Immunomodulatory role of edible bone collagen peptides on macrophage and lymphocyte cell cultures

Soriano-Romaní, Laura; Nieto, Juan Antonio; García-Benlloch, Sandra

doi:10.1080/09540105.2022.2098936

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…In fact, one of the main limitations of in vitro studies is the lack of information concerning stability of peptides during gastrointestinal digestion, absorption in the lumen, and their reaching to the target organ and actual bioactivity exerted. Usually, in situ cell-based and/or ex vivo analysis may narrow the gap between the in vitro assays and the in vivo studies, but still these cannot be considered as highly relevant evidence [ 14 ]. Several authors have aimed to define the molecular features making a peptide bioactive towards specific targets [ 15 , 16 ], but considering the high amount of sites where peptides can bind the target enzymes on which they exert the activity, a single sequence could potentially exert diverse bioactivities [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Evidence of Immunomodulatory Food-Protein Derived Peptides in Human Nutritional Interventions: Review on the Outcomes and Potential Limitations

et al. 2023

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The immune system is somehow related to all the metabolic pathways, in a bidirectional way, and the nutritional interventions affecting these pathways might have a relevant impact on the inflammatory status of the individuals. Food-derived peptides have been demonstrated to exert several bioactivities by in vitro or animal studies. Their potential to be used as functional food is promising, considering the simplicity of their production and the high value of the products obtained. However, the number of human studies performed until now to demonstrate effects in vivo is still scarce. Several factors must be taken into consideration to carry out a high-quality human study to demonstrate immunomodulatory-promoting properties of a test item. This review aims to summarize the recent human studies published in which the purpose was to demonstrate bioactivity of protein hydrolysates, highlighting the main results and the limitations that can restrict the relevance of the studies. Results collected are promising, although in some studies, physiological changes could not be observed. When responses were observed, they sometimes did not refer to relevant parameters and the immunomodulatory properties could not be clearly established with the current evidence. Well-designed clinical trials are needed in order to evaluate the role of protein hydrolysates in immunonutrition.

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