Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Wassmer, Charles-Henri; Berishvili, Ekaterine

doi:10.1007/s11892-020-01316-w

Cited by 65 publications

(58 citation statements)

References 114 publications

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“…Moreover, hAECs have tri-mesodermal lineage differentiation potential; they can produce osteogenic, adipogenic, and chondrogenic lineages under appropriate culture conditions [ 17 ]. Notably, hAECs have low expression levels of human leukocyte antigens (including HLA-A, HLA-B, and HLA-C and HLA-DR), which are key antigens involved in recipient rejection [ 1 , 18 ]. A study confirmed that intravenous administration of hAECs did not result in hemolysis, allergic reactions, toxicity, or tumor formation, which demonstrated that hAECs were systematically safe [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Application of human amniotic epithelial cells in regenerative medicine: a systematic review

Zhang

Lai

2020

Stem Cell Res Ther

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Human amniotic epithelial cells (hAECs) derived from placental tissues have gained considerable attention in the field of regenerative medicine. hAECs possess embryonic stem cell-like proliferation and differentiation capabilities, and adult stem cell-like immunomodulatory properties. Compared with other types of stem cell, hAECs have special advantages, including easy isolation, plentiful numbers, the obviation of ethical debates, and non-immunogenic and non-tumorigenic properties. During the past two decades, the therapeutic potential of hAECs for treatment of various diseases has been extensively investigated. Accumulating evidence has demonstrated that hAEC transplantation helps to repair and rebuild the function of damaged tissues and organs by different molecular mechanisms. This systematic review focused on summarizing the biological characteristics of hAECs, therapeutic applications, and recent advances in treating various tissue injuries and disorders. Relevant studies published in English from 2000 to 2020 describing the role of hAECs in diseases and phenotypes were comprehensively sought out using PubMed, MEDLINE, and Google Scholar. According to the research content, we described the major hAEC characteristics, including induced differentiation plasticity, homing and differentiation, paracrine function, and immunomodulatory properties. We also summarized the current status of clinical research and discussed the prospects of hAEC-based transplantation therapies. In this review, we provide a comprehensive understanding of the therapeutic potential of hAECs, including their use for cell replacement therapy as well as secreted cytokine and exosome biotherapy. Moreover, we showed that the powerful immune-regulatory function of hAECs reveals even more possibilities for their application in the treatment of immune-related diseases. In the future, establishing the optimal culture procedure, achieving precise and accurate treatment, and enhancing the therapeutic potential by utilizing appropriate preconditioning and/or biomaterials would be new challenges for further investigation.

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Section: Methodsmentioning

confidence: 99%

Application of human amniotic epithelial cells in regenerative medicine: a systematic review

Zhang

Lai

2020

Stem Cell Res Ther

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“…Perinatal stem cells are not immunogenic and are in a state of immune tolerance. Perinatal stem cells do not express HLA class II antigens (HLA-DR) or the co-stimulatory molecules CD40, CD80, and CD86 that are required for T cell activation [ 121 , 122 ]. However, HLA-DR expression increases after in vitro stimulation with IFN-ɣ or when cultured without serum.…”

Section: Immunological Properties Of Perinatal Stem Cellsmentioning

confidence: 99%

Current Status and Future Prospects of Perinatal Stem Cells

Torre

Flores

2020

Genes

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The placenta is a temporary organ that is discarded after birth and is one of the most promising sources of various cells and tissues for use in regenerative medicine and tissue engineering, both in experimental and clinical settings. The placenta has unique, intrinsic features because it plays many roles during gestation: it is formed by cells from two individuals (mother and fetus), contributes to the development and growth of an allogeneic fetus, and has two independent and interacting circulatory systems. Different stem and progenitor cell types can be isolated from the different perinatal tissues making them particularly interesting candidates for use in cell therapy and regenerative medicine. The primary source of perinatal stem cells is cord blood. Cord blood has been a well-known source of hematopoietic stem/progenitor cells since 1974. Biobanked cord blood has been used to treat different hematological and immunological disorders for over 30 years. Other perinatal tissues that are routinely discarded as medical waste contain non-hematopoietic cells with potential therapeutic value. Indeed, in advanced perinatal cell therapy trials, mesenchymal stromal cells are the most commonly used. Here, we review one by one the different perinatal tissues and the different perinatal stem cells isolated with their phenotypical characteristics and the preclinical uses of these cells in numerous pathologies. An overview of clinical applications of perinatal derived cells is also described with special emphasis on the clinical trials being carried out to treat COVID19 pneumonia. Furthermore, we describe the use of new technologies in the field of perinatal stem cells and the future directions and challenges of this fascinating and rapidly progressing field of perinatal cells and regenerative medicine.

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“…However, MSCs harvesting is an invasive procedure, their numbers and properties decrease with donor’s age, and they have a potential for tumorigenicity [85,86]. Amniotic epithelial cells (AECs) are an alternative source of cells with similar properties [87]. These cells are derived from the amniotic membrane and are involved in the modulation of materno‐fetal tolerance during pregnancy [88].…”

Section: Improved Pseudo‐islets: the Benefits Of Adding Supporting Cementioning

confidence: 99%

Generation of insulin‐secreting organoids: a step toward engineering and transplanting the bioartificial pancreas

et al. 2020

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Summary Diabetes is a major health issue of increasing prevalence. ß‐cell replacement, by pancreas or islet transplantation, is the only long‐term curative option for patients with insulin‐dependent diabetes. Despite good functional results, pancreas transplantation remains a major surgery with potentially severe complications. Islet transplantation is a minimally invasive alternative that can widen the indications in view of its lower morbidity. However, the islet isolation procedure disrupts their vasculature and connection to the surrounding extracellular matrix, exposing them to ischemia and anoikis. Implanted islets are also the target of innate and adaptive immune attacks, thus preventing robust engraftment and prolonged full function. Generation of organoids, defined as functional 3D structures assembled with cell types from different sources, is a strategy increasingly used in regenerative medicine for tissue replacement or repair, in a variety of inflammatory or degenerative disorders. Applied to ß‐cell replacement, it offers the possibility to control the size and composition of islet‐like structures (pseudo‐islets), and to include cells with anti‐inflammatory or immunomodulatory properties. In this review, we will present approaches to generate islet cell organoids and discuss how these strategies can be applied to the generation of a bioartificial pancreas for the treatment of type 1 diabetes.

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Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Cited by 65 publications

References 114 publications

Application of human amniotic epithelial cells in regenerative medicine: a systematic review

Application of human amniotic epithelial cells in regenerative medicine: a systematic review

Current Status and Future Prospects of Perinatal Stem Cells

Generation of insulin‐secreting organoids: a step toward engineering and transplanting the bioartificial pancreas

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