Immunopathogenesis of oral submucous fibrosis by chewing the areca nut

Wang, Liping; Tang, Zhangui

doi:10.1002/jlb.3mr0521-763rr

Cited by 21 publications

(15 citation statements)

References 69 publications

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“…While oxidative stress is indeed associated with OSMF, tissue inflammation is crucial for the induction of tissue fibrosis. The involvement of prostanoids and other inflammatory mediators [90,91] as well as immune cells (recently reviewed in [92]) is central to OSMF pathogenesis but was not in the scope of our review.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

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Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. To assess the scope for mechanism-based approaches to prevent or reverse OSMF, we systematically evaluated the existing literature and investigated the role of oxidative stress in the pathogenesis and chemoprevention of OSMF. A search for relevant articles on PubMed and Scopus was undertaken using pre-defined inclusion and exclusion criteria. A total of 78 articles were selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The articles eligible for assessment investigated both OSMF and/or oxidative stress biomarkers or specific antioxidants. Both in vitro and human studies consistently demonstrated variations in oxidative stress biomarker levels in OSMF and revealed an increase in oxidative stress, paralleling the development of the disease. Furthermore, the use of antioxidant supplements was overall associated with an improvement in clinical outcomes. Having identified the significance of oxidative stress in OSMF and the therapeutic potential of antioxidant supplements, this scoping review highlights the need for further well-designed studies in the development of mechanism-based interventions for managing OSMF.

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Section: Strengths and Limitationsmentioning

confidence: 99%

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

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“…20 Chewing betel nut can induce oral cancer through various mechanisms, such as promoting the fibrosis of oral epithelial cells, enhancing the drug resistance of cancer cells, and changing the oral microecology. [21][22][23] However, the effects of betel nut on human health may be two-sided. Studies have shown that betel nut can resist migraines, reduce cholesterol levels, and regulate glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

UPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut

Yang¹,

Huang²,

Cui³

et al. 2021

DDDT

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Background: Betel nuts have long been used in traditional Chinese medicine. In our study, the bioactive components of betel nut were systematically investigated, and the main components and their target genes in the treatment of depression were predicted. Methods: The metabolites of the kernels and peels were analyzed with a UPLC-MS/MS system. Mass spectrometry outcomes were annotated by MULTIAQUANT. "Compounddisease targets" were utilized to construct a pharmacology network. Results: A total of 873 metabolites were identified, with a high abundance of flavonoids, alkaloids, and phenols. Moreover, the abundance of flavonoids, alkaloids, and phenols in the kernel was significantly higher than that in the peel. A high abundance of catechin, arginine, and phenylalanine was detected in the kernel, while a high abundance of arginine, arecoline, and aminobutyric acid was detected in the peel. Catechins and cyanoside were the most abundant flavonoids in the kernel and peel, respectively. Arecoline was the most abundant alkaloid. A total of 111 metabolites showed a significant difference between the kernels and peels. The relative abundance of 40 differential metabolites was higher than 100,000, including 14 primary metabolites, 12 flavonoids, 4 phenols, and 4 alkaloids. Among the 40 high abundance metabolites, 20 were higher in the kernel and 20 in the peel. In addition, the enrichment of metabolic pathways found that the kernel and peel of the fruit adopted different metabolic pathways for the synthesis of flavonoids and alkaloids. Network pharmacology prediction showed that 93 metabolites could target 141 depression-related genes. The main components of betel nut intervention in depression were predicted to include L-phenylalanine, protocatechuic acid, okanin, nicotinic acid, L-tyrosine, benzocaine, syringic acid, benzocaine, phloretic acid, cynaroside, and 3,4-dihydroxybenzaldehyde. Conclusion: Betel nuts are rich in natural metabolites, and some of these metabolites can participate in the intervention of depression. In addition, the metabolites showed distinct characteristics between the kernel and peel. Therefore, it is necessary to comprehensively and rationally use betel nuts.

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“…In most cases, oral cancer develops 3-16 years following the initial diagnosis of OSF. 4 unfortunately, there are no clinically viable treatments for OSF.…”

Section: Introductionmentioning

confidence: 99%

Oral submucous fibrosis: A review on current treatment approaches

S¹,

V²,

Sowmya³

2023

World J. Bio. Pharm. Health Sci.

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Oral submucous fibrosis (OSF) is caused by aberrant collagen deposition in the oral mucosa. A chronic, creeping, scarring disease of the oral cavity often involving the pharynx and upper oesophagus is how it's been described for centuries. It is the most dangerous oral premalignant condition and evolve into malignant tumours in 1.5% to 15% of cases. It is found primarily in India, Pakistan, Sri Lanka, and Bangladesh. Submucous fibrosis, ulceration, xerostomia, a burning feeling, and a restricted opening of the mouth are some of the signs and symptoms to look out for. A patient's quality of life is severely affected by all of these factors. Chewing on areca nuts is the most significant source of danger. Efforts to improve management have been ongoing due to the disease's high mortality and high malignant transformation rate, respectively. Understanding the precise involvement of etiological agents in pathogenesis will aid in management and therapy methods. From a molecular standpoint, this paper provides an overview of background of OSF, including its underlying processes, diagnostic biomarkers, and therapy options. Prevention of OSF is just as crucial as rigorous therapy. For future studies to be effective, oral health literacy has to be improved among people at risk for OSF.

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Immunopathogenesis of oral submucous fibrosis by chewing the areca nut

Cited by 21 publications

References 69 publications

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

UPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut

Oral submucous fibrosis: A review on current treatment approaches

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