Immunomodulatory Role and Therapeutic Potential of Non-Coding RNAs Mediated by Dendritic Cells in Autoimmune and Immune Tolerance-Related Diseases

Liu, Yifeng; Wang, Xiaoze; Yang, Fan; Zheng, Yue; Ye, Tinghong; Yang, Li

doi:10.3389/fimmu.2021.678918

Cited by 7 publications

(8 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, it is worth noting that lncRNAs might participate in the immunopathogenesis of CanL, as they are critical regulators of gene transcription during immune response through regulating protein-protein interactions or via their ability to assemble with RNA and DNA (147)(148)(149)(150). Accordingly, we found that changes in the expression of several lncRNAs were significantly associated with CanL, including an antimicrobial peptide NK-lysin-like (LOC608395) and JUN, which play immunomodulatory roles (151,152).…”

Section: Regulation Of Gene Transcription: Lncrnas and Chromatin Organizationmentioning

confidence: 76%

Modulation of Host Immune Response during Leishmania infantum Natural Infection: A Whole-Transcriptome Analysis of the Popliteal Lymph Nodes in Dogs

et al. 2022

View full text Add to dashboard Cite

Leishmania infantum, the etiological agent of canine leishmaniosis (CanL) in Europe, was responsible of the largest outbreak of human leishmaniosis in Spain. The parasite infects and survives within myeloid lineage cells, causing a potentially fatal disease if left untreated. The only treatment option relies on chemotherapy, although immunotherapy strategies are being considered as novel approaches to prevent progression of the disease. To this aim, a deeper characterization of the molecular mechanisms behind the immunopathogenesis of leishmaniosis is necessary. Thus, we evaluated, for the first time, the host immune response during L. infantum infection through transcriptome sequencing of the popliteal lymph nodes aspirates of dogs with CanL. Differential expression and weighted gene co-expression network analyses were performed, resulting in the identification of 5,461 differentially expressed genes (DEGs) and four key modules in sick dogs, compared to controls. As expected, defense response was the highest enriched biological process in the DEGs, with six genes related to immune response against pathogens (CHI3L1, SLPI, ACOD1, CCL5, MPO, BPI) included among the ten most expressed genes; and two of the key co-expression modules were associated with regulation of immune response, which also positively correlated with clinical stage and blood monocyte concentration. In particular, sick dogs displayed significant changes in the expression of Th1, Th2, Th17 and Tr1 cytokines (e. g. TNF-α, IFN-γ, IL-21, IL-17, IL-15), markers of T cell and NK cell exhaustion (e. g. LAG3, CD244, Blimp-1, JUN), and B cell, monocyte and macrophage disrupted functionality (e. g. CD40LG, MAPK4, IL-1R, NLRP3, BCMA). In addition, we found an overexpression of XBP1 and some other genes involved in endoplasmic reticulum stress and the IRE1 branch of the unfolded protein response, as well as one co-expression module associated with these processes, which could be induced by L. infantum to prevent host cell apoptosis and modulate inflammation-induced lymphangiogenesis at lymph nodes. Moreover, 21 lncRNAs were differentially expressed in sick dogs, and one key co-expression module was associated with chromatin organization, suggesting that epigenetic mechanisms could also contribute to dampening host immune response during natural L. infantum infection in the lymph nodes of dogs suffering from clinical leishmaniosis.

show abstract

Section: Regulation Of Gene Transcription: Lncrnas and Chromatin Organizationmentioning

confidence: 76%

Modulation of Host Immune Response during Leishmania infantum Natural Infection: A Whole-Transcriptome Analysis of the Popliteal Lymph Nodes in Dogs

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The ability to produce cytokines is well known as the symbol of DC function (18,19). Previous studies have shown that hemorrhagic shock induced the dysfunction of cytokine production, such as TNF-α, IL-6, IL-10, IL-12, and so on, in splenic DCs (4,6).…”

Section: Discussionmentioning

confidence: 99%

Posthemorrhagic Shock Mesenteric Lymph Impairs Splenic Dendritic Cell Function in Mice

Liu

Li²,

Zhang³

et al. 2022

Shock

View full text Add to dashboard Cite

Dendritic cell (DC)–mediated immune dysfunction is involved in the process of severe hemorrhagic shock that leads to sepsis. Although post–hemorrhagic shock mesenteric lymph (PHSML) induces immune organs injuries and apoptosis, whether PHSML exerts adverse effects on splenic DCs remains unknown. In this study, we established a hemorrhagic shock model (40 ± 2 mm Hg for 60 min) followed by fluid resuscitation with the shed blood and equal Ringer's solution and drained the PHSML after resuscitation. At 3 h after resuscitation, we harvested the splenic tissue to isolate DCs using anti-CD11c immunomagnetic beads and then detected the necrotic and apoptotic rates in splenocytes and splenic DCs. We also detected the levels of TNF-α, IL-10, and IL-12 in the culture supernatants and surface marker expressions of MHC-II, CD80, and CD86 of splenic DCs following LPS stimulation for 24 h. Second, we purified the DCs from splenocytes of normal mice to investigate the effects of PHSML treatment on cytokine production and surface marker expression following LPS stimulation. The results showed that PHSML drainage attenuated LPS-induced cell death of splenocytes and DCs. Meanwhile, PHSML drainage enhanced the DC percentage in splenocytes and increased the TNF-α and IL-12 production by DCs and the expressions of CD80, CD86, and MHCII of DCs treated by LPS. Furthermore, PHSML treatment reduced the productions of TNF-α, IL-10, and IL-12 and the expressions of CD80 and CD86 in normal DCs after treatment with LPS. In summary, the current investigation demonstrated that PHSML inhibited the cytokine production and surface marker expressions of DCs stimulated by LPS, suggesting that PHSML plays an important role in hemorrhagic shock–induced immunosuppression through the impairment of DC function and maturation.

show abstract

“…DC-mediated non-coding RNA also plays a vital role in autoimmune diseases. 53 In addition to directly affecting autoimmune diseases, DCs exhibit immunosuppressive activity. Immune tolerance can be maintained by regulating DC function.…”

Section: Dendritic Cells and Autoimmune Diseasesmentioning

confidence: 99%

“…The number of DCs in the peripheral blood of patients with autoimmune diseases increases. DC‐mediated non‐coding RNA also plays a vital role in autoimmune diseases 53 …”

Section: Dendritic Cells and Autoimmune Diseasesmentioning

confidence: 99%

Advances in understanding the role of dendritic cells in aplastic anaemia

Gao

Zhang

2023

Scand J Immunol

View full text Add to dashboard Cite

Aplastic anaemia (AA) is an autoimmune disease characterized by haematopoietic failure in the bone marrow. Abnormal activation and hyperfunction of T lymphocytes are believed to cause bone marrow damage, which plays a major role in AA pathogenesis. Dendritic cells (DCs) play a vital role in the immune system by processing antigens for presentation to T cells and regulating their differentiation and function. DC dysfunction may cause abnormal T‐cell activation. Recent studies have associated the occurrence and development of AA with DC function. In this review, we have discussed the role of DCs in AA pathogenesis and their potential as putative therapeutic targets for AA.

show abstract

Immunomodulatory Role and Therapeutic Potential of Non-Coding RNAs Mediated by Dendritic Cells in Autoimmune and Immune Tolerance-Related Diseases

Cited by 7 publications

References 121 publications

Modulation of Host Immune Response during Leishmania infantum Natural Infection: A Whole-Transcriptome Analysis of the Popliteal Lymph Nodes in Dogs

Modulation of Host Immune Response during Leishmania infantum Natural Infection: A Whole-Transcriptome Analysis of the Popliteal Lymph Nodes in Dogs

Posthemorrhagic Shock Mesenteric Lymph Impairs Splenic Dendritic Cell Function in Mice

Advances in understanding the role of dendritic cells in aplastic anaemia

Contact Info

Product

Resources

About