Immunomodulatory properties of a strain of Mycobacterium chelonae I. Mouse lymphocyte responses in vitro

Adjuvant activity of polar glycopeptidolipids fromMycobacterium chelonaein experimental vaccines againstAeromonas salmonicidain salmonid fish

“…GPLs have been described as behaving as B-cell mitogens in mice, exerting a similar e#ect to LPS (Neway et al, 1989); the responsiveness of murine lymphocytes to cells of M. chelonae being shown to be dose dependent. Leucocytes from rainbow trout injected with pGPL-Mc in vivo responded slightly better to a 100 g ml 1 dose of LPS, than cells from fish injected with saline, indicating that B-cells are stimulated by this injection.…”

“…This bacterium has also been isolated from abscesses in humans (Grange, 1981). Live bacteria have shown immunomodulating properties on cell-mediated and humoral immune responses in the mouse (Neway et al, 1989(Neway et al, , 1990(Neway et al, , 1992. Gjata et al (1994) reported that in mice, polar glycopeptidolipids from M. chelonae (pGPL-Mc) showed adjuvant activity on the immunogenic and protective e#ects of an inactivated influenza vaccine.…”