Immunomodulatory properties of mesenchymal stromal/stem cells: The link with metabolism

Li, Hanyue; Dai, Hongwei; Li, Jie

doi:10.1016/j.jare.2022.05.012

Cited by 35 publications

(21 citation statements)

References 196 publications

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“…Recently, the immunomodulatory capacities of MSCs, including macrophage regulation, have been reported to be associated with metabolism and their therapeutic effects [ [16] , [17] , [18] , [19] ]. Indoleamine 2,3-dioxygenase (IDO) is not only regarded as a core immunoregulator but also an initial rate-limiting enzyme of tryptophan (Trp) metabolism, catalyzing Trp to kynurenine (Kyn) and further breaking down into other intermediates [ 20 ], which played critical roles in macrophage polarization [ [21] , [22] , [23] ].…”

Section: Introductionmentioning

confidence: 99%

Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway

Yuan

Chen

et al. 2022

Molecular Metabolism

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Section: Introductionmentioning

confidence: 99%

Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway

Yuan

Chen

et al. 2022

Molecular Metabolism

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“…In our study, we found increased KYNA/KYN ratio, a substitute of kynurenine aminotransferase (KAT) activity, in umbilical cord tissue but not in the maternal placenta or fetal membrane samples. One possible explanation for this nding is the increased amino acid metabolism of the human umbilical cord mesenchymal stem cells, which is essential for its biological function and proliferation 37 . The study of Wang and colleagues reported a high expression of the KAT II isoenzyme in the human umbilical cord mesenchymal stem cells, which catalyzes the conversion of KYN to KYNA 38 .…”

Section: Discussionmentioning

confidence: 99%

LC-MS/MS-based Quantification of Tryptophan, Kynurenine, and Kynurenic Acid in Human Placental, Fetal Membranes, and Umbilical Cord Samples

Pedraz-Petrozzi

Marszałek‐Grabska

Kozub

et al. 2023

Preprint

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Tryptophan breakdown metabolites formed along kynurenine pathway play a significant role in pregnancy and fetal development. To understand the involvement of tryptophan (TRP), kynurenine (KYN), and kynurenic acid (KYNA) in these phenomena, it is essential to quantify their levels in relevant biological samples, such as the placenta, fetal membranes, and umbilical cord. In this study, the level of TRP, KYN, and KYNA was determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The LC-MS/MS method was optimized for high sensitivity and specificity; it showed good reproducibility with a precision of <10% CV and an accuracy of 85-115%. The lower limit of quantification was 0.5 µg/ml for both TRP and KYN and 0.5 ng/mL for KYNA. The method was linear over the examined range of concentrations in homogenate: 0.5 to 30 µg/ml for both TRP and KYN and 0.5 to 25 ng/ml for KYNA. Maternal placenta samples exhibited lower KYNA concentrations but higher KYN concentrations and significantly increased KYN/TRP ratio. However, the umbilical cord had a significantly higher KYNA/KYN ratio than the other two analyzed tissues. No differences were observed in the KYNA/TRP ratio. Collectively, this finding may facilitate further research and provide inside into the involvement of kynurenine pathway of TRP metabolism in fetal development.

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“…They can suppress the activation of immune cells, such as T cells and macrophages, and promote the generation of regulatory T cells (Tregs) [ 52 ]. When MSCs are primed with H 2 , this immunomodulatory capacity is further enhanced [ 53 ]. H 2 can influence the expression of molecules involved in immune regulation, thereby improving MSCs’ ability to modulate immune responses [ 53 ].…”

Section: Mechanisms Of Msc Priming Using Molecular Hydrogenmentioning

confidence: 99%

Mesenchymal Stem Cell Priming: Potential Benefits of Administration of Molecular Hydrogen

Artamonov,

LeBaron,

Pyatakovich

et al. 2024

Pharmaceuticals

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Stem cell therapy has emerged as a promising avenue for regenerative medicine, offering the potential to treat a wide range of debilitating diseases and injuries. Among the various types of stem cells, mesenchymal stem cells (MSCs) have garnered significant attention due to their unique properties and therapeutic potential. In recent years, researchers have been exploring novel approaches to enhance the effectiveness of MSC-based therapies. One such approach that has gained traction is the priming of MSCs with molecular hydrogen (H2). This article delves into the fascinating world of mesenchymal stem cell priming with molecular hydrogen and the potential benefits it holds for regenerative medicine.

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Immunomodulatory properties of mesenchymal stromal/stem cells: The link with metabolism

Cited by 35 publications

References 196 publications

Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway

Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway

LC-MS/MS-based Quantification of Tryptophan, Kynurenine, and Kynurenic Acid in Human Placental, Fetal Membranes, and Umbilical Cord Samples

Mesenchymal Stem Cell Priming: Potential Benefits of Administration of Molecular Hydrogen

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