Immunonutrients and intestinal microbiota: a gap in the literature

Abreu Nascimento, Manuela de; Matta Alvarez Pimenta, Nina da; Aiceles de Medeiros Pinto Polastri, Veronica; Cardoso Chamon, Raiane; Sarto Figueiredo, Mariana

doi:10.1080/10408398.2023.2260468

Cited by 1 publication

(2 citation statements)

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“…In the particular case of the study presented herein, it should be emphasized that the tested intervention contains dietary nucleotides and O3s. Both nucleotides and O3s are immunonutrients that interact with and modulate the gut microbiota composition and variability [ 27 ]. This may have an impact on the systemic inflammatory response and eventually result in clinical benefits for patients suffering from skin conditions.…”

Section: Discussionmentioning

confidence: 99%

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Yeast-Derived Nucleotides Enhance Fibroblast Migration and Proliferation and Provide Clinical Benefits in Atopic Dermatitis

Segarra,

Bošnjak,

Mioč

et al. 2024

IJMS

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Nucleotides, glycosaminoglycans, and omega-3 essential fatty acids (O3s) could be used for improving skin health, although their modes of action, alone or in combination, are not yet fully understood. To gain some insight into these mechanisms, we performed two in vitro tests and one in vivo pilot trial. The effects on human dermal fibroblast proliferation and migration were evaluated with the following compounds and combinations: 0.156 mg/mL O3s, 0.0017 mg/mL hyaluronic acid (HA), 0.0004 mg/mL dermatan sulfate (DS), 0.0818 mg/mL nucleotides, and [O3s + HA + DS] and [O3s + HA + DS + nucleotides] at the same concentrations. In both in vitro assays, adding nucleotides to [O3s + HA + DS] provided significant improvements. The resulting combination [O3s + HA + DS + nucleotides] was then tested in vivo in dogs with atopic dermatitis by oral administration of a supplement providing a daily amount of 40 mg/kg nucleotides, 0.9 mg/kg HA, 0.18 mg/kg DS, 53.4 mg/kg EPA, and 7.6 mg/kg DHA. After 30 days, the pruritus visual analog scale (pVAS) score was significantly reduced, and no adverse effects were observed. In conclusion, the combination of nucleotides plus glycosaminoglycans and O3s could serve as a useful therapeutic alternative in skin health applications.

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Section: Discussionmentioning

confidence: 99%

“…Both nucleotides and O3s are considered immunonutrients. The potential to modulate the activity of the immune system by using specific nutrients is termed immunonutrition, an approach closely associated with possible clinical improvements [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%