Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications

Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis

“…It has been proposed that RIOM is a five phase inflammatory reaction to radiation injury [126]. MSCs have been reported to have anti-inflammatory properties [56,[144][145][146][147]. These anti-inflammatory properties are mediated by their secretion of PGE-2, NO, TGF-β , IL-10, HGF and IDO.…”

Acute Genotoxic Stress-Induced Senescence in Human Mesenchymal Cells Drives a Unique Composition of Senescence Messaging Secretome (SMS)

“…There is overwhelming evidence that MSC in their natural environment secrete both pro-and anti-inflammatory cytokines as well as their antagonists [51]. Such secretions triggered cellular communication circuitry and have been shown to provide sophisticated signaling guidance to many immune cells, including T cells, natural killer cells, B cells, monocytes, macrophages and dendritic cells [25,47,[52][53][54]. hADSCs senescence considerably alters the composition of SMS and this alteration might result in an impairment or enhancement of the immunomodulatory properties.…”

Aqueous biological graphene based formulations for ink-jet printing

“…The obtained ADSC are capable of differentiating into several specialized cell types, including osteoblasts, chondrocytes, adipocytes, myocytes, hepatocytes and pancreatic islets 6 . ADSC exert potent immunomodulatory effects 7 and produce high amounts of growth factors, cytokines and chemokines 8 . All those features of ADSC make them particularly useful for tissue regeneration or replacement in a number of clinical disorders.…”