Immunonutrition as a component of immunomodulating program in the elderly patients in non-Covid-19 hospital

Arykan, N.G.; Шестопалов, А. Е.; Evdokimov, E. A.; Varnavin, O.; Vasin, V.; Charchan, A.; Neudakhina, O.

doi:10.1016/j.clnesp.2020.09.582

Clinical Nutrition ESPEN

2020

DOI: 10.1016/j.clnesp.2020.09.582

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Immunonutrition as a component of immunomodulating program in the elderly patients in non-Covid-19 hospital

N.G. Arykan

А. Е. Шестопалов

E. A. Evdokimov

et al.

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2024

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Immunonutrition in Acute Geriatric Care: Clinical Outcomes, Inflammatory Profiles, and Immune Responses

Boccardi,

Cari,

Naghavi Alhosseini

et al. 2024

Nutrients

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Background and Aims: Malnutrition is common in acutely ill geriatric patients, worsening immune function and clinical outcomes. Immunonutrition, containing nutrients like omega-3 fatty acids, arginin and glutamine, may improve recovery in this population. This study aimed to evaluate the impact of immunonutrition on clinical outcomes, inflammatory markers, and immune responses in frail, hospitalized older adults. Methods: This is a retrospective observational study. In total, 36 subjects, during hospitalization, received either an immunonutrition formula or isoproteic and isocaloric enteral nutrition. The primary outcome was the length of hospital stay (LOS), with secondary outcomes focused on inflammatory cytokines and immune parameters within a week of hospitalization. Results: Patients were primarily oldest-old, with a mean age of 88.6 years ± 4.9 (range 79–96). The immunonutrition group had a significantly shorter LOS (11.37 ± 4.87 vs. 16.82 ± 10.83 days, p = 0.05) and showed increases in key cytokines (G-CSF, INF-α2, IL-12p70, IL-15, IL-2, and IL-3, p < 0.05) enhanced immune function. A decrease in T cells and an increased B/T cell ratio was also observed. No significant differences in infection rates or 90-day survival were found. Conclusions: Enteral immunonutrition improved clinical outcomes by reducing LOS and modulating immune responses in frail patients, suggesting potential benefits in recovery. Further studies are needed to confirm these findings.

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Immunonutrition in Acute Geriatric Care: Clinical Outcomes, Inflammatory Profiles, and Immune Responses

Boccardi,

Cari,

Naghavi Alhosseini

et al. 2024

Nutrients

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Immunonutrition as a component of immunomodulating program in the elderly patients in non-Covid-19 hospital

Cited by 1 publication

References 0 publications

Immunonutrition in Acute Geriatric Care: Clinical Outcomes, Inflammatory Profiles, and Immune Responses

Immunonutrition in Acute Geriatric Care: Clinical Outcomes, Inflammatory Profiles, and Immune Responses

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