocytes, non-coding RNAs and specific regulatory factors have crucial roles in intercellular communication without a clear cause, suggesting potential new targets for AA therapy. This review discusses the latest research on the possible pathogenesis and therapeutic targets of AA.

show abstract

Immunomodulatory impact of α-fetoprotein

Cited by 31 publications

References 62 publications

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Monocytes Subsets Altered Distribution and Dysregulated Plasma hsa-miR-21-5p and hsa- miR-155-5p in HCV-Linked Liver Cirrhosis Progression to Hepatocellular Carcinoma

Proteomics Defines Plasma Biomarkers for the Early Diagnosis of Biliary Atresia

Novel potential therapeutic targets of alopecia areata

Contact Info

Product

Resources

About